Largest Holders as of Apr 5, 2007 [The % ownership includes options exercisable now or within 60 days of 4/5/07, the cut-off date in the annual-meeting proxy.] <A HREF="http://www.sec.gov/Archives/edgar/data/904973/000120677407001018/gtc_nps.htm" target="_blank">http://www.sec.gov/Archives/edgar/data/904973/000120677407001018/gtc_nps.htm</A> LFB Biotechnologies 19.8% William Harris Investors 8.9% Genzyme 5.5% Geoffrey Cox 1.2% All directors/officers (excl. LFB): 2.6%