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Since there was positive news today with the patent for Therapeutic Swabs for anti-inflammation using Brilacidin as seemingly the active ingredient in the swab (don't know how use of B via a swab wasn't already a patented use for B by IPIX) one knew that the loser cabal had to once again take the stock price down. Regular as clock work. But a patent is useless for us right now as it will take years probably to bring it to commercialization since it is being introduced into the body via the nose or throat IMO.
Why? She never brought anything to the board but outlandish BS. As fake as the loser cabal that keeps slamming IPIX constantly.
Medicine could get a new antibiotic with a novel MOA that is near perfectly resistant to bacteria gaining resistance to it for only about $30MM or so (cost of a phase III trial); already proven safe. But it seems that is too much for them (either govt or big medicine) so they will let the small number of people keep on dying because a new age antibiotic is not available - all because it is not profitable for BP to develop such a drug.
Makes one scratch your head as to why this drug (B-ABSSI) is left to gather dust on the shelf. Only $30MM or so, not the $1.5B to start from scratch on a new antibiotic w/ a new MOA as the article in my prior post states.
Too bad they don't put humanity back on the front burner.
Attached is a news article link regarding Americans developing resistance to antibiotics
https://www.foxnews.com/health/antibiotic-resistance-rise-doctor-warns-enormous-problem
We aren't on the same page on this subject.
Leo has done quite well running IPIX to the tune of millions - $400K/yr adds up
Hope one day investors at least get their money back.
I agree that BeaMed will start gathering revenue next year for the Scorpion Laser System but I believe it will take another 2or 3 years to build the revenue up sufficiently (say $75MM+) so they get a big share price for the IPO.
If they put out the IPO while revenues are just starting to ramp up the share price will be minimal IMO.
We will see. I personally wouldn't mind a small IPO share price if it will keep IPIX afloat.
AI will absolutely dwarf the Industrial Age as to advancing human progress; it will be the focus of allowing humans to become interstellar travelers IMO. But as is the current case of hackers/criminals/terrorist oriented countries to corrupt it by always seeming to be one step ahead of the good uses for the technology IMO it will lead to the termination of humans on earth. Too many folks interested in making the perfect robot soldier and weapons for it not to be used that way.
The point of this post, though,is wondering how long it will take medicine to start taking advantage of the potential IA holds to rapidly, insanely rapidly, to bring new drugs and devices to the public. As of now the medical community seems to use computer knowledge very little as Brilacidin has been ranked among the top drugs for potential use against virus, bacteria, and fungal problems but there appears to be next to no advancement in any area once the testing gets beyond simple petri dish investigations.
AI should be able to shorten the decade long time frame to bring a new drug to market to a much, much shorter span of time IMO but then will the powers to be allow such a threat to their power bases and income? I have no faith in the powers to be to allow such advancement.
I hope BeaMed is using AI extensively to synchronize their laser,software, imaging functions to attain the maximum level of precise cell elimination possible
I strongly agree since IPIX should be running out of money by the end of the year as I understand their cash position. If no decent deal is signed prior to that, the means for IPIX to secure further capital is such that they would most likely have to wipe out current investors IMO to be able to sell the vast majority of the company to the new investor(s). This has been my main worry all along. BeaMed I agree will be a wonderful investment for IPIX but it will not be bringing in any funds for a few years yet as before they issue an IPO they would have to build up revenues and that takes some time even with wonderful new technology.
I feel IPIX should immediately consider giving up ALL of Oral Mucositis to secure some millions to be able to carry the company forward until we see some significant progress in both BeaMed and S. American fungal treatments. I give Alpha Sigma next to no hope in providing any help and IBD seems a long shot since they still have to modify the pill a bit per what was given recently in some filing. If someone would give us any half decent (just not horrendous) terms for some portion of IBD I would look seriously into that as well. Do anything to keep the company sputtering along and bring in some funds and that might make the wolves at the door looking for the demise of the company to realize they aren't going to be successful.
It does make for a situation that leaves most IPIX shareholders IMO scratching our heads.
So how can the medical community have completely shut out Brilacidin with its many top level findings of working excellently against most to all bacteria, viruses, and fungi??
One pharma company must realize that there is enough meat on the bone with Brilacidin for both them and IPIX to flourish once the drug gets put to use against the many areas of medicine in which it could help.
Hard for me to believe the medical community is this clueless; must be some other reason and to me it is that they fear what Brilacidin could do to quite a host of Big Pharma popular drugs.
This investment requires liberal use of the ignore button. IPIX will succeed at some point; my worry is whether any of us current owners will still have a stake (as opposed to new investors) when that time comes. Unless Leo signs some decent deal, he has no way to raise funds at the current stock price that doesn't dilute shares MASSIVELY.
Sometimes known as “germ warfare,” biological weapons involve the use of toxins or infectious agents that are biological in origin. This can include bacteria, viruses, or fungi. These agents are used to incapacitate or kill humans, animals, or plants as part of a war effort.
Wonder where the military could find an agent that would work against, bacteria, viruses, and fungi in their quest to defeat 'germ warfare'?
Maybe one that also has a different MOA (method of action) so that these bugs couldn't develop resistance to it?
I think we all know the answer but it seems to date - along with all other areas of the government - not a dollar can be found to develop Brilacidin for this necessary defensive measure for our military members. Disgraceful.
I don't see why Covid would have had any significant reason for AS not to be able to develop a simple gel, foam, or other type application method in a timely matter. I have thought that B would not travel throughout the whole body but the application would make it only for the tissues in the last few feet of the colon so it should have been a very easy P2 to develop and have excellent results.
As such, I have thought IPIX were idiots not to put some time line on AS to perform or lose their rights to the postsigmoid (sp?) treatment. I could be wrong on this but still feel AS has been next to useless in moving B (IBD) forward.
My main interest now is for S. America to really push for a B application as an anti-fungal. It is in both our interests for them to light some fire in this rocket that is not going to happen thru the FDA IMO.
Once it works in S.America maybe someone in the US medical power scheme will stop whoever or whatever agency that has currently put a lid on pursuing B in a timely manner.
What do we have now, about 3 months before the results of the antiviral study in regards to about 100 viruses can be put out? And the ludicrous, insane reason given for the delay was for some damn student wanted it used for their thesis or some such BS?
Pretty easy to see I am still mighty pissed off over the whole IPIX state of affairs. Leo and the FDA are the two main reasons for me being so upset.
AlphaSigma IMO has been a total waste - all they had to do was make a gel/foam/etc for application thru the anus and in what, 5 years or so?, they haven't moved forward one iota. F'ing losers IMO.
I have already said I don't believe BeaMed comes up ready for first users until next year even with the best of intentions to move forward as soon as possible.
That leaves a partnership and Leo can't say squat until one is completed. As such, not expecting much in the way of news this summer or even fall.
This patent news is good but makes me wonder how much of our money we burned doing it as we are staying afloat by inches financially as it is. All of the investigational work is being done outside our house so not sure just how much they are keeping Leo abreast of news. I still think S America and fungal advancement will come about quicker than anything thru the USA. My disdain for the FDA, INH, etc is well known and I don't see them changing.
Even better a mid to big pharma other than Merck to form a new anti fungal cocktail and basically take over ALL the business Merck has from CAS. This same thinking could then be used for combining B with other BP patented drugs that are nearing end of patent life. Might light a fire under their ass to get something new going that includes Brilacidin as the new and improved model.
IMO testing of the BeaMed system would be a few months (or more) of digital modeling prior to even testing on animals. Also seems that this type of endeavor would be great for AI assistance
The best line IMO from the 5 June BeaMed PR was the following
"The completion of these probes allows for comprehensive integration tests, involving the unique MRI compatible fiber optics, an MRI interface software suite, special algorithms to simplify damage estimation, and custom insertion tools, planned to commence in late June 2023
"
These guys don't let any grass grow under their feet!!
Won't give any estimation when human testing can commence but it sure doesn't look like it will be that far down the road. I am hoping by the end of the year but that is just a WAG..
I certainly don't see this PR as worthless.
I believe IPIX will keep advancement PRs for Brilacidin and BeaMed separate.
In the Pipeline section of the IPIX website it shows Brilacidin at the Phase 3 stage for ABSSI and OM and Phase 2 stage for Covid and IBD yet only in pre-clinical for Fungal.
Why does B have to go thru a P1 for Fungal when it has already shown over and over it is safe for humans?
To me this is pure BS for in Fungal applications it will only be used stand alone or with current authorized FDA drugs.
I am not expecting any rollout of BeaMed until first half of 2024, Can't remember where that time estimate came from so take it with a grain of salt. All in all, this investment and the medical/medical devises market seems to take far longer than one would expect to move things forward.
Assume that some BP (other than Merck) wants to develop a new cocktail that uses both Brilacidin + Caspofungin (Merck drug). How can they do that if they do not have the approval of IPIX and Merck? I assume they can't just use our products and decide for themselves how much of the revenue they give to each party, they can't make both drugs on their own as there are patents, so how would somebody other than Merck be able to come up with a new drug using both these products? Even Merck couldn't come up with such a cocktail if they don't have IPIX OK on the table IMO or else they would screw us to the wall and give us next to nothing. Say someone did come up with such a drug and it then proves to be toxic for some reason, do they assume all risk since neither IPIX nor Merck gave them an OK for such a product?
I am not being antagonistic here, I am hoping someone can show me a path that would allow such a cocktail to come about should Merck have no interest in moving forward on such a drug. Say they can make a new drug, how much does IPIX get and how much does Merck get and how much is left for the new BP making the new drug?
Two items that bother me::
Merck currently has customers for life as their product, Caspofungin, doesn't kill the fungi but only prevents it from growing. What would motivate them to combine it with Brilacidin to Kill the fungi and thus end the need for further treatment once the fungi has been eradicated?
Would like to see IPIX spin off BeaMed into a separate company so that if IPIX goes belly up the current shareholders still have the investment of BM still available which should at the worst provide for full return of investment.
This 1 application, Aspergillus fumigatus, for Brilacidin + the Merck product Caspofungin, involves over 300 million cases a year per the UFRN article posted here today (based on the recent article that was published in Nature Communications) but then the same article says that it affects up to 5 million people per year.
It states in the paper that Caspofungin can stop the fungi from growing but cannot kill the fungi; add Brilacidin and it kills the fungi as well, in both the lungs (pulmonary aspergillosis) and the eyes (fungal keratitis) and it kills at a remarkably high degree (as in over 90%).
To add a significant additive benefit, again per the article, in addition to Aspergillus fumigatus, brilacidin alone or in combination with caspofungin kills Cryptococcus (causing cryptococcosis), Candida albicans (causing candidiasis) and even the recently discovered super fungus, Candida auris. Cryptococcus is a fungus that is naturally resistant to caspofungin, but when it faces it together with brilacidin, it becomes sensitive.
The above gives me hope but what really is different from prior bullshit articles from US sources as to investigating Brilacidin is the following excerpt from the article
“The process is long, but it is important to put the name of Brazil on the science map, to show that we, from universities in the Northeast, can contribute with value to research and publish articles in high impact journals such as those of the Nature group,” reinforces the professor.
Brazil is anxious to move B forward as they have a financial impetus to move it forward w/ the agreement between IPIX and U of SP in them getting a cut of any revenues due to their research and bringing a product to market, they have a national pride impetus to get B on the world scene ASAP, and they have quite a number of skilled researchers already working hard on the project.
Time is obviously still a major factor but IMO we finally have somebody on OUR SIDE as to moving B forward expeditiously. I do have a modicum of hope now for Brilacidin seeing the light of the day some day in the next few years. Maybe I will be able to retire sometime before I die after the next 3 or 4 years.
The fact that the BPs haven't already started further investigations into Brilacidin and anti-fungal applications shows more about their ineptness or bottom line worries than it does the efficacy of Brilacidin IMO. The fact that not even one has indicated they will investigate further shows they work in collusion to keep new treatments out of their spheres of dominance.
IMO BP worries about their income #1, #2, and #3 and their patients somewhere much further down the line. They could see a cure coming out of when is B added to their current treatments and that in turn would hurt their bottom line due to treatments ending fairly quickly or actually curing the problem outright - thus, B would not be good for them. I know some will call me a nutcase for this thinking but I have absolutely NO BELIEF that any drug company works for the good of the patients, they work only for the good of their investors.
I hope our new connection in S America thru University of Sao Paulo quickly advances B in the anti-fungal field via investigations as a synthesizer or a stand alone treatment. Maybe they are allowed to run trials on voluntary patients as opposed to the monstrously expensive and time consuming clinical trials required by the FDA..
Main questions to me is how fast can they set up some sort of human trial where B is used as a synthesizer (can it be applied via IV while the approved treatment is also applied via whatever system they use to get their drug into the patient) or a stand alone informal trial.
Main problem could be money; on one hand getting enough to be able to bring some sort of trial to life or possibly the BPs paying off the handful of people doing this needed work in S. America to make sure it never sees the light of day. Again, I don't put this past the BPs in protecting their bottom line.
Thanks, I hadn't looked into the 10Q. Going to be tough though if some things don't come together ovrr the next year. Here's to hoping they do.
BeaMed is going to be good for IPIX, no questions asked. But what is the total revenues we can expect BM to bring in yearly? I would think a hundred million would be great and anything beyond that quite unexpected but then I am not sure of the market for a new level of imaging/surgical device. This would be quite a feat but nowhere close to where B could/should have put us with the multi-billion dollar markets it could address.
I would feel a lot better if they could suspend everything in regard to IPIX that would cost anything until we start seeing some revenues come in from BM. If they don't, and I thought it was said somewhere that it costs $1-2MM / yr just to keep the doors open for a stock of any type, that IPIX will fold before BM could help us. Hope that is greatly exaggerated because if it is true IPIX IMO will not be able to keep the doors open until that time unless they acquire new funding and if that comes about it would pretty much wipe out us current stockholders.
OM is small potatoes. Goldman is expert in fungal medical applications and they are huge. There we have over a million dying each year and a million per year going blind from corneal keratitis alone. Let B attempt to help those patients as most of them are in S. America.
Could he not know about this program? Hard to believe but one never knows.
My only thought is that these are BPs that are getting the go-ahead and not start-ups. Drives me crazy. OM a perfect example- even if it fails what harm could it do to not allow it to even be tried?.
Look what the FAA did when they gave Boeing the right to test everything themselves without govt oversight on the 737 Max and Boeing turned around and didn't do squat as to holding themselves to a safety level one would expect in a new plane. Same thing with BPs and new drugs with the FDA. Big money leads to big allowances and one knows that BP likely has many political and government employees in their hip pockets.
The biggest 800 lb gorilla in IT today is obviously Artificial Intelligence (AI). For all the wondrously good it will/could do for mankind, IMO it is too powerful and capable of generating too much money if used for evil /criminal uses for that to become its dominant use. End result IMO is that machines will wipe out humanity one day especially since it is beyond possibility that the rogue nations of the world (China, Korea, Iran, Russia, etc) will not use it to perfect weapons and machines that will be able to kill on a scale unheard of today. Too many kooks with high IT/AI knowledge for some not to go off the deep end and try to build their own forces patterned after comic book type heroes and villains of today..
But prior to that AI should be right up BeaMed's alley IMO to perfect their technology. If all BM lasers can continually reprogram themselves thru AI to better be able to image, interpret the images, and refine the laser to wipe out the tumors/lesions they find the technology would improve at a speed never seen before. If all the lasers using BM could feed back their refinements so that all other users become instantly aware of upgrades that would be even better.
But as it is today, I don't see BM having the assets to put AI into their projected laser. I also am disappointed that the product requires a special laser as the current builder of them (in the same building as BM and Shina Systems in Israel) only employs 50 or less so the ability to ramp up production should the early users find the technology quite advantageous not possible. I have posted before that I feel the IPO of BM (when IPIX will actually be able to garner some revenues or have their share price rise substantially) is dependent on rising revenues and with the limited production currently possible that may take a minimum of a couple of years to be able to demand a decent IPO price.
I have lost faith in the US government thru the military, FDA, BARDA, etc to move B forward so that only leaves some BP to offer a decent partnership for some part of the B platform and the way that BP typically works (screw the startup to the wall) I am not overly expectant that is going to occur. Something could come about via fungals and S. America involvement but that again is a long shot IMO. Keeping it real and not expecting much for quite a long time. We have the goods, but IMO we don't have the means to advance B. Sure hope something happens to prove me wrong but until such an event occurs, I don't see the importance of 10Q, 10K, etc as everything is on hold until a deal is made and I don't have the belief in Leo any longer that he can bring that about.
There is no current investment in this stock and that should remain the case until the shorts finally bankrupt IPIX. Something has always been off regarding this company for a couple of doctors could put up a couple of million each and have one of the best drugs there has ever been (if B truly as good as we believe) and with all the wealth in the world that should have happened IMO. As it is now, to get the money to allow IPIX to limp along until BM takes hold I believe all current stockholders (except Leo) would lose all our investment.
The state the US is in today is that they have built up such a bureaucracy in all matters that to get anything done takes years and years, wastes untold time and money, and so we are always working from a behind-the-times situation.
I just read where a long term aviation expert said that the air traffic control system in the US is about the second worst in the world; why? Because the time it takes to identify, understand, and react to the problem is so lengthy that technology keeps passing us by.
I see the exact same situation in medicine. Safety is important, but it is so highly regarded tthat the problems sweep right on past the solutions available today. Such is the case for Brilacidin across many sectors IMO.
I see nothing on the horizon for IPIX until Q4 at the earliest. 'Til then, I won't get worried about a quiet zone around the board.
Never ending story!! Trouble is no further chapters ever get written.
In your opinion does IPIX have a better chance / faster development of getting Brilacidin approved as an anti-fungal agent being tested on human patients as in clinical trials or Compassionate Use thru the workings of U of Sao Paulo in S. America or thru the workings of organizations in the USA?
If 1MM+ people are going blind in jungle areas due to corneal keratitis caused by fungi is there a chance some S. American countries would allow it to be used for testing VERY QUICKLY on those patients that would most likely go blind today since nothing seems to be currently working?
The main fear I have for IPIX is time - time we don't have as we don't have the funding to keep IPIX going after 2023 unless something else occurs to raise funds. This new fungal initiative looks promising but if it is anywhere like what we have seen w/ bacterial and viral infections in the USA it won't come about soon enough to save current investors.
Your input is about the highest degree of knowledge-based opinion we have IMO so how you feel regarding this matter means quite a lot to me.
IMO a complete waste of money which IPIX does not have.
Beating a dead horse as medicine is not all that interested in being able to combat superbugs as this problem is now about 50 years old (?) and yet no advancement has been made for over 2 decades against them..
The above statements I base on the fact that BARDA, NIH, Big Pharma, and all other so-called organizations out to protect humanity from drastic medical issues has failed to allot even $1 over the last decade or more to alleviating this problem after the P2 clinical trial of B against Daptomyacin results were made known.
Regardless of B showing a completely novel approach to killing the bacteria and possessing the ability to almost guarantee that bacteria cannot develop a defense against it, it has sat on the wall vegetating, nobody the least bit interested in curing something that affects a major worldwide body of patients.
Somehow saving lives just doesn't fit into the picture of funding priorities.
I agree it should have been done but Leo hasn't been good about publicizing negative news.
We are in quite a pickle.
Gnashing of teeth over the move of IPIX to the Pink Sheets; my two cents on the matter:
People seem to not realize the extreme financial distress of the company. Unless Leo signs some decent partnership by the end of the year the money will pretty much run out and if that happens the raising of additional funds will pretty much gut the investment of all current stockholders as the new source of money will take everything but the kitchen sink to invest a decent sum. This is not a charade, IPIX will go under if the current financial picture doesn't change - regardless of how great is the science of Brilacidin or BeaMed!!
Leo knows the severity of the problem and by going to the pink sheets he cut some costs by eliminating the regular financial documents that must be filed to keep a company on the OTC. For this I applaud him for we all know that there are no revenues and not much comes out of these reports to spur investment by normal companies or individuals. So that is the positive side of going Pink.
The negative side is that we are now at the mercy of Leo for information and he has shown himself a leader that could care less about keeping the investors of the company up to date with information. To his side, though, everything currently going on is all preliminary deal making that he can't post publicly anyways. Further investigation of B for whatever reason is of no matter until a deal happens so whether we know about it or not doesn't seem that important.
I thus don't see anything adding to the risk of IPIX by going Pink. What I do feels adds to the risk in a major, major way is that he hasn't cut his own salary to a level commensurate with the work he his doing - which is certainly not anywhere close to $30K+ PER MONTH. This action IMO is why I put my investment in IPIX as so much of a pipe dream right now. He probably sits on the board of BeaMed or some such deal so he is going to do well whatever IPIX does, but those of us that only have IPIX are left out hanging to dry. This scenario would explain why IPIX was able to invest in BeaMed in the first place. I have lost faith in Leo specifically for this matter.
No need to follow IPIX any longer on message boards or daily checking of the stock because if something happens (as in a deal of some sort) it will be sent via an email from the company. Until then, I assume the company is just spinning in circles as it has for many years now.
What article is being referenced? I must have the poster on ignore as I don't have any post showing the article w/ B426 or DeGrado in it.
Major outbreak of Marburg virus in Gunieau and Tanzania per the attached article:
https://www.foxnews.com/health/cdc-warns-marburg-virus-deadly-africa-outbreak
B had shown effectiveness in earlier testing and was one of the 20 viruses tested that were completed last spring but results can't be released until Oct or Nov of this year.
Maybe this will spur a lot of emergency HUMAN testing of B on Marburg. It is in the same family of viruses as Ebola.
If people are dying and there is no treatment currently available, what is there to lose in trying anything and everything?
Have decided not to do a recap on Brilacidin as most everyone here is pretty conversant on the drug.
Enough to say it is a broad spectrum candidate for bacteria, viruses, inflammation, and fungal conditions. What other drug can say that?
It has been under investigation by various entities now for 6 or 7 years and yet still more investigations necessary whereas a BP can get a new vaccine on the market after testing on 6 monkeys or mice, have poor results, and still get the OK for humans across the world. What's up with that???
Right now it is stagnant and will stay that way until we get a partnership. Even great news by some source will not move this drug forward unless somebody comes in with bucks to allow it to progress to commercialization.
Can Leo make something happen? Hasn't to date but one never knows.