Indeed, what oncologist would not opt to avoid mutations? It is the key.
I can't find a prior post from someone who has noted that AEs related to blood clots have dropped to zero since Ariad started better screening. If that is the case, pona should certainly be a front line candidate. You can see why Denner loves Iclusig. Add in off-label stuff, other applications etc.and we might have a real drug here.
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