Biotech Values

[genisi]

OT - Why females get MS at 4X males: S1PR2

In other recent papers and the original manuscript of the one you linked to, the female/male ratio in MS is estimated to be near 3:1 and may be increasing according to some reports. On the other hand, males have usually a more rapid progression and worse outcome.
One more general caution about the Klein group results in humans is data came from only 10 MS specimens and while quantitative IHC showed significantly higher levels of vessel-associated S1PR2 in patients with MS compared with that in patients without MS, in female vs males it was only a trend.