Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

NF-?B pathway activators as potential ageing biomarkers: targets for new therapeutic strategies in Immunity and Aging, Carmela R Balistreri*, Giuseppina Candore, Giulia Accardi, Giuseppina Colonna-Romano and Domenico Lio, Corresponding author: Carmela R Balistreri, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Corso Tukory 211, Palermo 90134, Italy, October 2013

Abstract:
"Chronic inflammation is a major biological mechanism underpinning biological ageing process and age-related diseases. Inflammation is also the key response of host defense against pathogens and tissue injury. Current opinion sustains that during evolution the host defense and ageing process have become linked together. Thus, the large array of defense factors and mechanisms linked to the NF-?B system seem to be involved in ageing process. This concept leads us in proposing inductors of NF-?B signaling pathway as potential ageing biomarkers. On the other hand, ageing biomarkers, represented by biological indicators and selected through apposite criteria, should help to characterize biological age and, since age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. In this report, some inflammatory biomarkers will be discussed for a better understanding of the concept of biological ageing, providing ideas on eventual working hypothesis about potential targets for the development of new therapeutic strategies and improving, as consequence, the quality of life of elderly population.

Article at:
http://www.immunityageing.com/content/10/1/24