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Re: CallMeCrazy post# 64254

Saturday, 08/02/2014 4:26:02 PM

Saturday, August 02, 2014 4:26:02 PM

Post# of 403091
Great post CallMeCrazy. What sets Cellceutix apart is the multiple drugs/platforms they are developing, they are not a one trick pony. This reduces investment risk but it will take time to come to full fruition. "K and B" are both unique in their approach. To date nobody has introduced a drug (without undue toxicity) to fully restore P53. Similarly "B" offers a unique approach by cell wall destruction or defensin mimetics.

I think most are here for "K" as it offers incredible opportunities for use considering wild/mutant P53 is implicated in so many cancer types. It's exciting to see we have not had serious safety setbacks thus far and are now in the range where true therapeutic utility is anticipated. Couple that with the suggestive benefit to a small sample set of patients at low doses (restaging of patients) definitely gets us excited since the results were with advanced 4th stage patients. Intuitively repair of P53 might best be achieved by use of the drug earlier in the disease process (stage 1/2) so there is less of a tumor burden and before the patients immune systems are not as compromised as those who have gone thru several types or rounds of debilitating chemotherapy. I think this might ultimately be the best use for "K" however that question will require further "targeted" trials down the road. Consider that tamoxifen, a prophylactic use drug during it's heyday was about a 600 million per year advocated for just specific types of breast cancer patients. P53 is implicated in multiple (50%?) types of cancers, thus the potential applications are staggering. The fact that Cellceutix also has "B" and "P" in the pipeline is what sets Cellceutix apart. Those that are patient will be rewarded in my opinion, it will take multiple years to fully see the potential but the potential is so mind boggling assigning a future value is almost impossible. Saturday afternoon ramblings......
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