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Possibly the next steps for AGN will include Cascade Chemistry and their manufacturing and testing of the IV form of Ifenprodil. Initially (Mar 2020) it was stated that the IV formulation could be used in both the IPF/CC and COVID Trials. Some progress has been reported during past Videos and maybe it would be important info...GLTA...
Actually I feel this will bring additional scrutiny and time consuming reviews. He works directly for NRX and their BIO of him is a bs FDA sentence only? Just his name and RLF together is F*U* seen on his 'pink slip'. No one will care what he does/did. Just flock to buy this stock, with no sec filings, right. We already have a 2B OS to fight. The data must/better be overwhelming, now...
One rotten "looking" apple could ruin the "impression" of the whole batch...
NRX is taking it serious apparently. How are we/they not affected by this?
Regulatory & Patient Advocacy Adviser
Mr. Pines previously served as Associate Commissioner of the US Food and Drug Administration.
That's the entire Bio? His job was what at FDA? GMAFB...
Duh...
" But at the same time that’s how little coverage the promising drugs are getting compared to what big pharma is getting....even if their results are garbage."
I agree with this statement. We will have to produce solid results for any decent coverage. The big pharma's are also making it harder to recruit. Not getting the SK data when we expected it has put us in the pack instead of leading it. Fanfare with 'garbage results' is still just garbage. Now for sure real Data maters...JMHO...GLTA...
23M shares voted for 3 year review of salaries, 8M voted for every year. At least they took their "backpay" in shares to do it.
NOW what will they do, new offering 5M @$.10? Can't let the company go BK and lose the free money.
They couldn't sell the Voraxials (didnt try) or get enough 'precision machining work" (real machinists gone) and we dont know about the face shields selling, in FLORIDA??? OMG...
Turning hubs? How about back to Municipals' waste and clean water needed after laura and now Nana on the way? Maybe the .Gov will give them some work... Still cant see how SLB deal couldnt/wasn't leveraged or used as a reference to sell Voraxials,,,SLB!!!
We've been screwed since John Jr sold to SLB?. Well really since John Sr allowed Jr to F*U* the Google spill contest. Isn't that Voraxial 800 still owned/parked?
What will the share count (1.4B Float and 2.2B outstanding) look like IF there is an upgrade to the OTC. R/S? Stuck 40k @$.5 so I'll just stick around hope. Late boat ride Hmmmm. Does anyone see $1+ in the near future.?. ...GLTA...
Yes, News is the Key. Some legitimate sourced DATA and PRs to get back to the 100M+ share days and us late boat riders will see our double or Trips. Maybe even a freerent situation.
Remdesivir was developed at Wuhan Virologic Institute with Gilead. The research was on SARS. SOMETHING happened and the Virus escaped for the world to enjoy. China built a 10000 bed hospital in 9 days to treat patients and closed the areas trying to hide and possibly contain the disaster/epidemic. Foreign Visitors carried the disease thru ships and planes as they were expelled from the country.
Many people, me included, blame Gilead,,, and their crap doesn't even work,,,JMHFO...
I hope my late boat can ride this to $2+...GLTA...
This is a speculative OTC BioPharma with a drug that has a different attack on lung issues and possibly COVID too.
Buy those other stocks, your money, your decisions, your DD. Some here did, I did, late. Bought much more here recently, others also claimed to have bought or are holding too. We all must feel that this has a good Reward to Risk,,, Solid science in Trials.
What is your opinion and DD on those questions you asked, links?
Plenty of DD posted here, timelines, scientific data, links to Interviews and Opinions of what it all May mean. Just my humble Opinion...
S Korea now increasing COVID cases to March levels. Rest of the world too...
Dosing patients???:
in S Korea Covid Trial,
IPF / CC Trials in NZ and Australia, with recent spike 5k+ COVID still hospitalized,
Multinational COVID Trials' enrollments progressing and increasing at warp speed. Romania and Philippines having COVID spikes to March levels +. US COVID cases leading the world with failure of leadership.
Plenty of room for differing treatments and combinations of treatments that will be Needed for quite some time. Recovery from COVID damage a leading issue now along with the fight for patient survival...GLTA...
https://en.yna.co.kr/view/AEN20200821002651320?section=science/medicine
8K-10k;
R/S 10/1, salary/management review every 3 years, they now have a majority of shares. Voraxial business?, face shields?, some precision machining?.
https://sec.report/Document/0001099910-20-000083/
Many of these being enrolled as patients are critically ill. Is there time to wait for dosing. Enrollment must equal dosing or the first patients enrolled might be dead. Comparison patients not getting dosed will also change condition between that length of time. It seemed implied but I didn't hear that exact statement of 'enrolled patients will be categorized randomly into treatment arms and trial will start for them at that point'. No way was it implied that all patients would wait and be categorized after full recruitment. Just how I heard it. ? ...GLTA...
There will be leaks of success. Look at what another stock is about 1 patient and 6 possible
How come you edited the article to exclude this.?
RLF-100 is not a new finding. It was discovered in 1970 by Dr Sami Said, a pulmonary medicine specialist. In 2001, US FDA gave RLF-100 an orphan drug designation to treat acute respiratory distress syndrome, and in 2006 for acute lung injury. US FDA also granted investigational new drug (IND) licenses for human trials of Aviptadil. But it has not shown significant progress in those trials in treating lung disease.
and this?
Dr Rahul Pandit, intensivist in Fortis hospital, however warned. “There is very little known. For us to prescribe a drug, we need to wait for scientific evidence,” he said.
medchem's detailed evaluation of Ifenprodil still stands as undisputed Science that is now being tested in Clinical Trials. Several of the posts included insights we all were thankful to read.
As said, stopped posting over other poster's controversies and delay related to the SK trials progress, PP's, related pps dip, IMO. Medchem never said shares were sold just stopped posting and stepped down from a moderator.
Rereading the sticky post and tracing those dates will show several deep posts and discussions.
The Science he detailed is still undisputed.
medchem has not posted anywhere since May, I hope for best health to all..IMO...GLTA...
That's why there are clinical Trials with specific goals, specific administrating of the drug, expected outcome, requirements and exclusions of patients and then actual outcome review.
Excessive claims on social media like this is damaging this stock's credibility, almost as much as the huge OS count and (lack of) financials. IMO.
The Drug's story will sell itself. Excessive traders flipping for pennies will subdue the PPS. I hope for a double from the $.5s with good early data...
2nd wave hitting all around...Midday mid week AM and interview tomorrow too...
https://en.yna.co.kr/view/AEN20200818003252315?section=science/medicine
You dont have to worry as much about some of the 1.4B float being in the hands of flippers, its the 1B + from the 'institutions' that need to finally now maybe make a profit too.
With good news this could be a triple from here. A buyout could be ?
I'm confident you have made a Good investment and plan with that freerent. I 2x my position here last week. Salute...
The Race to join the Battle against COVID. Ifenprodil already proved to reduce H5N1 mortality 40%+. Beat all other tested drugs in that 'acid in the lung' trial.
Enrollment news;
Possible DATA news;
...GLTA...
Looks like this may be due to the connections Dr. Williams had in eastern Europe through the work at NASH. Great surprise with that Romanian segment of the International Trials in process.
Enrollments in the Philippines and USA should be filling quickly too. I would call this a Milestone for AGN in the race to fight the Cyclonites and prove remission (my word) with a treatment path during a COVID Virus and certainly in the Lung's healing as the infections abate.
Thanks to all for the discussions and DD. AGN doesn't need 500+ posts from the same folks yelling ***@$.05***cure***, congrats to all of us. BUT the Trials will prove what is effective and when. Real news will be all over a proven success. Positive DATA...
There will be plenty of room for collaboration and combinations of treatments. Even colquin +remdesivir (sp) +?+ combos were tried/pumped with discouraging results. There surely will be better combinations of treatments developed. Ifenprodil, +?...
.
Thank the stars, we have a relatively small OS count too with huge Reward to Risk.
Cancer drugs are much more expensive. Optivo = $8K per dose, Keytruda = $11k a dose and Ipilimamub is about $100k a dose. I know,
The whole treatment for Remdesivir is $4500 and $390 a dose. Pretty cheap but also not very effective, from the reading I've seen. 11%?
Drug production of these cancer drugs has been hard for the manufactures causing shortages, same as remdesivir which hinders common use more than the price. IMO . Of course remdesivie also has the Wuhan Virologic inst past during development. Very questionable but not discussed except from D Trump.
Avapidil is fairly inexpensive in comparison.
Cost link
https://www.usatoday.com/story/news/factcheck/2020/05/09/fact-check-price-didnt-push-remdesivir-over-hydroxychloroquine/3094440001/
Average 50M shares a day now. Partnerships are in work and a share subscription is currently in place with GEM for financing. They wont be paying $.5s... 22.1B OS with the support dwindling with the lower volume. $.03 to $.06 shares from GEM?
A double from here ($.5s) will take LOTS of effort and huge share trades. Great concept / drug / treatment possibly but that huge OS will be an issue. R/S? maybe.
Looks like even with a closed country to most foreigners/ the strict distancing and enforced Mask requirements in South Korea there are 'clusters' and probably increased hospitalizations... Most patients probably dont want to wait for a proven and tested Vaccine.
Calling Dr. Sik please...GLTA...
MC went from $100M to $600M ++ and the major dilution has already happened @$.05. Even 100m shares is relatively small increase yet yields $30M, plenty for Trials...?
Overall AGN has a fairly low outstanding share count. Even fully diluted with all options/warrants it's 'only' 196M. Some companies have alot more and they may not have the 'investor' potential we do, IMO. Bought the boat I missed and added the same $ in this one too, last couple days. 400% here with 200M shares could be a flash but might be an epic effort if there was 2B shares, IMO.
Great news being published...GLTA...
The Video speaks for itself, answered my question of the Trials seeking less ill patients. When/if(?) Partnerships of Major Pharma after initial results to manufacture a supply.
Doesn't need the excessive Bloviating. Folks aren't stupid. Flagrant, but there's my Buddy, equal callouts to all observations, then posted at risk if needed. Walking in my shoes, you now might make a good drafted Lt. IMO.
Could benefit with a combination drug that has NMDA antagonist effects, different from just trying to wipe up the "spilt milk".
I have read that Cascade * in Oregon is working on the IV application, which should be done by now or soonest. Plenty of planned and easy manufacturing of the pill forms, at least. Didnt they also buy/reserve a large supply too?
A flying COVID stock claims to be able to only produce 200k doses near term, even with fore seen partnerships. Manufacturing enough doses to supply a large demand may be an issue for other COVID remedies.?...GLTA...
Rent free now? Late to the boat but Never said never. Didn't expect to have my $.40s filled. Now I really dont expect to see it ($.4s) again. `
Q. another board...GLTA...
That "paid for" research and "Data" is way overdue...It's 'assumed' that is due to the successful early attack on COVID in their country...GLTA...
Rent free +,+, is where we all want to be.
I wondered why the CEO would allow the SK Trial to continue or just now see Dr. Sik's registrations. The record 'to date' has been dismal from what info we have been given. Dr. Sik is a RoK. Something about their culture gives me hope. Rather die than 'lose face'. A South Korean surprise is a possibility. Soon IS important (critical?)...JMHO...GLTA...
D Rump fully believes whatever Putin says. Sen Bob Dole would sh** himself too to see the current buddy system...JMHFO...
Could be a surprise, seem like this sets it up...Maybe.
Other bids closed on dip this AM. Wish I was at that decision point. Never said never..GLTA...
What does this mean concerning South Korea? *COVID* Severe Pneumonia/change?
https://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=17062
PS update, thought it was new news
2B OS...Lots of $.05 shares. When your up 400% sell 1/4 and the shares are free...
Gilead was working at the Wuhan Virologic Inst researching Viruses, this is where they developed Remdesivir. "Funny" at the same time COVID19 was released and China built a 10000bed hospital in like 9 days... Google it...
For a 5% ownership, wouldn't that purchase have to be over 105,000,000 @ 2.1 B outstanding?
Smaller buys compared to larger sells? Looks like this wont come close to the last days volume. 2B OS...Many @ $.05.?. Canceled my $.5s and maybe will wait a couple days. Yea, I'm sure those $.05 - $.20 holders wont take profits seeing the slowing action. JMHFO... Same with Institutions...
Replace Remdesivir? Hmmmmmmmm. Outlandish claims damage the story, IMO.
How about a few other's, IMOs? People aren't stupid and can Invest with their own DD if the story is strong enough. It has to sell itself. It May be ONE of the answers to COVID. Let the Trials Prove it.
Yea, I thought the Siri Appl stuff was pretty funny too. GLTY Sir. Same folks trying for 1000 posts / day. Long day ahead...glta...
It would be nice to have Dr Sik release info on how that trial and patients are doing. New sites last month. Since May for enrollment. Would be timely info to have something accomplished for the price.
What about Philippines? Did Novotech scam this too?
IPF/CC Trials in Australia/NZ must have moved way past 'First patient dosed'.
Florida Recruiting of patients? Every 3 patients, one for each arm dosing?
Other site location enrollments in Hotspot areas?
CANADA?
Other targeted US States thru GVI?
Rapidly Increasing number of Hospitalizations, the ball is rolling, and surely there must be many that would like to try almost anything. Surely the company does not want to overpromise again, but a Month (2) or more just seems pathetic results for this time sensitive issue. AGN is even allowing and seeking the sickest COVID patients.?...GLTA..
https://ycharts.com/indicators/us_coronavirus_hospitalizations
3/4 B shares traded since 8/4, alot of folks still holding $.05 shares as a lot of traders was the recent Volume. About 1.5B shares being held of those $.05 shares. Hype/News runs the stock up and the huge OS holders paint red, green for them.
Said I wasn't chasing this at $.80s but have orders <=$.5. Obviously not as large as I would of @ $.15.
Lots of confidence in this group, good. I caution about overexuberance, existing facts, other drugs expected data and OS/MC realities...GLTA