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Friday, 08/22/2014 10:40:29 AM

Friday, August 22, 2014 10:40:29 AM

Post# of 144814
This article references (7) the Lohr, Salmons, Gunzburg paper/work of 1998. We already know about the success of those initial tests. It goes on to talk about a similar test using "engineered breast cancer cells were mixed with nonexpressing cells, and the resultant mixtures were injected into nude mice". interesting wording...."Expression of the drug-activating enzyme was able to convert the prodrug into the cytotoxic moiety in vivo, resulting in either cures or tumor regression in all surface-tethered CPG2(Q)-3-expressing groups (61) ." Heard "regression" before but not "cure". Very interesting, hopefully this is along the lines of what Von Hoff is thinking too.

http://clincancerres.aacrjournals.org/content/7/11/3314.long
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