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Let us pray.
No BP is fretting over Brilacidin taking their revenues. If they were they'd offer Leo a few billion dollars and take Brilacidin.
Brilacidin is probably going to continue to do what it has for the last seven years and sit on the shelf until all of its patents expire. Leo will dust it off, rearrange it, make a new case for it, etc. Take into phase 3? Probably not going to happen.
IPIX partners for crumbs or it dies.
Go IPIX!
M&A is a very nice term for what would happen to us if Leo stepped down.
It's how you know Brilacidin is out of steam.
"What do we do with our $5M?"
Buy another Brilacidin. May we hype it to $4.93 again. Let me get out of this one alive.
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We had to go after COVID to raise cash if nothing else.
Recall prior to COVID we had $600K cash with $7M in liabilities. We had no way forward at that point for the other indications. We were heading to the auction block and it wasn't going to be pretty.
I had hoped our market cap would have ballooned to $1B+ like some of the other trash COVID stocks (HGEN, CYDY, RLT, etc.). That would have made raising quite a bit more money very easy but we didn't get lucky on that front.
Still, we're much better off with several million to work with than $600K.
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Was that before or after it went from $4.60 to $0.06?
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What is illegal about any of that? One of his primary duties is to sell the stock to investors to fund the company. Leo has a duty to shareholders, not future shareholders. If one is dumb enough to buy stock from the former CFO of Nanoviricides that's on them. I need someone to hold my bags and Leo is doing his darnedest to find them.
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Well...that's called a COVID pump on hopes that the drug would cure COVID.
The drug failed though and now the stock has returned to only 2x the pre COVID levels (we have almost twice as many shares now so it should be $0.03).
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Why would you say such a terrible thing? Leo has done nothing illegal.
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That's because our house turned into a pile of ashes a few weeks ago. We lost 80% this month. The NASDAQ lost 6% and other indexes even less.
There's pretty much nothing left to burn with a market cap of $20M after you subtract cash on hand.
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No, there is still hope. Don't crap on my heroes.
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Probably need a partner or another share authorization before we can start that.
My hope was we would have some silver-lining secondary data by now but it doesn't look like it's coming. That would have helped the stock back up to $0.20 or somewhere we could raise a little cash.
We'll see what happens the next couple months. Starting B-OM phase 3 with the cash we have leaves the company at great risk. It also would put Leo's pension, er...salary, at great risk as well.
My guess from here is that we will not start a phase 3 without one of the aforementioned events.
There is some comfort knowing we're already dead and it's all upside surprise from here. That or a merciful death. Both are ok.
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Nice. The possibility of a PR that possibly could move the stock price up/down. Exhilarating.
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Would be nice if he started deferring salary again. At least then it was plausible that he was looking out for shareholders. The least he can do after delivering failure after failure after non-progress. 0-2-1 on our last three phase 2 trials if you can count Kevetrin a draw.
Right now though it's definitely a case of the big dog eating first. If there's anything left on the carcass for investors great. If not, just good.
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If we don't get some kind of promise in the the form of silver lining secondary endpoints on the COVID trial, I think Brilacidin's chances as an antiviral have gone up in smoke. WHO is in government donor pockets...they aren't doing squat with Brilacidin unless Gilead or one of the big boys owns it.
I'm just hoping we can get some turd-tier pharma to put a few million upfront and cover our phase 3 OM for a chance at some real revenues.
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You mean the ABSSSI one that we've done nothing with since the trial ended seven years ago?
Or the UP one (not IV) that we licensed out for $420K? That is about to start another phase 2 trial which means it will be years before we see a $1M payment for starting phase 3.
Or the OM one (also not IV) that has been ready for phase 3 for two years now with no partner after engaging Locust Walk twice?
Which ones are you referring to Snay? So far B has only had one successful IV trial and it has sat on the shelf for seven years while Leo sold off 75% of that 2014 CTIX through dilution so the results/economics of it can't be that good.
Just looking for a $150-200M buyout so we can get a quarter or two per share out of this dumpster fire.
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With regard to Merck you are correct bit the milking will come. Future Facts as the old Scottsmith used to say.
With regard to B:
"But the ongoing context that is being created of "everything but B sucks""
Brilacidin is firmly in the "sucks" category right now. Considering we have not heard an update with any silver lining from secondary endpoints it's becoming clear in my mind it had almost no effect at the dosages given.
The only reason to hold hwre is that the market cap is so low that it is likely below lowball pipeline buyout numbers at this point and we're not going BK anytime soon.
Doesn't matter. The check has already been cut. The purpose has been served. The taxpayers have been milked. Now throw that mutagenic trash in the garbage before you get a baby with a third arm holding it's liver.
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It would be great if we had a drug that was useful against COVID. As of right now we don't though.
I can kill reduce the viral load of COVID by 99% in vitro too. Bleach works great. Where my SI *426* bois at?
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Can you cite that? I didn't see it in any PR.
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There's not much to post until we get secondary results and some direction from the company.
If nothing comes from the secondary results, then assuming we have enough money for OM phase 3 it's time to go to sleep and come back in a couple years.
The longer we have to wait for some secondary analysis the less likely there is anything good coming. I expected some summary secondary data last week as some of those metrics are very important going forward.
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All depends if the terms of the sale work out to better than what collecting his salary for another 20 years is.
He could just fire Jane, raise a few million more, and then collect $500K/year while running a 6 person trial every coupke years until he hands the operation off to his son.
Given the terms of the AS deal he may well opt for the salary.
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Yes, but investing $70K in a company prior to COVID data release is one thing. Investing $70K in a company after it releases failed COVID data is quite another.
Who would invest $70K in a dumpster fire? They obviously see something amidst the flames and burning diapers.
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Deep value investor? The market cap is absurd considering the pipeline.
And I'm not saying that as someone who believes we're a multibillion dollar company. I'm saying that as someone who thinks we're a multi-hundred-million dollar company which is ~10x from here.
Maybe if we ever get financing under our feet we can attack a billion again. But I'm pretty confident a $100M buyout would be easy to execute. The question is how much more can we actually get and what is Leo willing to part with his company for?
Given all the RBL research I think our preclinical anti-viral data and P53 potential in Kevetrin has to be worth twice the current market cap even if everything else is a complete fraud. That's not to mention the undeniably good ABSSSI results, the AS deal (worth roughly our market cap if it gets to market), or OM prospects.
And then there is still the potential that secondary data puts us in line for a combo partnership with Gilead. We don't need billions of revenue. A 3% cut of the $2B/year cocktail is $60M/year. That completely changes the company. An upfront payment of $50M and 2% royalty on Remdesivir/Brilacidin combo would be even better.
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No, but feel free to. If he truly has the ability to get shareholders out at $0.50+ he really should be doing so.
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I think it's a calculated gamble. There is still some substantial value in the IPIX pipeline. However, IPIX won't recover from another failed trial.
Leo owns about 8M shares. His wife and children also own a significant number.
The question is does he lock in those millions for himself and his family, or continue chipping away at $500K/year. He is 63 years old now.
If IPIX is not a complete fraud, it's probably about time for Leo to put this nasty drug development business behind us and cash out. Gambling on B-OM Phase 3 solo could cost him and his family everything if it fails.
Given the time lines on the OM phase 2 trial (18 months), the COVID trial, and the fact that COVID is disrupting trials everywhere it would likely take at least a couple years to complete B-OM phase 3. Another year after that to get approval if it is good.
Yes a successful OM interim look is probably the only way we see $1+ again. But after my purchases post-release last week, if I can walk away at $0.40-0.70 I'll be pretty happy all things considered.
Leo would probably like to be sitting on an extra $4-6M and set his kids up with their shares.
Also don't forget our two board of directors have ~1M shares each. They'll probably like them at $600K rather than $70K as well.
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Agreed. I think we're in line for a buyout in the $100M-$300M range. Should happen pretty quickly.
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The problem is, unlike investors, Leo has a sizeable pension, er...I mean salary, being paid to him each year.
If the terms are anything like the B-UP deal I'm not sure he has much incentive to do a deal over collect his salary.
I agree with you that COVID is a dead end. There may be better antiviral targets but they should be partnered out.
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I think it is fundamentally oversold. But I've been wrong for six years running.
However we don't need a successful drug to get out at 5-10x these levels. Just the right hype...it may even come in the form of secondary data points on the COVID trial and/or a partnership.
Would Gilead be interested in running a combo trial with Brilacidin so they can amplify Remdesivir effectiveness?
Leo might be willing to take $30M and a 15% royalty on a COVID inidication at this point. That would send us up to $0.50-$1.00 pretty easily and shore up the balance sheet.
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Probably all up from here if we don't completely run out of money.
Tough to do worse than a market cap of $40M with a phase 3 ready drug along with a number of phase 2B contenders. That's setting aside the potential COVID secondary endpoints/combo treatments and anti-viral preclinical data.
NNVC has existed for 15 years on just pre-clinical anti-viral data.
It currently has a marketcap of $53M...over 20% more than IPIX.
It has had a market cap over $1B in 2008, 2011, 2014 and a pop to $700M in 2017.
In my mind NNVC is undoubtedly a fraud.
The right set of preclinical anti-viral data along with a small phase 2 with the right results could easily bring us back to those heights.
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You continue to mock the greatest CEO of our age.
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Seriously. Does anyone think we cant sell this pipeline for $50M?
Brilacidin is worth $100M on the preclinical antiviral work alone.
The OM phase 2 trial results are probably worth at least $50M as well.
Kevetrin is also likely worth $50M.
Seems way oversold here at $39M if any one of the indications is not a complete fraud.
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Agreed. That is a much larger component of treating longer term viral infections like HIV, Hepatitis, etc.
There are also additional secondary endpoints that coukd make it very synergistic with existing treatments for COVID. There's still nothing great out there. Gilead may get a combo trial on the cheap with us now that we're weak.
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I'm hoping a preclinical deal can be done on some of these viral indications. Or maybe Kevetrin.
You routinely see preclinical deals for 10s of millions upfront.
$300M buyout is looking OK right about now.
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Is secondary data still expected to be released by the end of the month?
Where does that even come from? There was no money to be made flipping after the first hour. What was with the other 90M worth of churn?
Was the company raising money on the bounce back volume? Naked shorts? Such a strange pattern.
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