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Saturday, 08/09/2014 1:28:13 PM

Saturday, August 09, 2014 1:28:13 PM

Post# of 403097
Leo's old email about calculating the body surface area:

Body surface area is calculated by the formula:

http://upload.wikimedia.org/math/5/4/7/5474a2b51cbed825b9f5de8e9a058178.png

Average men may be about 1.73 m^2 and women 1.71 m^2, or they receive about 17.3mg OR 17.1 mg respectively. It is calculated individually before administration.

We have no way of being certain but expect MTD could be reached in 5 to 9 cohorts. (If this werent a cancer study with stage 4 patients, one would estimate about 5 cohorts to reach MTD.)


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