Innovation Pharmaceuticals Inc (IPIX)

[RJFL]

To further cloud things, if you use Table one in the Sharma.... study you calculate HED by dividing the animal dose, in this case the mouse dose of 200 mg/kg, by 12.3, thus a result of 16.2 mg/kg is HED, conversely you can determine the HED by also multiplying by 0.081 which also yields 16.2 mg/kg. The conversions are based on using the exponent of 0.67 for body surface area in humans. I like the table 1 conversions better!