NanoViricides Inc. (NNVC)

[Ubertino]

NPC1 binding - Bigger pic:

Figure 3. Infectious entry of filoviruses into target cells. After interaction between GP1,2 and cellular surface molecules, virions are internalized via macropinocytosis into the endosomal compartment. Subsequently, the endosomal cysteine proteases cathepsin B and L proteolytically process GP1,2 , thereby removing the glycan cap (indicated by grey caps) and allowing primed GP1 binding to Niemann-Pick C1 (NPC1), which is essential for the following virus-host membrane fusion process. Finally, a so far incompletely understood stimulus triggers the membrane fusion activity in GP2.


I take it the NPC1 are those blue structures. It shows the virus in its own endosomal pocket about to enter the cell proper after the NPC1 attaches and its tail pierces the cell wall. I take it that EbolaCide2 has those blue structures as ligands on the polymer micelle to attract the Ebola virus and trap it.

http://www.mdpi.com/1999-4915/4/12/3336/htm