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Re: NewMoney post# 95752

Thursday, 07/31/2014 12:51:33 PM

Thursday, July 31, 2014 12:51:33 PM

Post# of 146240
Some unknown Ebola drug was sent, only enough for one person:

http://www.nbcnews.com/storyline/ebola-virus-outbreak/only-enough-one-experimental-ebola-serum-used-u-s-patient-n169626

Nice Forbes article about current Ebola drugs in development

www.forbes.com/sites/davidkroll/2014/07/29/ebola-outbreak-fears-will-any-drugs-work

NNVC also "actually has an experimental Ebola drug," which the US Army tested, but it is not currently in active development, AFAIK, due to other priorities.

The issue of whether or not to test a drug can be summed up:

“Our challenge right now is that, in the absence of human safety data, we don’t see a path to dose patients without at least some fundamental safety data. There would be some ethical issues around that, so it’s a catch-22,” Bennett added.

You need at least some Phase I data showing safety to let people trying the drug to know what to expect, i.e. to be able to give informed consent to try an investigational drug.

On the other hand, given a known 60-90% chance of death with no treatment, the benefit of a chance that a drug might help likely outweighs the risk of (1) the drug making you sick / killing you or (2) the virus killing you anyways.

So, as has been stated before, Phase I safety data really should be in hand to gauge risks before trying any new drug. NNVC doesn't have any human safety data, and they won't until they determine safety data in animals, which requires much more material than needed for treatment, since the material (Cides) are so non-toxic, and NNVC is constrained in producing enough material at its existing facility to start that testing.

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