Monday, June 30, 2014 9:37:32 PM
http://ir.peregrineinc.com/events.cfm
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Events & Presentations
Upcoming Events
Jul 17–19, 2014 13th Annual International Congress on the Future of Breast Cancer
Location: Huntington Beach, CA
Jul 31–Aug 2, 2014 15th Annual International Lung Cancer Congress(ILCC)
Speaker: Jeff Hutchins, Ph.D., Vice President of Preclinical
Aug 11–12, 2014 Cambridge Healthtech Institute's 2nd Annual Immunomodulatory Therapeutic Antibodies for Cancer Discovery and Development of the Next Wave of Checkpoint Inhibitors
Phosphatidylserine (PS) Targeting Antibodies Enhances Activity of Immune Checkpoint Inhibitors by Repolarizing Immunosuppressive Immune Cells Populating the Tumor Microenvironment
Jeff Hutchins, Ph.D., Vice President, Pre-Clinical Development, Peregrine Pharmaceuticals
PS is a phospholipid normally residing in the inner leaflet of the plasma membrane and becomes exposed on cells of the tumor microenvironment, promoting an immunosuppressive microenvironment (MDSCs, immature dendritic cells, M2 macrophages, anti-inflammatory cytokines). Bavituximab, a PS-targeting antibody, repolarizes this microenvironment, enhancing innate and adaptive anti-tumor immunity. We demonstrate PS targeting antibodies enhance anti-tumor activity of multiple forms of standard therapy, including anti-CTLA-4 and anti-PD-1 checkpoint inhibitor antibodies without the side-effects of systemic immune activation.
Sep 4–6, 2014 ASCO 2014 Breast Cancer Symposium
Location: San Francisco CA
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"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
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