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Thursday, May 29, 2014 4:18:46 PM
"stimulate mylodry(sp?)'s conversion to APC's"
He was talking about the ability of IL-12 to signal myeloid derived suppressor cells (MDSC) to differentiate into antigen presenting cells (APC). To accomplish anticancer immunotherapy, any treatment needs to overcome the strong immunuosuppression that exists in the tumor microenvironment. As tumors develop, MDSC accumulate and express molecules that inhibit the activity of immune cells that would otherwise recognize and remove tumor cells. IL-12 causes the MDSC to change into APC that activate the anticancer immune cells rather than inhibit them."
Does that sound right?
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