Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability in Carcinogenesis, Italian Association for Cancer Research; Italian Ministry of Health; Project Oncology 2006 and Alleanza Contro il Cancro, University and Research; European FP6 Programme (LSHB-CT-2005-518167) Project Innochem; NOBEL project, Fondazione Cariplo., Francesco Colotta1, Paola Allavena2, Antonio Sica2,3, Cecilia Garlanda2 and Alberto Mantovani2,4,*
1Nerviano Medical Sciences, Nerviano, 20014 Nerviano, Milan, Italy
2Department of Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
3Institute of Pathology, University of Piemonte Orientale, 28100 Novara, Italy, 4Department of Translational Medicine, University of Milan, 20121 Milan, Italy, May 2009


Abstract:
"Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57–70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark."



Article at:
http://carcin.oxfordjournals.org/content/30/7/1073.full