Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain http://www.nejm.org/doi/full/10.1056/NEJMoa1310246?query=TOC Full PDF http://www.nejm.org/doi/pdf/10.1056/NEJMoa1310246 Only one major cardiovascular event was considered by the investigator to be related to the study drug, and it occurred in the placebo group.