Alzheimer's compound gradually lowers amyloid in mice brains in Fierce Pharma, June 3, 2014 | By Emily Mullin
Excerpts: "The researchers believe that a drug like 2-PMAP that could be taken daily over many years to gradually lower the production of amyloid ß may be an effective prevention strategy for Alzheimer's.
"What we want in an Alzheimer's preventive is a drug that modestly lowers amyloid ß and is also safe for long term use," says Dr. Martin Sadowski, associate professor of neurology, psychiatry, and biochemistry and molecular pharmacolog"
"Dr. Sadowski's team came across 2-PMAP after screening a library of compounds and finding that, even at low, nontoxic concentrations, the molecule significantly reduced production of amyloid ß's mother protein, known as amyloid precursor protein (APP), in test cells and lowered amyloid beta levels by 50% or more.
The findings appear online in the journal Annals of Neurology."
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