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Re: Titan V post# 12589

Monday, 05/05/2014 11:43:31 AM

Monday, May 05, 2014 11:43:31 AM

Post# of 48316
So, you science guys:

I've read the PR this morning about 4 times. Obviously, it is great news. However, I need a little help understanding its significance.
My understanding is that this mouse study confirms IL-12's systemic ability to fight untreated tumors. What I don't understand is the significance of this study on ONCS. Two points I'd like help with:

1. Its seems like we have have results that show systemic responses in human trials in both Phase 1 and 2 throughout multiple studies. Therefore, I read this study as confirming in mice what we already know in humans.

2. I thought the Old Dominion Study with Heller was to explore results with mice using combination therapies such as anti-PD-1. I didn't see anything related to combination therapy at all.

I know this is a limited reading of the results today, so if someone could help me understand the significance of this study it would be greatly appreciated.