Good Afternoon to All,
Since everybody seems to be in a good humor today, I submit the following:
Have been away for a long vacation on the planet Mongo. Mongo is the planet furthest from the Earth in the known universe. I am happy to report that on Mongo their favorite game is "Six Degrees of Separation from the Company PPHM on the Planet Earth". The Mongoloids are fantastic players of this game.
Mongo has two suns in its solar system so their beach resorts are fabulous. Unfortunately, it is a favorite resort now for all the white mice that have been treated by PPHM. You can't get a lounge chair at the pool or on the beach because they are taken by the white mice that are no longer afraid of Melanoma. On this last vacation I noticed that not only are the mice laying out in the sun but they are also smoking. I take it something has happened on Earth that makes them no longer afraid of NSCLC.
What the Mongoloids enjoy even more than "Six Degrees" are "facts" that no one else has previously talked about. Since they knew I was returning to my day job on Earth, they whispered what they thought was an interesting new fact in my ear. They hope I will trade it for other new facts that the earthlings can dig up. They already have enough innuendo, speculation, but, they are still craving new facts.
BTW-- Every thing is free on Mongo.
Mongoloids understand "value" but they have no conception of "price" and so they can't conceive of "day trading". They never discuss it. Though IMO there is nothing wrong with a discussion of price or with day trading, my observation is that this flaw in Mongoloid thinking makes them very clear headed and efficient. (LOL)
The Mongoloids whisper the following new fact. :
This recent paper at AACR that used SBRT and Bavi vs NSCLC in mice and for all practical purposes eradicated the disease after 184 days was done on "nude" mice or "athymic" mice. That is to say the mice had fully developed immune systems EXCEPT for the fact that they have no TCells. Since TCells are the killer elite of the immune system this is a "particularly interesting result". Just think about this. To repeat, PPHM achieved this result without TCells.
IMO this is black and white prima facie evidence of the difference in MOA of bavi upstream vs all downstream checkpoints. This IMO makes the argument stronger that bavi is the perfect combo drug since it would be uncompetitive to offer any downstream treatment alone.
Some Downstream checkpoint drugs target PD1/PDL-1 and CTLA-4 . They are designed to counter TCell suppression and release existing TCells to do their work. As you already know Bavi enhances the chain of immuno response that produces more active TCells. So when TCells are added back into the equation this story just gets better.
IMO one step closer to "collaboration".
If you really want to "Wook something up" just imagine--- an immuno therapy that gets 100% response in white mice (NSCLC) without a single TCell---wow.
Best Regards,
RRdog
