Avid Bioservices Inc (CDMO)

[nuke661]

Wook,

I saw this video yesterday while surfing and before my wife put me to work. I saw the Nivolumab label and discounted it being Bavi. I just assumed there are more cell surface targets other than just PS that can have a basic MOA description similar to Bavi. If it is PS they are targeting then they certainly weren't broadcasting it. Notice they weren't specific in the video regarding the target.

I thought it might be PS targeting experiments by a BP to check PS out themselves using patent loopholes for research. This is just a wild ass possibility line of thinking I had because the MOA for Nivolumab doesn't sound anything like what was described in the video and there is nothing directly connecting the label on the IV bag directly to the drug being discussed. They never said what the drug was and only provided the MOA cartoon.


Nivolumag MOA Info
Source

MECHANISM OF ACTION OF NIVOLUMAB In vitro, nivolumab binds to PD-1 on activated human T cells with high affinity (half maximal effective concentration [EC50]: 0.64 nM by FACS analysis and 2.6 nM by Scatchard), and inhibits the binding of PD-1 to its ligands, programmed death-ligand-1 (PD-L1) and programmed death-ligand-2 (PD-L2) (half maximal inhibitory concentration [IC50] of ~1 nM).1 Nivolumab binds specifically to PD-1 and not to related members of the CD28 family such as CD28, inducible co-stimulator (ICOS), cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and B and T lymphocyte attenuator (BTLA). Blockade of the PD-1 pathway by nivolumab results in a reproducible enhancement of both proliferation and IFN- release in the models