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The mechanism of action is again immune response. The offered a mechanism but there is only one sure thing the immune system is doing the job if it's the initial virus or the fc following it that cause the immune response is not important. Any drug that keep gbm patients alive is very good news to the patients to society and to pharma companies. Imagine all gbm patients stay alive - the need for drugs will raise . I assume cancer will try to fight back and a combination or another drug is needed. Any new working drug including complete curing is always good news. The mechanism of working drugs will always be immune system that is doing the job I think it's not a competition in cancer drugs world but why to treat all cancer the same with vb111 ? Why to give once in 2 months to thyroid patients and also once in 2 months to gbm after all it's such a different cancer . The decision to stick with once in 2 months for every cancer is like fighting a 7 year old boy with same force u fight mike Tyson. I believe that being aggressive with vb111 in gbm you will get 50% complete responses and 20% durable for couple of years to forever
If vbl was a multi billion company right now I could think of a small chance there won't be buyout but when you are estimated for 17 years since year 2000 as a company that worth around 100 million and when u hear the CEO saying in Hebrew that if a very good offer will come he is selling. I add the very good offer to him saying we think we worth way more than what the market think I think he wanted back then around 5 billion. But now the data shows even better results and kite pharma which aims 5% of cancer was sold for 11b and vb111 is for 95% of cancer maybe vbl CEO became even more greedy so now I would say he wants 5-10 billions but I don't see a scenario this company continue on their own after the ph3 success it simply won't happen the big pharma won't let it happen trust me . There will be a buyout may be a buyout like kite pharma where the company continue to operate as usual although they were bought out. You have to understand the psychology of being a CEO of a small company for many years like a marathon runner he is exhausted mainly by not being appreciated by the market and a huge buyout is in his mind and guess whose mind also ? The big pharma mind they also dream to buy gbm first drug in history . Of course company will tell u we build on success and the plans will show as if no buyout but this is just a show
The place was yesterday. They confirm trial still ongoing. Take a pen and calculate as if trial end nov and see what u get then Dec and see what you get....
Yes . I agree. The attitude is the same and the immune system is involved this is why both should be thought how to be used at healthy for prevention
I consider vb111 a vaccine and not a drug. Anti pdl1 is a drug communicating and intervening with the immune system and therefore have side effects. Vb111 looks like a virus and it acts as a virus and what look like a virus and act as a virus is a virus and a virus is a vaccine. I believe vb111 when it's given to cancer patients it's a vaccine that is being given late. I believe all solid tumors starts as polyp or invisible or visible but undetected pre tumor lesions vb111 is so safe and so specific that it can cause these pre tumor to disappear. If u ask cancer patients who received vb111 they will tell u that one of the side effects is a feeling of like a pain in the tumor area as if there is activity there. I took this patient example from ovarian. Vb111 is so safe so specific and so anti cancer the active way and not passive meaning it just wake up the body to respond that it has to be tested on healthy animals and then human as cancer preventing vaccine
I will give u an example of how ur brain is filling u because u are brain washed. Remember the hole in the ozone ? Do u remember how much they spoke about it ? U were brain washed at that time it has to do with human using certain materials. Do u remember? Everybody knew that because they were brain washed it was a sure thing- wrong. The hope in the ozone has nothing to do with it and it comes and goes - same with avastin. Avastin is useless and cause death
Gbm is highly highly vasculature metastases are also highly vasculature why avastin failed ? It's suppose to work best at these ? The answer is simple u are brain washed by a mechanism that sound very very nice to human common sense starving and all the bullshit doctor wanted to believe but cancer knows and I know it is a lie there is no such thing
https://en.m.wikipedia.org/wiki/Bevacizumab. This is just tip of the iceberg the truth is much worse. Avastin is a joke and the cancer will agree with me. People are not going to agree because u are victim to cheating and brain wash. Look for the word survival in this article and see and this article gave a lot of credit to the devil avastin
I will be clearer avastin doesn't extend over all survival of all cancer types. Not even a one day benefit. All the combination trial that it showed success was luck or not because of avastin
My point is that avastin is not an anti cancer drug. In all solid tumors not only gbm. If u dig deep to the trials of avastin the damage is bigger than the benefit if any benefit and now it's obvious there is no benefit to avastin.
Nothing is sinking. They will recover. Too many important people going to lose. Chip the CEO the doctor the previous management this management . They will come back together or some other solution on the way
Another proof the antiangiogenesis is nonsense - look what happened to patients who didn't react with fever - they lived avastin. So yes at these patients vb111 and avastin worked great together - both of them did nothing.
https://soundcloud.com/levine-media-group/vbl-targets-brain-and-other-cancers-with-novel-immunotherapy
In this interview the CEO even mentioned opposite actions of avastin comparing to vb111. I think if u check avastin real action in tumors not only gbm it's clearly it has nothing to do with vb111. The antiangiogenesis is nonsense . Tumors can easily overcome the blood supply issues
I can't tell but the company can tell And this is why they chose to do it in phase2 . Why not in phase 3 ? Probably fda insisted on soc to everybody. Also here it's obvious at least to me the 2 drugs are completely different and not like a combo with anti pdl1. Vb111 is not working together with avastin - forget about it. Avastin is doing what avastin does which is nothing related to the tumor except some changes in his plan maybe due to killing some nice cancer cells population leaving more aggressive or just because some changes in blood circulation and swelling due to fluid in brain. Vb111 and anti pdl1 yes they may and will work together but not avastin.
The last press release was good news expect green this week
U can compare it to an airplane with 2 engines and limited gas and max speed. If u choose to use the 2 engines from beginning u will fly less distance than starting with one engine and later on add the second engine
Correction "By doing that's I referred to the ph3 that they start it together from beginning
Ph2 started vb111 only and then when progression they add avastin. By doing that u waste the time u got with avastin to stop working...lets assume avastin kill certain cancer cells but lethal population of cancer survive more and more as u progress with avastin and then avastin stop working because now this lethal cancer cells control. In ph2 since u started avastin later the os was better ....u understand my common sense...
Worst case is what u described as 2nd but I believe we will still get better mos in combo not 34 weeks but let's say 45-50 But not 59
Having more long term survivors in combo is great news. The power of vb111 will be the long term survivors . The company already knows that and made it as a motive they repeat again and again. The long term survivors is due to relatively more complete responders. This data match the mechanism of action. For the immune system gbm is just another cancer they know how to deal. Only for us human gbm is a monster but not to the immune system. My theory of how it's going to look like is from William coley work. U have nothing else to compare it 2 except the ph2 results . It's sad that in 2017 everybody is running to car-t while Coley attitude is being done almost only by vbl
Ok = lower than ph2 extraordinary = same or a bit lower it's still extraordinary...
U make it complicated . Let's say there is small group of patients that live very long time with vb111 but it's small group. Median is not average and therefore since it's not average the long term small group of survivors are not going to be showed in the mos because it's a small group at the extreme but when u look at 12 month or more survival u will see them there and the advantage of vb111 will be showed o my there
Of course median can be low and 12 month os high. Look at the numbers 1111112237999. The median os is 2 in this example but if we start at 3 to represent 12 month os the median is 9 or correct me if I m wrong
Haha read my lips they already met the primary endpoint. Median overall survival will be just ok but 12 month overall survival will be extraordinary
Forget all u heard so far about vb-111. Vb-111 is a vaccine and not a drug. It's a vaccine because the job is being done by the immune system. Vb111 just train and wakeup the immune system and make it easier for white blood cells to access the tumor due to the destruction of endothelial cells in tumor area. Vb111 can be cancer protective. They should try it first in animals by inducing tumor like carcinogens exposed rats and see if vb111 has protective properties. It has to be not a once in 2 months treatment but twice a week
My memory tells me but can't recall where I saw it that if 2 treatments of vb111 were done then it counts. The patient u mentioned did have 2 treatments. His wife tried everything possible to help her husband and they moved couple of trials. Avastin side effects made them leave vb111 trial. I m not a fan of avastin
This article also support my vaccine vb111
https://www.ncbi.nlm.nih.gov/pubmed/16490323
Another article
http://www.ener-chi.com/articles/how-infection-can-prevent-and-cure-cancer/
In second article start reading where it sta "why infections save lives"
I read ur posts thanks for digging but something in the story doesn't make sense. This issue with biostage will be resolved. If the tech work it will continue
1 of 2 persons will get cancer at some point in life. You say most people lack the vasculature I say 2 things 1. Let's give it if they react with fever they may have cancer yes ? So it can be a diagnostic test if not immunization . Not a bad thing on it's own. 2. Back to the 1 out of 2 will have cancer I believe the cancer is inside for many years before it become visible and don't be surprised if vb111 will work on healthy people. It's exactly the same as inducing the immune system against bacteria or viruses here don't forget vb111 bring the immune system to the area of the tumor it's not just immune response it's immune response against the tumor accompanied by fever - very strong immunisation. Also you may know vb111 works very good against metastases throughout the body. These are small tumors spreading all over and vb111 cause them disappear so the fact vb111 need vasculature doesn't mean it won't work on what u and me think are healthy people because microscopic endothelial creation may happen in this premature cancer or polyp
Where malaria is common cancer is rare. Cancer may sit inside for years and develop. The common sense behind my idea is that since vb111 is a biological component there is no harm by giving it and the idea of training the immune system is similar to the idea of training ur memory or training your muscles . By injecting vb111 and causing urself fever u may wake up the immune system also against cancer. By the way , every active immunization works like that so why it makes sense against polio but not against cancer ?
Vb-111 to healthy people. Not only vb111 can cure cancer in some patients it can immunized them against cancer for the rest of their life. If u ask me vb111 should be given since safe to healthy people and if fever behind induced it can immunize them against cancer. Of course healthy people doesn't have massive endothelial cells that are dividing but still need to give it to healthy people and check for fever response.
I think the decision to give vb111 every 2 months and not every week is only because they wanted to offer practical solution to cancer patients. I believe the results will be much better if vb111 is given more frequently
How long does it usually take from cutoff date to top line data in phase 3 in cancer ? Any references ?
He starts to talk like me haha
Understanding ADAM F - Adam doesn't really think Dror is a scam. It's all a show. It's like lawyers inside the courthouse or WWF wrestling. When Adam F starts his show ? When there is a spike in stock price and it has to be phase 1 spike (best) but it can also be ph2 spike but better not ph3 spike that there is a good chance it will hold. The reason Adam F leave Dror now is not because back then he thought bad and now he thinks vbl is ok...its only the price action now there is no crazy spike...aldo he likes new attacks. Attacking same company will have less effect because he already scared investors birds that already flew away by his fear stories what's the point to scare the tree again ? The birds are already not there. Once u understand Adam u can save urself all the hate and excitement
Curing cancer with vb111
"Coley emphasized that the induction of fever was the key aspect of his treatment, a strong febrile reaction was the symptom most associated with tumor regression. A retrospective study of the patients with inoperable soft tissue sarcomas treated with Coley's vaccine found a superior 5-year survival in patients whose fevers averaged 38–40°C, compared with those having little or no fever (38°C) during treatment (60% vs. 20%).[22]
The greatest value of Coley's Toxins is evident in the lives of patients who received the therapy. Rather than surviving additional years with cancer, many of these patients lived the rest of their lives without cancer.
"Injections were optimally administered daily or every other day for the first month or two. To avoid immune tolerance to the vaccine, the dosage was gradually increased over time depending on the patient response."
Vb111 is being given once in 2 months while Coley created fever every other day. If we give vb111 twice a week and succeed to induce fever in every treatment we will be able to cure the cancer in many patients. Not only we have to increase the dose gradually we need to use in patients that never reacted with fever or stopped reacting with fever a different virus as vector but with the same property of expressing itself on tumor blood vessels. It's very easy to use many types of viruses so in the protocol u use first one type of virus but then move to more and more types if fever response didn't occur. Of course it's not possible with fda. This kind of treatment is only possible in countries that are more open or almost no regulation because fda will ask a different trial for each virus...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312698/
Iodine not chemo in thyroid and chances to pass ph2 in rgbm is arohnd 10%
I said in the past and this was the main reason I put so much money in vblt. Calculate the chance of these happening together by coincidence...you will get a very low chance. Chance to pass ph2 in thyroid cancer that stopped reacting to kinases and chemo- ~15%. Chances to pass ph2 in platinum resistant ovarian cancers that many patients in trial are also considered refractory - 15%. (Ph2 chance in cancer after ph1 and preclinic were success is 25% but this is average and not the cancers vbl dealt with) now calculate what is the chance all 3 event happened by coincidence.
Amazing new thing I heard from CEO 14 September in his last interview. Vb111 is a blood brain barrier opener. It destroy the blood vessels and by doing that open the BBB. Imagine how many drugs that failed so far can work now in gbm when combined with vb111. Moreover I look now at vb111 as an improved Coley toxin. Dr William coley used his dead bacteria locally on tumor and saved people life and cured many people cancer up to the point they died many years after natural death. Here it's improved because vb111 is being given not locally but it acts locally. Moreover the inflammation here is locally same as with Coley toxin but here the immune cells can reach the tumor easily and destroy it due to BBB being damaged.