Avid Bioservices Inc (CDMO)

[Protector]

biopharm, I think surgery in general, including all kinds of transplants, would benefit from Bavituximab under the current version of the MOA.

Pre- and post operative application. In the end, if we simplify it to its essence, what is surgery from an immune system's perspective?

It is DAMAGING of cells physically/mechanically (cutting), massively where the cuts are (so localized). Cell damage=release/exposure of PS. Phosphatidylserine (PS) suppresses the dendric cells and macrophages signalling for immune system activation support. That is no different as when the PS gets exposed due to chemo, radio or immuno therapies or by natural or programmed cell death or by any viral attack.

Hence healing is slow and infections (because the dendric cells are affected too) can flourish.

And what are the biggest problems with surgery once the patient is awake again? Right, the risk for infections.

So pre- and post treat patients with Bavituximab, daily (which with important operations isn't an issue because you'll remain in the hospital anyway), with an adequately researched dosage.