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Due to lack of news and massive boredom, I ponder the following:
50% of trial patients were done with complete trial by 7 Jul.
Connected poster said that data was sent up the chain to the CRO as each patient was completed. That would mean 50% of data was in around 7-10 July.
The primary and secondary objectives of the trial weren't based on rocket science, even I could understand them easily. As such, don't see how that many could be in question by trained trial specialists:
Primary Outcome Measure
Time to sustained recovery -Fairly obvious I would expect to trained personnel
Secondary Outcome Measure
All are basically clinical status based on an ordinal scale and the ordinal scale must be fairly obvious to trained personnel.
Thus, for a well-written protocol with a well-defined ordinal scale and trained professional medical people running it this trial shouldn't have been a mental challenge to many.
Now viewing that 60 patients were finished by 7-10 July and the balance by 2 Aug, that means that data has been in the hands of the CRO (at some stage of validation) for about 54 days now. With only 120 patients in the trial, that comes to about 2.22 files per day had to be completed to be done by now.
2.22 files per day and how many expected questionable data variables per file? I can't see more than a couple or so so lets go high and say 3 per file. That means the CRO has to validate about 6.66 questionable data variables PER DAY. Assume they work an 8 hour day, that comes to them being able to "fix" each question in 72 minutes - 1 friggen variable takes 72 minutes to resolve????
Guess only in medicine this is standard
And from these 120 patients (remember only 60 actually get Brilacidin) and the 20-30 data points or so per patient they are supposed to write up a standard EUA pipeline or such that can be 100K-200K PAGES?????
Fast track, pandemic, people dying vs 72 minutes to validate a specific data point. How many people would it take to write anything approaching the size of the EUA pipeline paper???
Yep, bureaucracy at its finest. It's not like their own RBLs or prior clinical trial human safety records for Brilacidin are worth anything. Probably take them a few months to decide if the tides would still be coming in and going out next week.
Anybody else think that the brains behind the Afghanistan evacuation plan (or lack thereof) were then assigned to validate the data from the IPIX trial? Sure smacks of the same amount of gross ineptitude.
Investors (longs) bet on IPIX succeeding. How does one expect them to gain anything before the race is run? Our race begins possibly when Top Line results are published but it could take as long as the full report for the real race to be run as that is when I would expect institutional investors to start coming into the picture.
So if one is a true long, moaning and groaning now is highly questionable.
Traders don't care who wins the race, who wins or loses, they only care on out smarting other traders in continually changing their bets. So for them prior to the race is the big effort.
We will know whether a long is successful or not as the boat will either rise or fall for all of them based on results and that rise/fall should be gigantic.
The traders are a one off as each has their own strategy. Some will undoubtedly make a killing off IPIX (or already have) but IMO a lot more talk a good game than actually made a great trade every time. A winning trader in penny stocks is not the norm.
There is a place for all at the IPIX betting window but it is wise to know just what kind of investor you are.
I am in a quandary as to where big medicine draws the line between established norms for clinical trials, EUA, etc and where they feel they can shave off some time (come on, we know there is a load of pure BS put into these encyclopedic requirements such as 100K-200K for an EUA pathway?, 73 days to check data, who is running these trial sites, a group of monkeys that don't have a clue as to what they are doing?)to move the process along during a pandemic that has basically shut down a lot of the world's commerce and freedom and killed many and greatly injured major organs for many, many more that did not die from Covid. In business, medicine was the only sector that didn't give a damn about either cost or time. They thought both were infinite as since their work was so blessed. Time to get this sector into the real world IMO.
Easy explanation for new eyes on the board as to what they have found in IPIX, especially Brilacidin:
What does Tiger Woods, Secretariat, and Brilacidin have in common?
All are the best in the world at what they do BUT Tiger Woods and Secretariat could always have a bad day and not perform to their expected high level of excellence.
Brilacidin will ALWAYS work at a constant level of excellence.
Its antiviral properties will always kill whatever virus it meets to include ALL coronaviruses and reduce the viral load immediately, its anti-inflammatory properties will always help reduce damage to the lungs, kidneys, head, and other major organs which show prolonged damage with drugs available now, its antibacterial properties will always kill the bacteria that is prevalent in a lot of Covid patients now, its anti-fungal properties will always take care of the black spore fungus, and its immuno-therapeutic properties will always prevent cytokine overload.
There may be some halfway decent additional drugs that become available for Covid, but they pale when compared to the multi-functional properties of Brilacidin.
This seems to good to be true, but remember that Brilacidin is the foundational drug for a NEW ARM OF MEDICINE. It is not just a stop gap proxy for one condition. Its properties make it a spectrum-wide force that will work on so many still undiscovered other body conditions and ailments that it is mind blowing.
Now consider its current cost is .30/share or so. IMO what other investment could you put your money today with a better risk/reward ratio? We cover the board here from very minor players to those that have bet the farm on IPIX. Will find out very soon if our faith is justified but we have a mountain of scientific study backing our belief that Brilacidin will be the wonder drug of the 21st century.
With the expected results, there is no doubt all will be done post haste as with the media blitz I expect after results there is no way anybody will be able to downplay Brilacidin.
As to the competitors whose names end with mab, that stands for monoclonal antibody (mAB).
From what I have read, there are issues with these both in safety and efficacy for anything but mild to moderate symptoms and mainly are used very early in treatment. Suspect as to efficacy if virus already advanced in patient.
Not saying they don't have their place, but I would rather go with a therapeutic that absolutely kills the virus and has no safety issues.
Like our chances with Brilacidin more and more every day.
The SI is a well respected indicator that shows whether a drug should transfer well from in vitro (lab) testing to in vivo (human trial) testing. A score of 426 is remarkably high and should almost guarantee that lab results should transfer to the human trial.
Past clinical trials are just as important as they have PROVED that Brilacidin transfers well from lab to humans, the safety profile has been validated since they have over 400 prior patients in trials that were given Brilacidin with no serious side effects or AEs.
Now add in that Brilacidin was also involved in two major digital investigations of all possible drugs in their expected ability to work against CV and out of many thousands of drugs it was ranked right up at the top.
https://www.globenewswire.com/en/news-release/2021/03/10/2190316/0/en/Innovation-Pharma-s-COVID-19-Drug-Candidate-Brilacidin-Ranked-in-Top-Three-Percent-of-Compounds-Predicted-to-Be-Most-Effective-Against-SARS-CoV-2.html
http://www.ipharminc.com/press-release/2020/4/20/screening-of-11552-compounds-identifies-innovation-pharmaceuticals-brilacidin-as-one-of-the-most-promising-potential-inhibitors-of-the-novel-coronavirus
You can see from the above links why so many longs are livid that it took so long for the govt to finally start throwing some money into investigating Brilacidin (I base this off the work being done by the non-GMU RBL which we think is Rutgers U RBL), the foundational drug of a new arm of medicine, instead of throwing billions at 'repurposed' crap drugs made long ago that weren't even judged to be a possible solution for covid and the resulting talk of "pay for play" by BP and govt agencies doling out the cash.
These reasons form the basis for the complete belief in Brilacidin and why we are so positive that trial results will be spectacular, especially since in the trial patients were given dosings of B for 5 Days. Should have brought the viral load down to near 0.
If anybody on this board came up with the greatest thing since sliced bread, would you sell it to someone without first making it widely known so you could see what others are willing to pay?
Why wouldn't the B platform, or any portion of it as for example the IBD, CV, inflammatory, or whatever separate platforms Leo envisions for B, not be worth a gold mine to any BP? I predict a number of them will be vying quite hard for the B platform.
If it was me, I would be looking for a bidding war.
IMO Brilacidin (plus the value potential of Kevetrin) is worth it to some BP to give IPIX a whole new ballgame of partnership or whatever other deal is arranged by Leo.
We have a game changing drug that the world will be begging for and we should get a deal that recognizes that.
It is a fact with humans that they fear that of which they know not instead of being assured by that they know.
A corporation, no matter how dominant in their field, is always wary of the competition. I worked as a rep for many fine engineered fastener companies and all were paranoid about the competition and made it sound as though they walked on water.
Then they talked about all the weaknesses in their own company and acted surprised they had any business at all, even if they were the world leader in that specific product.
WE KNOW Brilacidin is a completely new arm of medicine with so many anti-XXX properties I get tired naming them, it has shown a remarkably stellar safety profile,it has transferred results wonderfully from in vitro to in vivo, it has shown the ability in all testing to date to handle the entire range of corona viruses,and it is not outrageously costly by any means.
So with what we KNOW we have and that new arms of medicine don't come around every day, that over the last 2 years there has been nothing offered by the BPs who have been given money to come up with something by the truckloads, that the CV variants are getting harder and harder for anything to conquer -
WHY DO WE BLITHER ABOUT REGARDING COMPETITION??
If someone comes up with something of any value, so be it, great for them. But does anybody really see such a COMPLETE PACKAGE coming about within the next month OTHER THAN BRILACIDIN that could possibly even come close to working such as what we will offer??
My suggestion is to not worry now because the threat of a world changing treatment other than Brilacidin is IMO highly unlikely and IPIX will fare quite well even if a competitor came on the market.
The only possible improvement to Brialcidin IMO is a pill or spray delivery system and I believe those issues are being currently addressed behind the scene.
Another week down, how many to go until we finally get the news we have all been waiting years to hear? IMO definitely less than a handful.
If we get good top line results, I would expect some foreign country with a large delta variant problem will issue an EUA for Brilacidin.
Don't know how much Brilacidin IPIX could cough up on a short time line, but getting some patients worldwide getting cured of the Delta variant that were previously in a serious condition would be monumental not only for IPIX shareholders but for mankind.
If that were to happen, I don't see how anything could hold back B being allowed to be used in the USA as the demand and questioning as to the holdup would be enormous.
Bought more stock tody, very happy as every little bit helps, as I can't imagine a better place to park discretionary cash at the current time.
Heading off tonight to hear an old business buddy who is also a professional sax player and his wife (singer) do some jazz and rhythm and blues. Good times all around.
So we get top line results sometime around the end of the month to very early Sept and let's assume as many of us believe that we get excellent results.
Now according to your time line, how long do you think it will take to sign a licensing arrangement, design a P3 protocol, and get an EUA application submitted?
I would assume 2-3 months minimum. More likely end of year at best. Then add another 2-3 months to get P3 actually going as we saw with the current P2 B trial.
And yet NIH director today said delta variant cases would soon top 200,000 per DAY.
That is a lot of people to leave in the lurch when you have data showing that a treatment is already available now to keep them from dying.
Seems that means little to bureaucrats that don't want to stop people dying at the risk of changing their sacred time lines and protocols. As usual, fast track simply BS.
I think govt should immediately give IPIX a $100MM advance or grant to get Brilacidin into mass production immediately and issue an immediate EUA. They wasted tens of billions on worthless BP vac drugs that showed no ability or trial results to be effective, so why would $100MM to a shown capable treatment be considered reckless?
To be honest, I would like to have seen who actually did the trial data for the BP POS drugs that were given immediate OK to proceed as IMO it was the BPs own labs and their results sure didn't match up with reality. I am talking about the seemingly 100% of failed CV drugs in actual trials that tanked after BPs given ungodly amounts to have brought this repurposed crap to the light of day.
As dramatic as I feel our media blitz will be when the muzzle is removed (late Sept or sometime close to that when final results are published?) the entire investing world, and the world population in general, are going to be all over IPIX.
The crap drugs that have come out to date with safety issues, efficacy issues, DNA issues, et al will all look like child's play compared to Brilacidin - safe, effective, wide spectrum, affordable.
If we get the mass institutional investment I think is possible to flood into IPIX and with the likely short position IMO there is in this stock (both legal and naked) the results could be explosive to the upside.
Not saying the above will happen, in fact I do not take the short possibility even into consideration in my planning, but if it does the house will be rockin' and the stock price will be rollin'.
Makes the wait for the trial final results very easy to take knowing that the odds now are staggering IMO for extremely positive results.
That is my reason for hoping IPIX forgoes this PR.
I have a different view regarding what we hear about trial results in the future.
We were informed that the trial was complete as to patients being completely finished, including the 60 day follow-up data.
We were also informed that the data was now being collected, validated, and soon to be analyzed to be able to give top line results soon.
It is my opinion that we will get no further PR until we get top line results. There is no need for publication of each step in the CRO's process of pushing data thru until the final report is published. Each step now is internal functioning of the CRO.
I expect we get a PR for top line and that could be anytime IMO thru the end of the month or possibly right at the start of Sept after the Labor Day holiday and Wall St really gets back to business.
At that time, I believe the media muzzle will still be on IPIX and we will see no institutional investors until the FINAL RESULTS are published which will also be when the media muzzle is removed.
So it is my belief that share price will stay pretty much in the ballpark we see today until top line and then it will jump upon very good results (won't even hazard a guess how much but not that big IMO) and the BIG share price jump happens immediately upon release of the final results due to institutional investors, media blitz, robinhood investors piling into IPIX, and many fence sitters taking the plunge (cannot blame them for waiting until success is guaranteed).
By end of Sept I expect to see many, many smiling faces around here and possibly many, many faces leaving that will be quite welcomed as well.
I remember Govochin to have been a woman, by now probably nearing 100.
Good PR today, what the long's have been waiting for, some idea of when to expect top line results. Now we know we are 2-4 weeks away or so.
But is this news going to send the share price on a magic leap upward?
I say NO!!! This is nothing more than an opportunity for those playing with the SP to run the price up and then shoot it down just as quickly over the next couple of weeks, just as I said to expect when we saw the quick run up to .38 a week or so ago.
No institutional investing will result from this PR as it tells us NOTHING about the results of the trial.
It definitely will not attract enough new retail eyes to sustain a significant price rise (unless the robinhood crowd decides to make IPIX one of their target stocks).
So that leaves the field wide open for the hedge funds and Citadel et al to make hay between now and the actual announcement of the top line results.
Don't get sucked in, there will be games played for the next few weeks without a doubt IMO.
Am I happier today than yesterday? Yes, greatly.
Do I think stock price is immune to drastic pullback? No way.
Let's keep things in perspective. Our day will come, but it is still a few weeks down the road.
They say if one can't understand history they are doomed to failure. This same scenario has played out time and time again for IPIX in the past and will play out again in the same way.
The RBL said last year that Brilacidin appears to be able to work against the Filoviruses and they would be doing more investigatory work on that down the line.
Click this link to show the PR stating same: https://www.globenewswire.com/fr/news-release/2020/06/11/2046799/0/en/Innovation-Pharmaceuticals-Collaborating-with-Regional-Biocontainment-Lab-on-Grant-Application-to-Research-Brilacidin-as-a-Pan-Coronavirus-Therapeutic.html
Here is an excerpt from that article:
The proposed research aims to evaluate Brilacidin as a potential pan-coronavirus therapeutic, for treating SARS-CoV-2, SARS-CoV-1 and MERS-CoV, including extending the current in vitro testing of Brilacidin to in vivo testing. Longer-term objectives include potentially performing additional research to develop Brilacidin as a broad-spectrum antiviral, with possible application beyond coronaviruses, e.g., treating other viruses, such as encephalitic alphaviruses and filoviruses.
The Filoviruses consist of Ebola and Marburg viruses.
Thus Brilacidin again appears to be a prominent drug to fight both Ebola and Marburg.
I haven't heard anything recently but am still under the impression that Brilacidin has yet to meet a virus family that it cannot kill.
RP, can see both
Agree that Brilacidin is much too publicized now to be buried. Good news not just for shareholders but the world.
I hate for posters to bitch and not suggest how they would have changed things so I will give my ideas on how Brilacidin should have been handled (I am assuming I would be given enough power to overcome any payola wall builders protecting BP standing in my way).
Feb '20 Brilacidin started being tested by RBL, data received by computer testing worldwide that it should be among the top 10-15 drugs in having the ability to work against corona viruses. That puts it at the top level of follow-up IMO Government's actual response - sit on their ass because it wasn't a BP drug.
By Spring '20 GMU recognizes Brilacidin killing CV19 in vitro testing to include lung tissue and kidney tissue. This jumps it up to top 5 in testing. BUT WE LEARN IN JUL '21 B IS IN QUEUE TO BE TESTED ON THE DELTA VARIANT - IT HAS NOT EARNED "FRONT OF THE LINE" STATUS YET?????
IMO someone should have been shot for this (literally) in response to the large number of deaths due to the Delta variant while govt sitting on their ass doing nothing. Actually executing someone would have changed the mindset to get things going now or be subject to the same fate.
Jul '20 Clinical trial should have been started without the 6 months or so it took to come up with the protocol and other bullshit to get such a trial going. Medical personnel will throw up their hands in horror at such a thought as this, but their mindset in my opinion is more of "do no harm" than "save as many lives as possible" whatever the costs and these costs may/will put a much fewer lives at risk.
Summer '20 Private trial with no publicity should have been run on 20-40 patients (no double blind) in moderate to severe situation (with patients OK of course) to see if B could improve chances of surviving from the current POS treatment, remsdesivir.
Fall '20 Brilacidin given EUA to be given to those in life threatening situations up to 500 patients to see how it worked. If they died, sorry, but at least it would have saved tens of thousands down the road if it worked and those that died would not have recovered anyway (or had very little chance of surviving). Goes back to my belief you possibly sacrifice willing guinea pigs to provide info that could save many, many times that number down the line from speeding up possible cure.
Jan '21 Worldwide production and distribution of Brilacidin
Can the above have many holes shot in it or Brilacidin to have failed? OF COURSE
But it also would have given us an answer in what will likely be a year earlier than what it will be now. And what is the value of that in terms of lives, personal freedom to again live without the fear of contamination, world economies back to normal, and living back to normal. So would the risk be worth it? IMO YES!!!!
CRO is not creating life, they are simply evaluating data and from what I read in the protocol that data should be pretty straight forward.
Don't need to necessarily hire more people, just get a better computer or a better app to collate the data.
How many medical doctor eyes have to look at this data to come up with a quick top line idea as to whether B works or not?
How hard is it to say
Patient 1 - Did they get better or not? If so, how long did it take for them to get better? Were they any safety issues?
Proceed to Patient 2 - same questions
and so on and so on
And for this it is going to take as some say until the end of the month to get a general top line feel for trial results?
Ridiculous IMO - All goes back to how to one feels pandemic situations should be handled. Medicine obviously doesn't want to change their methods regardless of the urgency of the situation. As a result IMO too many people have needlessly died, world economies have been devastated, and many families have been brought to ruin with lost jobs and restrictions brought about by making sure we didn't alter the methods to get a handle on answers as quick as possible.
They have known about Brilacidin since around Feb 2020. Now it is Aug 2021 and we are still pussyfooting around as though Brilacidin was still considered a potentially deadly cure that must be handled with kid gloves as slowly as possible.
I realize my thinking is not the norm, but it is what it is, and having a joke like Fauci leading the way a disgrace. IMO he is to medicine what Epstein was to finance. What percentage of USA citizens trust Fuaci? Certainly not enough to keep him around IMO.
Strictly an observation:
With all the investigation at 2 RBLs over the last year and a half there is no doubt ALL of the various government/DOD agencies are aware of Brilacidin.
So here we sit waiting for trial result, Brilacidin a FAST TRACK drug, and yet
nobody could come up with $10-20K or so to help the results get analyzed a lot faster by the CRO?
Pandemic, need for speed at all costs, where/don't wear the mask, shut down economies/schools/travel/etc and yet NOT ONE PENNY to help this all important trial result get analyzed faster than normal?
Guess the big foundations and charitable organizations find it wiser to stuff money in politician's pockets?
Sure, that makes sense in today's world. LOL
But in this odd world, come the end of the month we will most likely still be sitting on our hands waiting for results. You just can't make this stuff up.
No money for P3
This article is on the IPIX website under "Updates" and was entered June 7.
Shows that there are MANY in the world aware of antiviral peptides and the benefits they bring to the table against SARS-CoVid 2.
Thank you for bringing it again to the board's attention.
I didn't think that was a good way to get B to the entire body.
Mainly kept B in the mouth and upper throat area.
Did you know that Jonas Salk never patented the polio vaccine and when asked why he didn't he replied "That would be like patenting the sun."
When asked who owned it, he said "The people of the world."
To be honest, IMO this might be the proper route for Brilacidin in use against corona viruses. Pay IPIX a handsome amount (wouldn't have to be that much for each country of the world when they band the amounts together) and let IPIX keep B indications for GI tract, inflammatory issues, etc. and the countries of the world can make as much of it as they need and charge as they see fit (with no further payment to IPIX) so that the world population is safe by B being affordable to all.
We all would like to get rich (and I think we will regardless of route B takes) but Brilacidin as a defender of the world against CV19 and all its variants is something that should be bigger than money.
What I take from posts by people with medical backgrounds regarding the spread of Delta, etc would the only real way to stop the spread of these lethal variants be thru a Brilacidin inhaler/nebulizer/etc so that everyone could carry B with them and take a hit or two as directed to keep the various variants at bay?
Unless you were taking the B spray on a regular basis, one would never know (even if vaccinated) when/if they had become a carrier and could be spreading the variant all around since they show no symptoms.
If that is the case, B would have to be the largest selling drug in history by a wide, wide, wide margin.
Makes all the more important getting B going at a true FAST TRACK speed to try and contain these ever-increasingly dangerous variants.
When the trial results come out and the media muzzle is lifted from IPIX, then the whole nation will become aware of B because IMO it will be front page news and receive top level media coverage.
That's when the volume will start going into the many, many tens of millions per day or more.
If the BPs don't have Brilacidin, they will make sure NOBODY has it and it doesn't come on the market to challenge their much less desirable drugs.
But if a BP does attain the drug, then they will be able to promote it and make sure the right people pass it up the line for commerciality as well.
BPs will know (if they don't already) soon that Brilacidin is the real deal and IMO it scares the living crapola out of them. But for the one that ultimately gets it, it is like finding the golden goose (they just don't want to pay for a golden goose, they would prefer to pay like it is a scrawny chicken).
They could always use the EUA data as to patients that had any AEs to gather a lot of safety data and they pretty much see what percentage of patients recover to evaluate the efficacy side and that should provide enough data to give an OK for commerciality IMO but.....
the medical community will still want their pound of flesh with a full fledged P3 IMO. Guess that provides job security for FDA folks, CRO folks, etc, etc.
Those other 2 can give a much more reasoned reply than me.
My GUESS is the BP would cover the cost of the P3 and a P3 IS NOT essential to an EUA.
The definition of EUA includes the word 'Emergency' so why would it be an EUA if a successful P3 had already been conducted?
I leave that in Leo's hands.
Outright sale now way too early IMO as I believe B becomes bigger than anyone can conceive of today. Would have to have some kind of clause or feature to revalue the company as Brilacidin revenues ramp up.
Royalty OK as IPIX would become the best dividend stock in the world should B revenues soar as I expect them to. If we do have a royalty deal, I expect royalties on a far, far, far greater scale than currently is the norm. Also would expect a nice upfront payment so long term stockholders get some good financial gains now.
Don't think Leo wants to have any long term major functions for IPIX to have to address that would require employees. A little accounting group but nothing more.
I think it is extremely unwise to think only 2 BPs would be interested in acquiring the Brilacidin platform, regardless of cost.
There are plenty of big boys out there and name another drug with the spectrum of indications and Billions of revenue stream potential that Brilacidin possesses.
We are talking a drug platform that EVERY monster BP will covet - why not - since it will be shown to be SAFE and effective, something quite rare today in medicine.
I also think you have to start looking worldwide BPs, not just USA, as there could be hanky panky with USA BPs expecting to get quite a bargain and relying on friends in the right places to make it so. These worldwide big boys will make it quite a bit better financially for us shareholders IMO.
Leo is in the catbird seat. He won't be the one doing the chasing IMO.
I think many on the board misunderstood when Brilacidin was deemed "Fast Track". That just meant that IPIX would have to fast track with a BP to bring the drug to market in a reasonable time frame, if ever.
Now if we renamed it Gilead POS or Pfizer POS we could probably get it OKd for immediate use overnight.
But thank God it is not going to be able to save any lives or help THE WORLD by not bringing forces to bear on it to speed up the process, thus no harm done (at least in the eyes of those regulatory bodies having the say as to moving it forward).
What is one more week, month, quarter of sitting on their butts? That is just life as we know it in the federal bureaucracy.
Ironic post for those that didn't pick up on it earlier.
We wait for data lock and resulting PR saying the trial is officially closed and I have one or two thoughts, not necessarily bitches or kudos but just some things that make me scratch my head:
1. Length of trial - Started in what, early Feb or so and here it took 6 months to get to official closing. In no way is this Fast Tracking, no way in hell.
2. Length of time to make Brilacidin - We keep talking about B being the savior to the world, especially in 3rd world countries, but it seems like it takes FOREVER to make a batch of it. What kind of quantity can they pump out even at full speed via a large manufacturer?
3. Sad that so very few (at least I think we will find out the USA portion of the trial was next to nil)patients came from the USA. Was this strictly due to cost, bureaucratic BS which seems to be the lifeblood of America today, or Leo's way of ensuring our own country wouldn't backdoor Brilacidin for political or payola reasons. Note I am not accusing anyone, just wondering as who among us feel that Covid hasn't been a political football with the losers being the hundreds of thousands of deaths since the start?
4. 25% of trial (30 patients, 15 of whom were treated w/ Brilacidin) were evaluated to see if the dosing could go from 3 to 5 days and this took (from what I heard) 2-3 weeks. That means they had to evaluate 15 patients and it took 14-21 days. How slow do these people work?? And this in the midst of the variants taking major toll of deaths around the world. Scandalous IMO.
5. The time it took to input each patient was IMO, but maybe not those in the medical industry, another scandalous amount of time. I can understand having a clinical trial that is run by the numbers to get all the info needed, but in times of a PANDEMIC why couldn't secret small scale tests (not made known to the public, results not held against the owning drug company, etc) done to get an immediate clue as to whether Brilacdin would work against the various variants running rampant thru the world? Maybe not made known to the CDC/IAH etc unless the RBL found something that worked and seemed to have no negative side effects. Many will not agree with me here, but medicine is hamstrung by their own outdated methods IMO.
6. Now we had 25% of trial patients have no negative AEs because the dosing increase was allowed, 50% of the trial patients were done by early July (including the 60 day phone call) so by the 3rd week of July all but a handful of patients were finalized and I assume safety no problem. So why weren't the final dozen or so patients called as early as allowed by the +/- 10 days written into the protocol? Again, FAST TRACK my ass.
7. Leo's hands were tied as he has to make sure nobody (meaning government agencies) could come after him for ANYTHING and possibly put a kibash on Brilacidin coming to public notice. He is blameless IMO for any and all delays in this trial.
8. So here we sit waiting for the announcement of trial data lock, the expected additional few weeks for top line results, and the further few weeks for final results and all that time people are dying when the answer is sitting, doing nothing, until the bureaucrats get things moving.
9. Luckily, I have had no close friend or family member die of Covid but what if any of us had a very close loved one on the brink of death and we knew the answer was there but not being given FAST TRACK approval like the vaccines were pushed thru? What if one of us has a million shares of IPIX and can't get one dose of B to possibly save a loved one? I shudder to think about that but I feel it is a very real possibility to be happening.
10. All in all, I expect as an investment we all are going to look at IPIX as a great aid to our lives, but to me it has also left a very, very sour taste in my mouth to how things work.
11. Not only the medical issues of getting Brilacidin to market, but understanding the outright THEFT allowed by the government (SEC, FINRA, Fed Reserve, Wall St, etc, etc) in bilking retail investors of Trillions of dollars to cater to hedge funds and big money donors.
I agree with your assessments - the world definitely needs Brilacidin ASAP.
So what does the government do to bring Brilacidin to the forefront of the race for a therapeutic, wouldn't one expect they would push thru advancement of the leading drug as a pan-corona Brilacidin has shown?
NOOOOOOO !!!!!
According to today's PR:
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Related, the Company is in queue for in vitro testing of Brilacidin against the Delta (B.1.67.2) variant, which is showing increased transmissibility regardless of vaccination status according to reports of new CDC data.
Who and what the hell is at the forefront of the queue for testing against the Delta variant? Are there a number of drugs showing the ability to KILL this variant and start to save tens of thousands around the world???
I CERTAINLY DON'T THINK SO.
So why is Brilacidin languishing in the queue??? It isn't as if the Delta variant just arose last week.
IMO the ability for major medical concerns to focus on those treatments/drugs/whatever to END the Covid problem seems to be beyond their grasp!!!!
Does anyone else think since GMU has the experience of testing Brilacidin in vitro against the Washington and Italian (and possibly other variants) Covid virus that testing it against the Delta variant shouldn't be that large a leap to have gotten done over the last 18 months???? I know Delta hasn't been around that long, but they have known how to do the testing for it and putting the virus in a petri dish and hitting it with Brilacidin doesn't shouldn't be that complicated. If it is, borrow $1MM from all those useless tens of billions they gave to POS BPs to push their useless 40 year old do-over drugs.
I seriously believe some leaders of this push for a Covid cure should have been executed for treason against the world or gross ineptitude.
We know it is safe from the raising of dosing from 3 days to 5 after 30% of patients had gone thru active phase of trial so safety should be a given.
SI of 426, past trials showing in vitro results highly predicated in vivo results, Brilacidin actually KILLS the virus so viral load HAS to drop dramatically, and the SOC is currently near 0 (a total waste) so how could efficacy not be pronounced? It should be near 100% with Brilacidin.
How can it fail if no underhanded tricks played?
Completely agree.
You made the following statement in a post today
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"For all anyone knows, Gilead could already have various offers on the table, waiting for PH 2 clinical trial results that might meet or exceed R."
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What results for Brilacidin could possibly not meet or exceed Remsdesivir as they have shown NO positive effect except a day or two shorter hospital stay?
NO reduction of viral load (how could they, it doesn't kill the virus)
NO reduction of mortality
NO benefit except to those with very minor cases
NO acceptance by world health organizations EXCEPT FDA/CDC
Makes one wonder about how all the good things came about for Gilead with their drug being such a POS (IMO).
We have Brilacidin being given by a 5 DAY regimen so IMO we see pretty much total destruction of the viral load with no need for Rems... whatsoever (except maybe they own a few FDA/CDC important members and thus could make any combo drug get accepted big time). I hope IPIX doesn't have to resort to that to get our drug that actually works to the worldwide patients needing it.
Great find. You are a true asset to the board in a major way.
As to the abstract itself, I found very little that had not already been known and PRd regarding Brilacidin. This abstract seemed like a summary rather than new information as to its properties.
I was expecting a great deal more from this abstract so overall I am a bit disappointed.
Disclaimer: I have erred many times as to my first response to many PRs and then later found out I was in error.
My question is do you feel this abstract is that bold and will make Brilacidin a major focal point in the Military Research community or will it be viewed more as a run of the mill abstract and not highlighted by many?
Is GMU the RBL doing the abstract for the DOD abstract? I thought Rutgers RBL was the one doing the research on the really broad spectrum investigation of B, but then I tend to get some facts muddled at times.
Was the ASV abstract kind of a teaser for the DOD abstract since it didn't go that specifically (IMO) into the across the board results for B. Example: anti-inflammatory properties confirmed but just what did this mean and how did they come up with that assertion?
Seems likely GMU should have the full task of exploring B since they started it but maybe it is too big for just one RBL.
Anyway, sure looking to see expanded data and new possibilities for B from the DOD abstract that should be PR'd (again IMO) late in Aug.
Great to know that by Mon we should have the P2 human trial of B for moderate/severe CV19 finished.
Come on Aug, you are welcomed with open arms.
I was at first very disenchanted with the news of the Military Research Conference cancellation, but someone who reads things thru (unlike me) and doesn't go off half-cocked (again like me) showed me where they said that
1. Abstracts would be made available and I take it that is at least for those 2000+ signed up attendees (even though they will be getting their money back for the conference) and I am sure Leo will request a copy of the Brilacidin abstract so that he can then put it out in a PR right around the time of the human trial results.
Thus, the bottom line is that the cancellation of the conference should not hurt IPIX much, if any, IMO.
DOD still knows the results of the RBL investigations (and I think the abstract at the conference will mainly be the Rutgers RBL lab results) and how powerfully they prove that Brilacidin is a wonder drug on being able to kill a broad, broad spectrum of bacteria and viruses. I am hoping the website has a list of their most highly rated abstracts for scientists to review and Brilacidin would be among them.
The cancellation may have wobbled our knees for a second, but we are still standing tall and expected to crush the outcome.
No worries from this end. No worries about the share price either. Who really was going to sell prior to test results except for those that couldn't afford to take that risk and I do feel for them with this pullback in price.