Calmare Therapeutics Inc (fka CTTC)

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Calmare Clinical Trials

There are several studies that have been performed to evaluate the efficacy of the treatment including a pilot study at The Massey Cancer Center where 16 patients with CIPN (chemotherapy-induced peripheral neuropathy) were treated, and 64% was the overall score reduction in pain. Fifteen of the 16 patients had a significant reduction in their pain score. These results were published in the Journal of Pain and Symptom Management.

Dr. Thomas Smith, director of Palliative Care at Johns Hopkins, recently did a pilot study for PHN patients where they achieved an amazing 95% reduction in pain a month after the treatment with no side effects. Another study recently published in the Journal of Pain and Symptom Management with 52 random pain participants compared guideline-based drug management with Scrambler and the results were amazing. The Calmare® participants had a 91% reduction in pain compared to a 28% reduction in pain for those who used drug management.

The Mayo Clinic is currently conducting three studies; one will be completed the first half of 2013. And The University of Wisconsin has just completed a double-blind study with a sham device. Those results will be published in the near future. The Massey Cancer Center just completed a phase II study with 39 patients that will be published in the near future. They achieved a 3.3 reduction in pain on a 0 to 5 scale.

Recently it was announced that the U.S. military has purchased 15 Scrambler Therapy units for several U.S. military medical facilities in the U.S. and overseas including The VA, The U.S. Army, The U.S. Air Force, and The U.S. Navy. Currently The Mayo Clinic, The Massey Cancer Center, and The University of Wisconsin are conducting studies using the Calmare® device.

Clinical Trials


•Trial of Scrambler Therapy or Sham Treatment for Low Back Pain NCT ID: NCT01896687
Sponsor: Virginia Commonwealth University, School of Nursing
Principal Investigator: Angela Starkweather
Protocol IDs: SCRA-LBP
•Scrambler Therapy in Treating Chronic Pain in Patients With Rash From Varicella Zoster Virus Infection NCT ID: NCT01347736
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10CE, NCI-2011-00338
•Scrambler Therapy in Treating Pain and Peripheral Neuropathy in Patients Previously Treated With Chemotherapy NCT ID: NCT01347723
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10CC, NCI-2011-00339
•MC5-A Scrambler Therapy in Reducing Peripheral Neuropathy Caused by Chemotherapy NCT ID: NCT01290224
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10C8, NCI-2011-00109, 10-007874
•MC-5A for Chemotherapy Induced Peripheral Neuropathy NCT ID: NCT01261780
Sponsor: University of Wisconsin, Madison
Principal Investigator: Toby Campbell
Protocol IDs: OS10328
•Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer NCT ID: NCT01196442
Sponsor: Virginia Commonwealth University, Massey Cancer Center
Principal Investigator: Thomas J. Smith
Protocol IDs: MCC-13098, NCI-2010-01945

Calmare Case Studies

Artificial Neurons in Oncological Pain –G. Marineoa, S. Spazianib, A.F. Sabatoc, F. Marottaa

Untreatable Pain Resulting from Abdominal Cancer:New Hope from Biophysics?–Giuseppe Marineo

Scrambler Therapy–A.F. Sabato, G. Marineo, A. Gatti

Safety and Efficacy of Scrambler Therapy for Cancer Pain–M. Ricci, S. Pirotti, M. Burgio, E. Scarpi, E. Sansoni, R. Ridolfi, D. Amadori, M. Maltoni

Pilot Trial of a Patient-Specific Cutaneous Electrostimulation Device (MC5-A Calmare
) for Chemotherapy-Induced Peripheral Neuropathy–T. J. Smith, MD, P. J. Coyne, RN, MSN, G. L. Parker, RN, MSN, P. Dodson, BSN, MA, and V. Ramakrishnan, PhD

The Use of “Scrambler Therapy” for Failed Back Surgery Syndrome–S. Abdi, MD, PhD, V M Lakkimsetty MD, J. Barrera, MD, K. Candiotti, MD, D. Lubarsky, MD

Managing Chronic Pain: Results From An Open-label Study using MC5-A Calmare® Device–M. Ricci, S. Pirotti, E. Scarpi, M. Burgio, M. Maltoni, E. Sansoni, D. Amadori

Pilot Study of Scrambler Therapy for the Treatment of Chemotherapy-induced Peripheral Neuropathy–D. R. Pachman, B. M. Linquist, D. L. Barton, K. C. Fee-Schroeder, T. J. Smith, D. H. Lachance, H. Liu, D. K. Seisler, C. L. Loprinzi

Treatment of Post-herpetic Pain with Scrambler Therapy, a Patient-specific Neuro-cutaneous Electrical Stimulation Device–T. J. Smith, G. Marineo

Scrambler Therapy for Patients with Cancer Pain–Park HS, MD, Sin WK, MD, Kim HY, MD, Moon JY, MD, Park SY, MD, Kim YC, MD, Lee SC, MD

Scrambler Therapy: An Innovative and Effective Treatment for Chronic Neuropathic Pain–F. Sparadeo, Ph.D., C. Kaufman, RN, BScN, CLCp, CNLCP, S. D ‘Amato, M.D.

Scrambler Therapy May Relieve Chronic Neuropathic Pain More Effectively Than Guideline-Based Drug Management: Results of a Pilot, Randomized, Controlled Trial–G. Marineo, PhD, V. Iorno, MD, C. Gandini, MD, V. Moschini, MD, T. J. Smith, MD

Clinical Experiences on the Effect of Scrambler Therapy for Patients with Postherpetic Neuralgia–Ko YK, MD, Lee HY, MD, Lee WY, MD

Link with easy click through links: http://www.calmarerelief.com/clinical-trials/