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Thursday, July 24, 2014 2:15:24 PM
"However, relatively few genes were repeatedly found to be differentially expressed in the course of time. This indicated that the gene regulatory effects of GA on monocytes are rather modest and no stable gene expression signature could be seen. Nevertheless, the mRNA changes of some genes might tell us something about GA’s molecular mechanisms of action."
I am not an expert in this area. However, it is clear from the paper that their data was not repeatable over time. Teva researchers themselves don't understand the mechanism nor the relevance of GE data. Is the FDA too chicken to call "rabbit hole"?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852967/
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