Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

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Chronic inflammation: An important factor in the pathogenesis of oral cancer in Dentistry IQ, no author, no date


Inflammation and cancer: historical overview:
The association between chronic inflammation with a variety of epithelial malignancies has been recognized since the observation of Virchow,1 who attributed tumor formation to chronic irritation in the 19th century. Examples of inflammatory processes linked with an increased cancer risk include inflammatory bowel diseases and colorectal adenocarcinoma, atrophic gastritis and gastric cancer, cholangiocarcinoma related to chronic cholecystitis, and esophageal carcinoma following reflux esophagitis.2-4 As the concept of inflammation involves reaction to microbial agents, cancers caused by chronic infection, causing chronic inflammation, can be added to this list of examples. These infectious agents include Helicobacter pylori (chronic gastritis linked with adenocarcinoma of stomach and B-cell lymphoma), Epstein-Barr virus (non-Hodgkin lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, and natural killer-T cell lymphoma), human papillomavirus (anogenital carcinoma and perhaps oropharyngeal carcinoma), hepatitis B or C virus (hepatocellular carcinoma), human herpesvirus 8 (Kaposi sarcoma), and schistosoma haematobium (squamous carcinoma of urinary bladder).5,6

Article at:
http://www.dentistryiq.com/articles/gr/print/volume-2/issue-1/original-article/chronic-inflammation-an-important-factor-in-the-pathogenesis-of-oral-cancer.html