Avid Bioservices Inc (CDMO)

[goodJohnhunting]

IFU,

What is a "Myocardial Infraction"? eom

Since no one answered, what is common knowledge here among qualified posters, that could have easily replied, I'll answer it, I guess since you asked me...

Myocardial Infraction is commonly known as a heart attack. Oftentimes, in either a trauma setting or among healthcare personnel, it's shortened to (MI) or (AMI) which stands for acute, or sudden heart attack..

In a previous post, I've addressed how Bavituximab might play a roll as a diagnostic of MI, and potentially treatment..

Bio,

As you might know, a cellular membrane contains a lipid bilayer. In recognition of this, wouldn't all released microvesicles contain cargo such as lipid particles? Wouldn't a percentage of this cargo be PS?. In my opinion, and understanding yes they would..

Signaling an immune response to inflammation involves host-pathogen interface, better known as cell to cell communication. This type of interface would be necessary in order to (A). Facilitate an immune response, (B) Delineate cell phenotype, (C) Initiate gene transcription. etc...

A pathway in which a cell facilitates these communications is done by releasing microvesicles into an extracellular environment. These vesicles would then be up-regulated by immune facilitators, such as phagocytes, macrophages, dendritic cells, etc.. These microvesicles carry with them predisposed receptors, dependent upon which type of response is necessary, such as an inflammatory response.

Once these microvesicles are meet with their target facilitators, in this case dentritic cells, they are ingested. dentritic cells would then release signaling chemicles, such as cytokines to coordinate an appropriate immune response. In this case it would be an inflammatory response.

Let me tie this all together now, and answer your question;

Quote:
"but I believe its possible since we know that exosomes can have flipped-PS, maybe this leads to a future trial of adding a PS Targeting agent for heart disease?"


A blood test for heart disease or heart damage is often preformed, as certain biomarkers are released in response to this damage. Such test include, CPK isoenzymes or myoglobin, and or better known, troponin test.

Where you find troponin you will find inflammation, and be sure that an immune response will follow, as it takes a cascade of intracellular signals to release troponin proteins. It's impossible to give directives to cardiomyocytes without first facilitating a chemically induced response to inflammation. Facilitating an immune response to heart damage starts with microvesicles/exosomes released from cardiomyocytes.

So to answer your question, yes. The potential is unlimited in regards to PS targeting and heart disease..

All the best,
John

http://investorshub.advfn.com/boards/read_msg.aspx?message_id=102235376

I hope that answered your question? Or maybe left you with more questions? :)

All the best,
John