Volume without price says accumulation, not manipulation. In the OTC game. In a darkside play. accumulation usually proceeds any possible manipulation play by a couple weeks. And indicates one should research changes in OS or new funding info. Many times the large volumes are just bottom fishers moving in, not insiders and friends loading before a VC driven run for profits.
IMO this is not the time to load up large. Could take a small starter position on hopes of possible run. But volume alone does not an attention pop make. Bottom fishers more likely, unless you find large amounts of new shares in big guys hands in your research.
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