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Jewish Lightsabers are the future. Forget that silly pharma pipeline.
Well, we would have booked $1M for the start of a phase 3 per the terms of the deal so it isn't a phase 3.
They're running a phase 2 now aren't they? So you're not talking about starting a phase 3 until 2024. That will run over a year.
A measly 200x resulting in the largest pharmaceutical buyout ever?
Hell no. Prurisol alone was worth $15B.
Yeah.
Shareholder $$$$$ for Leo and Jane.
Governement $$$$$ for DeGrado and UCSF.
No $$$$$ for shareholders though.
Do we ever set a deadline on this investment or do we just keep cheering through 2030, 2040, and beyond? One preclinical news cycle to the next, year after year, decade after decade.
As the great ScottSmith once said: "Decades to death!"
It's disgusting.
How many successful clinical trials have we run since she started here?
How much of our clinical portfolio is remaining since she started here?
In my opinion Ehrlich needs her here to maintain the facade of a functional biotech company. Not that it's helping much....but if all you have in "senior management" is a CPA as CEO, CFO, and Chairman of the Board (First of his Name, Slayer of Shareholders) it doesn't look good.
You say that like Leo and the longs are on the same team. I'm not so sure any more.
Never a thought that BP's evaluation of our pipeline is more accurate than this board's? There are dozens of them and they're all very good at carefully choosing and acquiring candidates for large sums of money.
Why would Leo pull back all of the money he loaned the company? Why would he give away half our cash to a little known Israeli company named BeaMed. If your theory is true then we needed that cash to go it alone.
Snay, tuck those shares away and see where the company is in 2031. We'll have either succeeded or Leo will have drained everything from the company with his salary by then.
You gotta ask yourself. If BeaMed is so great, why did they sell 1/3 of their company to IPIX for $4M?
If IPIX's pipeline is so great, why did they give up half their cash to buy 1/3 of BeaMed?
I heartening seeing people continue to throw darts at the board after over 8 years of posting with the stock down 98% in that period.
Hope you get it right one of these days.
B is many years from market if it ever makes it.
If Leo could get $405M for Brilacidin/IPIX he would take it in a heart beat. He has over 20 million shares and his family has a few million more among them. Why would be over $15M just for him.
Instead he prefers to hold $600K in stock and leach $500K/year? Come on.
Wow. That doesn't even cover a one bi-weekly payroll at IPIX.
I have no doubt this deal will be the genesis of a rapid climb to a billion dollar market cap.
I'm pretty sure everything of value relating to fungi was licensed to Fox Chase.
If you're chasing down PRs put out by Polymedix about preclinical compounds from 2012 that haven't been mentioned in 8 years of 10Ks...well...good luck, hope you're right.
I think we're done with drug development at this point. We're now a holding company for the following:
2-6% royalty on Brilacidin for Ulcerative Proctitis (AlfaSigma)
6% royalty on Brilacidin for anti-fungal (Fox Chase)
Minority stake in BeaMed.
Possibly a deal for B-OM at some point.
What other defensin mimetic antifungals are in IPIX's library of compounds?
IPIX only has one compound.
Leo would take whatever stock price is required to value his stock at $4M. Otherwise he can just sit and collect the $4M as $500K/year salary.
Leo's shares aren't worth much and everyone but IPIX investors know that. Leo knows that as well. This company is a salary to him.
A little over $2/billion.
We have just under 500M shares.
My question to you was what do you think we have in our pipeline that is going to generate billions per year in sales. Keep in mind we pretty much have to partner anything to get it into phase 3 let alone to market. Our two current deals are for 2-6% royalties. So those indications would need $17-50B/year in sales for IPIX to see $1B/year in sales.
I don't think we'll ever see 10% of those numbers if we make it at all.
What is being sold for billions per year?
Just curious which indication you're talking about and when you think this will happen.
NNVC News: Notification That Annual Report Will Be Submitted Late (nt 10-k) 09/29/2022 12:20:40 PM
Hah. How coincidental. Thanks.
Birds of a feather as they say.
No, it's just that many have been here for 8 years watching the B trials get smaller and less successful over time. Now we're back to talking pre-clinicals.
Leo recently yanked his loan money out of the company and just gave half our capital to the laser company. That tells me all I need to know about how Leo feels about B.
I don't think there will be any further phase 2 drug development done by IPIX. I think we're just waiting to see if Squalus is a legit investment or if Leo takes an executive position there after the money dries up here.
You keep your eye on the science fair stuff though.
I stopped placing any new bets on it but my existing ones are hoping you are right.
You know...it has to actually go up at some point for that to be a good strategy.
I agree but any big spend will come after the recession. Any IPIX buyout could be quite lucrative from these prices but will probably be a few years off.
He's been here since it showed up on the Domino Analytics and Gilder boards like me. Late 2014ish.
I have to say...this is the first 6 month stretch I've preferred IPIX stock performance to that of the broader markets.
Progress!
Only because we can't.
I'd really prefer to know why he unilaterally invested half our working capital in some surgical laser venture in Israel we didn't have any clue about a year ago.
I've been following an investing in a "pharmaceutical company" for six year and now all of a sudden we're a venture capital family office run by a dictator.
IPIX has an accumulated shareholder deficit of over $120M per the last 10-Q. How much more money does Leo need to get us to a partnership or a phase 3?
Have you looked at the 8 year chart? That's what IPIX does. It digests company funds and poops out Leo's salary.
Naturally that results in a lower and lower share price over time.
When has Leo ever screwed the "short cartel"? He has steered this company from $4.80/share in 2014 to $0.039/share today. That's over a 99% loss in share price over nearly eight years.
He couldn't do a better job for them if he actually worked for them.
My speculation is that the MOA and disease between the IV and the nasal spray is so different that the two would not really be comparable.
The IV trial was high dosage in the blood stream against entrenched moderate to severe COVID.
The nasal spray/inhaler, I assume, is to for a prophylactic barrier in the nasal passageways that destroys viral particles before they attach.
There was previously some successful data using aerosolized defensins against MERS about a decade ago. However, with the volume of viral shedding, particularly in the Delta and Omicron variants, I'm not sure such a strategy would be all that effective against modern COVID strains.
Hopefully time will tell.
As you say though, it would be nice if they could spell things out very clearly for us especially when the company constantly changes course.