Friday, September 26, 2014 12:19:37 PM
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JCI Impact (Journal of Clinical Investigation)
pg# 5 of 20
June 2014
ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis
Thomas Condamine1, Vinit Kumar1, Indu R. Ramachandran1, Je-In Youn1, Esteban Celis2, Niklas Finnberg3, Wafik S. El-Deiry3, Rafael Winograd4, Robert H. Vonderheide4, Nickolas R. English5, Stella C. Knight5, Hideo Yagita6, Judith C. McCaffrey2, Scott Antonia2, Neil Hockstein7, Robert Witt7, Gregory Masters7, Thomas Bauer7 and Dmitry I. Gabrilovich1
1 The Wistar Institute, Philadelphia, Pennsylvania, USA.
2 H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
3 Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA.
4 Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
5 Antigen Presentation Research Group, Imperial College London, London, United Kingdom.
6 Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
7 Helen F. Graham Cancer Center and Research Institute, Christiana Care Health System, Newark, Delaware, USA.
Address correspondence to: Dmitry I. Gabrilovich, The Wistar Institute, 3601 Spruce Street, Room 118, Philadelphia, Pennsylvania 19104, USA. Phone: 215.495.6955; Fax: 215.495.6948; E-mail: dgabrilovich@wistar.org.
First published May 1, 2014
http://jci.me/74056
http://static.jci.org/impact/2014/jci_impact_2014_06.pdf
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I have already included the link above under my string of posts re: Dmitry Gabrilovich, and want to add it to Peregrine KOL: Scott Antonia, as we must not forget all the KOL's are here for a specific reason, to further educate the medical community about immuno-oncology and how to best optimize ones immune system, because since they are with Peregrine... and Peregrine is all about optimizing ones immune system via PS Targeting, with drugs that target flipped-PS such as Bavituximab.... I do hope they start to bridge the gap and connecting the dots that many here since all 4 KOL's decided to back Peregrine on Dec 10, 2013.
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Prelude To A Cure For Cancer: The Grand Finale To Lung Cancer
Dr. Lary Robinson: President
Lary Robinson, MD, is one of the nation's most highly recommended thoracic surgeons. Upon completion of his medical degree from Washington University School of Medicine in St. Louis, Missouri, Dr. Robinson continued his education with general and thoracic surgery residencies at Duke University as well as a fellowship in cardiac research and clinical cardiac surgery at St. Thomas' Hospital in London, England. He is currently practicing thoracic Surgical Oncology at Moffitt Cancer Center. He is author of over 120 medical publications, 19 book chapters, and editor of a textbook, most of which involve thoracic oncology. Throughout his years as a medical professional, Dr. Robinson has been directly involved in 8 clinical cancer research programs relating to lung cancer and mesothelioma. Throughout his carer, thousands of patients have been treated successfully with Dr. Robinson's clinical expertise and compassionate
Dr. Scott Antonia: Vice President
Scott Antonia, MD, PhD is a Professor of Oncology holding the positions of Co-Leader of the Immunology Program and Chairman of the Thoracic Oncology Department at Moffitt Cancer Center. A Medical Oncologist in the Thoracic Department specializing in lung cancers, Dr. Antonia received basic research training in cellular immunology while participating in a physician scientist training program at the University of Connecticut (1983-1987). Upon completion of medical school and internal medicine training at Yale, he trained with Dr. Richard Flavell (Immunobiology, Yale School of Medicine) during his Medical Oncology fellowship, receiving further research experience in cellular immunology as well as molecular biology (1992-1994). At Moffitt Cancer Center, Dr. Antonia has developed a translational research program utilizing his molecular biology and cellular immunology training in the development of immunotherapeutic strategies for the treatment of cancer patients.
http://www.preludetoacure.com/
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BY LAURA CONE
The Brandon News
Published: September 24, 2014
BRANDON — The loss of a close friend fuels Kathy Greene’s fight against a faceless foe.
Greene is helping to organize the Prelude to a Cure event, “The Ribbon is White — Bring it to Light,” claiming that many people are still in the dark about lung cancer. She lost her good friend, nonsmoker Barbara Bauer, to lung cancer in November 2012.
This year’s Prelude to a Cure fundraiser will take place Nov. 7 from 6 to 10 p.m. at Center Place Fine Arts & Civic Association, 619 Vonderburg Drive, Brandon. November is also Lung Cancer Awareness month.
“We were astounded to learn that so many of us had no idea that lung cancer is the leading cancer killer in the U.S.,” Greene said. “The primary misconception is that people who get lung cancer are always smokers. People, and increasingly, women, who never smoked are being diagnosed with lung cancer daily.”
She said the theme of this year’s event was the result of Dr. Lary Robinson’s presentation last year at the White Ribbon Soiree about searching for answers in the dark. Robinson, a thoracic surgeon and co-founder of Prelude to a Cure, will be the keynote speaker again this year. Robinson founded Prelude to a Cure with Dr. Scott Antonia, a nationally renowned thoracic researcher.
“We have designed this year’s event to be a more intimate evening with approximately 80 guests expected,” she said. “Many of these people have stepped up to help sponsor the new Prelude to a Cure website. The goal of the website is to increase awareness, provide answers for patients and families facing a lung cancer diagnosis, and to raise much-needed funding for lung cancer research.”
Greene said she is excited about the Young Investigator Research grant, which is being established to encourage student scientists to explore uncharted possibilities for the causes and treatment of lung cancer.
“The data provided by these grants will enable the Moffitt team to apply for larger federal grants to continue searching for a cure,” she said. “This grant was established in honor of Barbara Bauer because the initial funding was generated from the White Ribbon Soiree event last year held in her memory. Barb Bauer and other people affected by and lost to lung cancer are still the inspiration behind finding a cure.”
Greene, and other volunteers for the fundraising event, worked out with Bauer at the Core Fitness Studio in Valrico. Bauer was diagnosed with small cell lung cancer in July of 2011.
The event will include musical entertainment, a live auction and food prepared by Chef Dave West of the Rolling Pin.
There are three levels of sponsorship, ranging from $1,000 to $5,000. To learn more, contact Debbie Ploor at Orange Home Decor and Accessories, (813) 681-8686. People who make a $10 donation can receive the “Just Breathe” bracelet that is available on the website at prelude toacure.com.
http://tbo.com/brandon/prelude-to-a-cure-searches-for-answers-to-lung-cancer-20140924/
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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