Innovation Pharmaceuticals Inc (IPIX)

[Whoops]

I don't think one SAE in a trial with 200 patients is of much concern. If its even a SAE and not Dapto. I have been on a lot of prescription drugs that came with warnings, liver failure seems to be a popular one my personal favorites is death and they suggest you contact your doctor if it occurs etc.

My general feel for the poly assets is that the drugs were wonderfully powerful and PolyM tended OD (over dose) them in their limited human trials. Having said that if it is a SAE related to Brilacidin I would guess it came in the 3 day arm of the study where the OD scenario may have played out again. It looks like all 3 arms of B were successful and I was cheering for one of the one day doses anyways. The 3 day dose total would be 1.2 mg/kg total and the low single 0.6 mg/kg so we have a half dose from the high to work with. It would be interesting to see a plasma drug levels peak and trough against time for B for residual effects.

I am not ruling out that a SAE occurred in the Dapto arm. There is a known hypersensitivity/allergic reaction to Daptomycin with its own SAE's.