Avid Bioservices Inc (CDMO)

[biopharm]

Dmitry Gabrilovich : Peregrine Pharmaceuticals KOL : ... hot from the press and wonder if Alison Stopek picks up on these findings....

As we have all seen the progression of Dmitry Gabrilovich and his understanding, expert understanding I should say.. of MDSC's, I wonder how much longer we must wait to confirm the results.

Can the Suppressive Activity of Myeloid-Derived Suppressor Cells Be “Chop”ped?

Thomas Condamine1,
Dmitry I. Gabrilovich1, ,

1 The Wistar Institute, Philadelphia, PA 19104, USA

Available online 18 September 2014

http://www.sciencedirect.com/science/article/pii/S1074761314003100

So Dmitry and Thomas still at it.... and I believe they have seen the wonders of Bavituximab and PS Targeting, vs their "unclear" findings back in 2012. As there was much going on back in Dec 2012, Dmitry was just miles away talking up MDSC's and I can bet you Dmitry has a much clearer understanding at this time... all due to seeing PS Targeting first hand.

Accumulation of Myeloid-Derived Suppressor Cells in Bone Marrow in Multiple Myeloma Induces Tumor-Specific Immune Suppression and Promotes Tumor Growth

Dec 2012

Indu R Ramachandran, PhD*, Anna Martner, PhD*, Thomas C Condamine, PhD*, Alexandra Pisklakova, MD*, Tess Chase*, Dmitry Gabrilovich, MD, PhD* and Yulia Nefedova, MD, PhD

H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL


Multiple myeloma (MM) is an incurable malignancy of clonal plasma cells in bone marrow (BM). Accumulation of MM cells in BM is associated with a corresponding dysfunction of local immune responses. The mechanisms involved in the immune suppression remains poorly understood. Myeloid-derived suppressor cells (MDSC) are heterogeneous group of relatively immature myeloid cells characterized by potent immune suppressive activity. However, their role in regulation of immune responses in BM in MM remains unclear.

To determine MDSC accumulation in MM patients, BM and blood samples were obtained from newly diagnosed patients and healthy donors. We observed a significant increase in CD11b+ CD33+ CD14- HLA-DRlo MDSCs, but not in CD11b+ CD33+ CD14+ HLA-DRhi monocytes, in the blood and BM of patients as compared to cells with the same phenotype in healthy donors. MDSC isolated from patient BM suppressed T cell responses as measured by IFN-g Elispot assays of mixed leukocyte reactions. Immature myeloid cells with the same phenotype from BM of healthy donor did not inhibit T cells.

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https://ash.confex.com/ash/2012/webprogram/Paper55167.html

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their role in regulation of immune responses in BM in MM remains unclear ... now I think we can say Dmitry knows their role in regulation of immune responses and lets talk more about BM = bone marrow.

The basics:
http://www.sciencedaily.com/articles/b/bone_marrow.htm

Osteoporosis has more flipped PS than you think, and you're only as strong as your bones:
http://health.msn.co.nz/healthnews/8909843/revolutionary-stem-cell-paste-could-help-repair-bones

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... just like cancer and various chemo treatments, competition is heating up, Big Pharma buyouts, M/A's and eveyone positioning themselves for a big, bright future.

PS Targeting is required for it all, and did I mention Bavi crops as well...? : )