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Humira, The 10 best-selling drugs of 2013, March 25, 2014 in Fierce Pharma

Excerpt:
1. Humira
The companies: AbbVie, Eisai
[b]Worldwide sales: $11.02 billion

AbbVie ($ABBV) rides Humira sales hard; the anti-inflammatory drug has churned out the majority of the company's revenue since Abbott Laboratories ($ABT) spun it off last January. In AbbVie's first full year on its own, its $10.7 billion from Humira made up 57% of overall sales, which tallied $18.8 billion.

Luckily for AbbVie, Humira's growth has shown no signs of slowing. Thanks to a score of additional indications as a treatment for ailments the likes of plaque psoriasis, Crohn's disease and ulcerative colitis, sales have nearly doubled since 2010's $5.5 billion haul. And in 2013 alone, Humira posted double-digit gains each quarter for AbbVie, with revenue increases from the year-ago period coming in at 16%, 13%, 19% and 13% in Q1, Q2, Q3 and Q4, respectively.

But no drug can stay at the top forever; Humira's patent protection is set to expire in 2016. And somewhat unsurprisingly, Humira's success has put a target on its back for biosimilar developers hungry for a piece of its revenues. A recent report from Moody's named AbbVie's drug as among the most sought-after prototypes for biosimilar copies; Novartis' ($NVS) Sandoz, for one, is well on its way with a version, starting Phase III trials in mid-December.

But until copycats hit, AbbVie plans to keep things going in the same direction. The company expects $19 billion in 2014 revenue, with Humira sales figuring in heavily.

Article at:
http://www.fiercepharma.com/special-reports/humira-best-selling-drugs-2013#ixzz31iEwpq1V


Humira Adverse Effects:
Common side effects of Humira subcutaneous:
Bacterial Infection of Blood or Tissues affecting the Whole Body Severe
Cellulitis Severe
Acute Infection of the Nose, Throat or Sinus Severe
Lupus-Like Syndrome Severe
Fever Severe
Rash Severe
Infection Severe
Extreme Loss of Body Water Severe
Sinus Irritation and Congestion Less Severe
Head Pain Less Severe
Feel Like Throwing Up Less Severe
Stomach Cramps Less Severe
Signs and Symptoms at Injection Site Less Severe
Infrequent side effects of Humira subcutaneous:
Multiple Sclerosis Severe
Cataracts Severe
Abnormal Increase in Red Blood Cells Severe
High Blood Pressure Severe
Extremely High Blood Pressure Severe
Heart Attack Severe
Inflammation of the Covering of the Heart or Pericardium Severe
Fluid in the Covering of the Heart or Pericardium Severe
Atrial Fibrillation Severe
Complete Stoppage of the Heart Severe
Abnormal Heart Rhythm Severe
Chronic Heart Failure Severe
Accumulation of Blood in Subdural Space Under Skull Bone Severe
Formation of Blood Clots in the Leg Veins Severe
Shingles Severe
Pneumonia Severe
Asthma Severe
Bronchospasm Severe
Liver Tissue Death Severe
Gallstones Severe
Bleeding of the Stomach or Intestines Severe
Bacterial Infection of the Kidney and Renal Pelvis Severe
Kidney Stone Severe
Inflammation of the Bladder Severe
Urinary Tract Infection Severe
Feeling Faint Severe
Flu-Like Symptoms Severe
Fluid Retention in the Legs, Feet, Arms or Hands Severe
Fast Heartbeat Severe
Heart Throbbing or Pounding Severe
Trouble Breathing Severe
Chest Pain Severe
Broken Bone Severe
Infection caused by a Fungus Severe
Reactivated Tuberculosis Severe
A Malignant Pigmented Mole or Tumor Severe
Malignant Lymphoma Severe
Breast Cancer Severe
Tumor of the Skin Severe
Decreased Function of the Parathyroid Gland Severe
Increased Antibody Proteins in the Blood Severe
Accumulation of Ketones from Abnormal Metabolism Severe
Red Lesions of Skin caused by Group A Streptococcus Severe
Deficiency of Granulocytes a Type of White Blood Cell Severe
Decreased White Blood Cells Severe
Acquired Increase of Red Blood Cells Severe
Escape of Fluid into the Lungs Less Severe
Inflammation of the Esophagus Less Severe
Inflammation of the Lining of the Stomach and Intestines Less Severe
Bloody Urine Less Severe
Irregular Periods Less Severe
Bacteria causing an Infection in the Joints Less Severe
Arthritis Less Severe
Backache Less Severe
Muscle Weakness Less Severe
Pain in Arms or Legs Less Severe
Cramps Less Severe
Bone Disease Less Severe
Involuntary Quivering Less Severe
Throwing Up Less Severe
Pelvic Pain Less Severe
Impaired Wound Healing Less Severe
Numbness and Tingling Less Severe
Inflammation of the Lining of a Joint Less Severe
High Cholesterol Less Severe
High Amount of Fats in the Blood Less Severe
Confused Less Severe
Rare side effects of Humira subcutaneous:
Demyelinating Disease Severe
Guillain-Barre Syndrome Severe
Sudden Blindness and Pain Upon Moving the Eye Severe
Relapse of Hepatitis B Infection Symptoms Severe
Drug Therapy that Worsens or Flares Psoriasis Severe
Pancreatitis Severe
Hepatosplenic T-cell Lymphoma Severe
Worsening of Chronic Heart Failure Severe
Blood Clot in Lung Severe
Heart Failure Severe
Stroke Severe
Vasculitis Severe
Inflammation of Blood Vessels in the Skin Severe
Blood Clot in a Deep Vein Severe
Legionnaire's Disease Severe
Lung Fibrosis Severe
Appendicitis Severe
Diverticulitis Severe
Hole in the Intestine Severe
Liver Failure Severe
Inflammation of the Gallbladder Severe
Erythema Multiforme Severe
Stevens-Johnson Syndrome Severe
Abnormal Liver Function Tests Severe
Infection caused by Coccidioides Fungus Severe
Type of Infection caused by Histoplasmosis Fungus Severe
Infection caused by Blastomyces Dermatitidis Fungus Severe
Life Threatening Allergic Reaction Severe
Giant Hives Severe
Reaction due to an Allergy Severe
A Fungal Infection that Occurs Under Certain Circumstances Severe
Active Tuberculosis Severe
Sarcoidosis Severe
Infection caused by a Protozoa Organism Severe
Malignant Tumor or Cancer Severe
Leukemia Severe
Infection caused by the Bacteria Listeria Monocytogenes Severe
Acquired Decrease of All Cells in the Blood Severe
Low Blood Counts due to Bone Marrow Failure Severe
Decreased Blood Platelets Severe
Hair Loss Less Severe

Humira Side Effects list at:
http://www.webmd.com/drugs/drug-64713-Humira+SubQ.aspx?drugid=64713&drugname=Humira+SubQ&pagenumber=6