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Post# of 253566
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rfj1862

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rfj1862

Re: gofishmarko post# 41954

Monday, 02/12/2007 1:03:40 PM

Monday, February 12, 2007 1:03:40 PM

Post# of 253566
VIII is not an obligate component of the coagulation cascade, eg, it can be bypassed (thus FEIBA: Factor Eight Inhibitor Bypassing Activity).

On the other hand thrombin (IIa) is absolutely necessary for coagulation, as is Xa.

Think of it like a tree with coagulation initiators at the top and the coagulation event at the base of the trunk. Inhibiting VIII is like cutting off one of the branches; inhibiting IIa is like cutting down the entire tree.
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