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Re: None

Monday, 06/30/2014 9:37:32 PM

Monday, June 30, 2014 9:37:32 PM

Post# of 346654
Upcoming Events page updated... the summer is heatingupupup up a bit out in Tustin. Two breast cancer conferences within 45 days? I don't ever recall two breast shows that looked this close and this good... : ) odds of BTD here just increased I'd say

http://ir.peregrineinc.com/events.cfm

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Events & Presentations
Upcoming Events

Jul 17–19, 2014 13th Annual International Congress on the Future of Breast Cancer
Location: Huntington Beach, CA


Jul 31–Aug 2, 2014 15th Annual International Lung Cancer Congress(ILCC)
Speaker: Jeff Hutchins, Ph.D., Vice President of Preclinical


Aug 11–12, 2014 Cambridge Healthtech Institute's 2nd Annual Immunomodulatory Therapeutic Antibodies for Cancer Discovery and Development of the Next Wave of Checkpoint Inhibitors

Phosphatidylserine (PS) Targeting Antibodies Enhances Activity of Immune Checkpoint Inhibitors by Repolarizing Immunosuppressive Immune Cells Populating the Tumor Microenvironment

Jeff Hutchins, Ph.D., Vice President, Pre-Clinical Development, Peregrine Pharmaceuticals

PS is a phospholipid normally residing in the inner leaflet of the plasma membrane and becomes exposed on cells of the tumor microenvironment, promoting an immunosuppressive microenvironment (MDSCs, immature dendritic cells, M2 macrophages, anti-inflammatory cytokines). Bavituximab, a PS-targeting antibody, repolarizes this microenvironment, enhancing innate and adaptive anti-tumor immunity. We demonstrate PS targeting antibodies enhance anti-tumor activity of multiple forms of standard therapy, including anti-CTLA-4 and anti-PD-1 checkpoint inhibitor antibodies without the side-effects of systemic immune activation.


Sep 4–6, 2014 ASCO 2014 Breast Cancer Symposium
Location: San Francisco CA

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"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline."
-- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!

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