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Re: biocqr post# 177564

Tuesday, 05/27/2014 4:44:14 PM

Tuesday, May 27, 2014 4:44:14 PM

Post# of 252564
BMY licenses “Probody” technology from CytomX Therapeutics (private) to develop drugs for specified oncology targets:

http://finance.yahoo.com/news/bristol-myers-squibb-cytomx-therapeutics-110000817.html

…CytomX will grant Bristol-Myers Squibb exclusive worldwide rights to develop and commercialize Probodies for up to four oncology targets including CTLA-4… Bristol-Myers Squibb will have certain additional rights to substitute up to two collaboration targets. Bristol-Myers Squibb will make an upfront payment of $50 million to CytomX and provide research funding over the course of the research term.

CytomX will also be eligible to receive additional preclinical payments and up to $298 million in future development, regulatory and sales milestone payments for each collaboration target, as well as tiered mid-single-digit rising to low-double-digit royalty payments on net sales of each product commercialized by Bristol-Myers Squibb.

Probodies are monoclonal antibodies that are selectively activated within the cancer microenvironment, focusing the activity of therapeutic antibodies to tumors and sparing healthy tissue. The unique selectivity of Probodies expands the therapeutic window for both validated and novel targets, and has the potential to create multiple new classes of safer and more effective therapies.


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