Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

The Connection Between Inflammation, Angiogenesis, and Cancer in Migration Wordpress.com, Dan | January 31, 2007

Excerpt:
"Nature Reviews Cancer has an interesting opinion piece on tumor microenvironments, and how addressing cancer therapy as a problem of chronic inflamation may be an effective therapeutic framework for limiting tumor growth."

"There is a discrete order of events in physiologically acute inflammation and repair10 (Fig. 1a). However, these events become chaotically disorganized during chronic unresolved inflammation and carcinogenesis (Fig. 1b). This chaotic local microenvironment has led to the suggestion that tumours are ‘wounds that do not heal’11. The constant disruption of homeostasis by proliferating epithelial cells produces a chronic inflammatory reaction, which is an abortive attempt to re-establish homeostasis through tissue remodelling12. However, the classic players in acute inflammation (granulocytes, macrophages, endothelial cells and fibroblasts) that ordinarily lead to the resolution of a wound through an orderly series of events, instead react paradoxically to the presence of dysfunctional epithelial cells by promoting their survival and replication12. This process includes inflammatory angiogenesis."

Article at:
http://migration.wordpress.com/2007/01/31/the-connection-between-inflammation-angiogenesis-and-cancer/