Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

The 10 best-selling drugs of 2013, March 25, 2014
Enbrel, The companies: Amgen, Pfizer, Takeda, Worldwide sales: $8.776 billion

Excerpt:
Enbrel was the first of its kind, a TNF (tumor necrosis factor) inhibitor to treat autoimmune diseases, and its distinction allowed it to become one of the best-selling drugs in the world. It was first approved by the FDA more than 15 years ago in 1998 for treating moderate to severe rheumatoid arthritis, but it has racked up four more approvals in the U.S. since then and the revenues to go with it. Amgen bought its developer, Immunex, in 2002 for about $16 billion, a deal that seemed incredible to some at the time, but that in retrospect was a bargain.

Article at:
http://www.fiercepharma.com/special-reports/enbrel-best-selling-drugs-2013#ixzz31i0Trg4K

Serious side effects of Embrel at Embrel website:
Serious side effects of ENBREL
Risk of infection. ENBREL can lower the ability of your immune system to fight infections. Some people have serious infections while taking ENBREL. These infections include tuberculosis (TB), and infections caused by viruses, fungi or bacteria that spread throughout their body. Some people have died from these infections.
Risk of cancer.
There have been cases of unusual cancers in children and teenage patients who started using TNF-blocking agents at less than 18 years of age.
For children, teenagers, and adults taking TNF-blocker medicines, including ENBREL, the chances of getting lymphoma or other cancers may increase.
People with rheumatoid arthritis or psoriasis, especially those with very active disease, may be more likely to get lymphoma.
Previous Hepatitis B infection. If you have been previously infected with the hepatitis B virus (a virus that affects the liver), the virus can become active while you use ENBREL.
Nervous system problems. Rarely, people who use TNF blocker medicines have developed nervous system problems such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes.
Blood problems. Low blood counts have been seen with other TNF blocker medicines. Your body may not make enough of the blood cells that help fight infections or help stop bleeding. Symptoms include fever, bruising or bleeding very easily, or looking pale.
Heart failure including new heart failure or worsening of heart failure you already have. New or worse heart failure can happen in people who use TNF blocker medicines, like ENBREL.
Psoriasis. Some people using ENBREL developed new psoriasis or worsening of psoriasis they already had.
Allergic reactions. Allergic reactions can happen to people who use TNF blocker medicines.
Autoimmune reactions, including:
Lupus-like syndrome. Symptoms include a rash on your face and arms that gets worse in the sun.
Autoimmune hepatitis. Liver problems can happen in people who use TNF blocker medicines, including ENBREL. These problems can lead to liver failure and death.

Embrel webpage:
http://www.enbrel.com/possible-side-effects.jspx?WT.z_co=A&WT.z_in=OTH&WT.z_ch=PDS&WT.z_se=G&WT.srch=1&WT.mc_id=A_OTH_PDS_G