Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Since people keep asking. Here’s my intel.
I masked most of their identities just so they don’t get treated like a daily drama episode like Tony is on these forums. Honestly these updates on Tony makes me wonder who’s compassionate and cares and who’s just a vulture.
[url=https://ibb.co/DgmHTT3][/url]
[url=https://ibb.co/xCPYGX4][/url]
[url=https://ibb.co/DW2HdN6][/url]
[url=https://ibb.co/SyWfCxJ][/url]
[url=https://ibb.co/KbYmdS5][/url]
If I didn’t have word from individuals inside of Houston Methodist, word from medical professions that are in connection from people inside of Houston Methodist, I would have cashed in my chips already and played the flip and short game. I’m back to 100% portfolio exposure on this one again after plying quick flip on other tickers. But, there’s always that possibility. Relief has 0 income or assets passed RLF-100. So if they get approved, we are all going to do well for ourselves. If not. Well. 99% of us will be bagholders because there will be 0 incentives for buyers to trade this stock. So assess your risk tolerance accordingly
I’m always ocd about wearing a mask and limiting my time and conversations with others. Fingers crossed. The joys of working at a college.
Hurry up and get approved already!
Just found out I was exposed at work to a positive case.
Aviptadil. The next “penicillin”?
If these claims are true, the potential for what this drug can do is immeasurable.
What Does VIP Help?
The question should be what VIP doesn’t help. Here’s a CIRS related list.
ADH/MSH/VIP – these three hormones move together. When one falls the other two follow and visa versa. MSH is another master controlling hormone that among other functions is critical to having healthy gut and healthy endorphin levels. Low endorphin levels means everything just hurts more along with a lack in the pleasurable feeling of being in love – with someone or some activity. Unfortunately, MSH is not available as the FDA banned MSH replacement drugs – for no good reason as they had been used in the past with no ill effect. On the other hand, ADH is linked to feeling thirsty all the time along with all the unhealthy impacts of being dehydrated. ADH can be difficult to correct in people with CIRS and is often skipped especially when patients don’t’ complain about thirst or frequent urination. Without VIP, MSH and ADH/Osmolality would be difficult to correct in many with CIRS.
Androgens – step 5 in Dr. Shoemaker’s protocol works to try to correct the male hormones androgen and testosterone. CIRS folks will have lower levels. Unfortunately, the standard protocol of supplementing with DHEA at 25 mg taken three times a day and HCG (human chorionic gonadotropin) injections of 125 mg per week (or sublingually) doesn’t always work. Although tempting, going to your doctor for testosterone supplementation is not recommended for CIRS patients as the supplemental testosterone is often just converted to the female hormones estrone and estradiol. This is because low VIP causes the enzyme that converts male hormones to female hormones (aromatase) to become overactive. In addition, the body may have a difficult time later on when testosterone therapy is stopped. When testosterone levels don’t correct with DHEA and HCG, VIP can be tried at 4 sprays per day for 30 days.
TGF beta1 – if you read TGF beta 1 – Mold – Turmeric, you know that people with CIRS have high levels of inflammation that is indicated by high levels of the blood marker TGF beta1. As discussed in that article, Dr. Shoemaker, uses Losartan (Cozaar – blood pressure pill) when TGF beta 1 is high especially if CD4+CD25 combo cell levels are less than 17. However, the blood pressure on some folks with CIRS can drop too low. I mentioned trying curcumin to help bring down inflammation associated with high TGF beta 1. Happily, for those that are struggling to bring down TGF beta1, VIP comes to the rescue.
C4a/MMP9/MASP2 – similar to TGF beta1, C4a and MMP9 are two additional CIRS inflammatory markers that are down-regulated with the use of VIP. Furthermore, given that C4a is driven up by MASP2, it should be no surprise that this enzyme is also lowered.
Vitamin D – in Alternative Mold Therapies – Vitamin D, I discuss the fact that vitamin D is frequently low in folks suffering from CIRS. Typically, the 25-hydroxy vitamin D level is very high and the 125-hydroxy level is very low. VIP fixes this.
VEGF – inflammatory cytokines choke off blood vessels. Unfortunately, Vascular Endothelial Growth Factor (VEGF) responsible for stimulating new blood vessels is often low in CIRS. When VEGF is low, the body struggles to make new blood vessels to offset the restricted blood flow. When VEGF is low or TGF-beta 1 is high, people will not be getting enough oxygen into their bodies to support the complete conversion of glycogen (sugar) into ATP energy molecules. Instead of getting 38 ATP energy units for every unit of glycogen, people suffering from capillary hypoperfusion only make 2 ATP units of energy. In other words, 95% of the energy that was stored in the form of glycogen is wasted. If you don’t have oxygen, you can’t make energy. VIP raises VEGF levels. In addition, constricted blood vessels can cause Pulmonary Artery Hypertension (PAH). PAH reduces blood flow due to high blood pressure in the lungs that makes the right side of the heart work harder. VIP reduces pulmonary artery pressure resulting in improved blood flow during exercise.
PASP – VIP brings PASP (pulmonary artery systolic pressure) during exercise back to normal. In CIRS, PASP is measured by looking for tricuspid regurgitation in the heart – reverse blood flow in the heart. When VIP is low, heart arterial pressure will be too low; the body will compensate by increasing heart rate – tachycardia. VIP therapy will raise pulmonary artery systolic pressure during exercise within days. Tachycardia, palpitations, and shortness of breath may be due to low VIP. According to Dr. Nathan, mold can cause Postural Orthostatic Tachycardia Syndrome (POTS) and certainly lower systolic pressure due to low VIP could be a cause. Interestingly, Dr. Shoemaker has not found high blood pressure as measured with a cuff in those with CIRS.
Brain – eventually I want to write an article on how CIRS causes many parts of the brain to swell. One of the consequences of this is that other areas shrink (atrophy). The caudate nucleus near the center of the brain that is responsible for voluntary movement, learning, memory, sleep and social behavior is one of those areas in the brain that gets smaller. It takes at least 4 months (6 months is typical), but VIP can fix the caudate. According to Dr. Ackerley, VIP has a lot of anti-inflammatory effects on the brain.
VIP improves brain function, blood pressure, enhances innate and adaptive immune function, and changes the inflammatory expression of genes.
Multiple Chemical Sensitivity (MCS) correlates to low VIP so when VIP is used, chemical sensitivity markedly decreases.
VIP fixes gingival disease and receding gums common in CIRS.
VIP has the potential to dramatically help some of the worst CIRS patients. In addition, VIP can lengthen the time a susceptible person can be in a water-damaged building and reduce the symptoms they experience after re-exposure.
http://biotoxinjourney.com/vip/
I’m hedging my bets on approval. Or at least an EUA.
I’ve probably logged over a hundred hours just finding first, second and third hand reports. Doctors, nurses, friends, colleagues, patients. If I wasn’t 100% certain I would have pulled my chips from the table instead of anteing up every chance I get.
Is this treatment 90% effective like everyone claims? More like 60-70%. But when compared to Remdesivir at only 35%? We have the winning hand.
The suspense as thousands of investors frantically hit the refresh button on their favorite otc news source. You can feel the tension in the air right now. As if, you woke up from a long slumber and don’t know if it’s Christmas or not.
Correct me if I’m wrong. But relief has minimal or 0 production and distribution capacity. They just own the patent and intellectual rights to the drug. So call it a partnership, call it a licensing agreement. I’m fairly certain that’s why in the GEM contract, they had to leverage the patent for the drug as collateral. That’s their main and only asset. And that’s why some have referred to this as a “virtual company” even back to the day they were still called mondo, if you look at the ED medication, it was produced out of house.
It’s not the size of the team that matters!
Did everyone sleep on the previous Javitt interview with Dr.Yo? Or is the day to day tick chasing just etch-a-sketched everyone’s mind?
In the interview. Javitt said he was going to announce 2 major partnerships. 1 for distribution and 1 with the #1 supplier of inhaled medications. I think it’s safe to say that company would be announced with the launch of the.... wait for it.... Inhaled Aviptadil clinical trial start? Maybe? Possibly? Sort of a connection there? No okay maybe they are just going to partner with Pfizer and mix this with viagra and call it a day....
I’m talking about the inhaled trial. They will with high probability update it to include the partners name, before the official PR hits the wire.
IMO today will be the highest risk day to not hold shares overnight. We are waiting on news of the beginning of the inhaled trial. But we are also waiting on news for the inhaled drug partnership. Keep those 2 items in your mind today when you are thinking about buying or selling EOD.
But that’s up to you guys and gals to asses your risk tolerance. After hours would be the perfect time to make that announcement. I could be wrong. But the timeline is there for this to be in the realm of possibility. Tomorrow could be a brand new day where we finally break into dollar land. The inhaled trial is already priced into today’s shares. But what is not priced in is the unknown variable of who we are partnering with. Keep a close eye on the clinical trial website and proceed with caution.
Welcome to the madhouse JulieA. I see curiosity and a slow day on our other ticker has brought you here!
Small gap on open. Let’s see if the new found devote flippers made a wise call yesterday or just lost leverage.
I seen this on a Facebook investors page for aviptadil. Any thoughts here on this?
Look at the Conditions section.
Critical COVID-19 With Respiratory Failure
Acute Respiratory Distress Syndrome (ARDS)
Corona Virus Infection
Acute Lung Injury
They have ARDS and Acute lung injury separated from COVID in the wording. So is this going to be approved for non covid related ARDS and acute lung injury?
[url=https://ibb.co/59NJb6m][/url]
It is definitely one that takes commitment.
I was thinking this stock is more like that relationship where you just so desperately want it to be acknowledge, so you try to learn everything about it, show it your interested in growing together, even keep throwing money at it in hopes it takes notice. But no matter what, it will always be distant, ignoring you and secretly be more interested in that one guy that has more money than you....
And with some of my earnings if this ever produces, I think a nice long therapy session is in order for deep rooted traumacies.
Okay not a rick roll video this time.
Javitt posted this to Neurorx Facebook today. Is he trying to throw a hint? Why would they share a 2 month old video?
WE GOT NEWS!
Flippers just lost bigly!
Well nice to dream. But looks like we’re walking back down to .55 this week again.
Let’s just hope hedge funds sees a 110+!billion dollar valuation from a single drug. If it does hit 50 you better have a sell in ASAP because it will fall faster than it climes there. Just imo.
COV2 also a virus of the heart.
Curious, would aviptadil help in this situation also?
Initially #SARSCoV2 was considered a respiratory virus.
— Eric Topol (@EricTopol) August 27, 2020
New @GladstoneInst findings in both iPSC-> heart cells & autopsy indicate it's a heart virus, w/ a distinct pattern:
—myofibrillar fragmentation
—loss of nuclear DNA
—"complete dissolution of the contractile machinery"
1/ pic.twitter.com/zhhoErqfVl
Good to see no shares being dumped. Seems like everyone is holding strong though. I think what is going to really make this ticker pop is once they get the stop sign lifted from the OTC markets after they come current with filings. Should be happening soon also.
Was hoping RLFTF would have made bigger moves so I could have liquidated and scooped up more shares. If we’re expecting moves EOW there might be still a chance.
I think you have it backwards good sir. I so far 90% of the market movement has been decided by the Swiss. They were the early investors on this and I’m pretty sure they have more shares than us.
We’re investors not shareholders. If dilution is a big issue. Probably want to move on to some blue chips. We’re funding the trials now at these prices so we can reap the rewards when they are done. Simple as that. This isn’t like AAPL where they are already established.
Internet outages reported across all trading platforms and major p2p providers like zoom.
https://downdetector.com/
[url=https://ibb.co/VHxppFg][/url]
[url=https://ibb.co/s6yybr9][/url]
Only made money if you sold. The rest is unrealized according to Uncle Sam. And unrealized gains are as about as safe as a snowman in July.
It seems they are carefully and precisely navigating the waters for what ever reason on this. All of their discoveries, findings and press releases have been there. But tailored in a way in which they never seem to break first on the same minuscule news site. The only way I discovered this stock was from the NY post article. But since then it’s been a game of hopscotch of PR. Even their pre-prints go from on site to another on where they are released. The latest 21 patient report? It was posted on the ssrn site and not preprints.com and when it did make it to preprints, the article was amended over the 6 patient trial instead of having its own new entry. I’ve yet to see any of these articles hit PR news wire or any official news listings that would hit major brokerages like my E*Trade. There is 0 news for the entire month on there.
So the O/S wasn’t hammered as bad as we thought.
Note: GEM Global Yield Fund LLC SCS ("GGYF"), a major shareholder in RELIEF THERAPEUTICS Holding SA ("Relief"), entered into an Option Agreement with Yves Sagot, CSO of Relief, on August 31, 2017, for 66,666,667 shares of Relief. As the term of the Options had an expiration date of August 31, 2020, GGYF exercised its Options in the manner provided for in the Option Agreement and those shares have been transferred to GGYF's account.
Gem only drew down 66m options instead of 666m so total o/s was only increased to 2,534,168,581 instead of going over 3 billion as we all had anticipated and though after the previous filings.
My statement about the petition.
I am actively in the process of seeking out new leadership for the petition and place it in the hands of people who have a closer connection to the events unfolding. The petition which was started in good faith, has gained more traction and momentum than I anticipated. There is small rumblings about the morality of having this lead by a current investor. Which shortsightedly I did not realize at the time, this would become an issue. I created it out of spontaneity in realization that this could be a way to help affected families to know there is an option to help a loved one. To also hopefully get an audience of policy makers to see the current treatments available and keep the drug from being swept under the rug by large pharmaceutical companies.
To avoid the mission of this petition from being tarnished, I will formally and completely separate myself from it. To not only avoid creating a negative light on our goal, but to also avoid giving Samivir the appearance of being just another snake oil treatment.
I would like to thank everyone here for helping get the word out and helping raise awareness for the drug.
We all know this has a low probability of swaying the opinion of the FDA. But what it does is provides hope, information and spreads the knowledge and awareness of this drugs existence. I lost my dad to cancer when I was in my early 20s. He was given 3 months to live on diagnosis. My mom and I got him 21 months extra time. When all doctors gave up and standard of care was exhausted, it was up to me to research, find the best hospitals and most promising clinical trials while my mom advocated, planned hospital visits, hotel stays, flights, buses etc.
There was one thing I learned. Nobody is going to advocate and search for a treatment for you or a family member. If it wasn’t for random strangers on message boards and forums helping guide decisions with what did and did not work for their loved ones, my dad would have missed my college graduation. He would have missed seeing the ultrasound of his unborn granddaughter. He would have missed birthdays, vacations, extra time with the family.
Yes I do have a financial stake in this company and yes I would like to see this do well. I have quite a few comorbidities. If I get covid, chances are not in my favor. I would love to be able to leave behind a paid off house for my family and a financial cushion.
But I have also personally reached out to complete strangers asking for help on social media, giving them all the info they need to give to their doctors to try and get into these trials. Quite a few got approved, but because of the BS they are put on waiting lists. A man lost his wife recently waiting. A wife lost her husband a few days before that waiting. Another daughter is frantically trying to get her mom this treatment at the new “trial site” and have been denied. I’ve been in their shoes and a little piece of me inside died with those strangers. I know the hopeless feeling. I tried helping them like I helped my dad and they got so close yet couldn’t get the intervention they needed.
We should be creeping up on clinical trials starting. September should be a good month for us!
“The AstraZeneca vaccine uses an engineered cold virus to attack COVID-19. Bush called the vaccine "new science."
Oh hell to the nah. I will pass on that one.
People are out there protesting GMO’s and here we are in the middle of a pandemic that might have been lab created, and the best option.... is to go get injected with a man made cold virus (probably a coronavirus) and they want to skip phase 3 trials all together on this one. Let’s hope Samivir works on COVID-21 when this thing gets rammed through all safeguards
https://amp.palmbeachpost.com/amp/5642163002?__twitter_impression=true
After much fanfare about its launch, the vaccine trial for COVID-19 in Palm Beach County is on pause because of "political pressure," its principal investigator says.
Researchers said at a news conference Aug. 17 that they had received the vaccine and were ready to administer it to the first 10 test subjects.
But the chief investigator for the vaccine trial confirmed to The Palm Beach Post on Thursday that the trial is on pause because of a question by the U.S. Food and Drug Administration on whether a European trial is good enough to start manufacturing and distributing the vaccine.
The news of the trial's pause comes as Vice President Mike Pence told the nation at the Republican National Convention on Wednesday night that a vaccine would be available by the end of the year.
More: Coronavirus: Palm Beach County picked as COVID-19 vaccine trial site
Dr. Larry Bush, the vaccine trial's primary principal investigator, said the FDA is looking at whether the trial can be bypassed altogether and the vaccine approved using “emergency utilization access." The European trial found the vaccine to be effective.
Emergency utilization access is used by the FDA for compassionate use with patients with a life-threatening condition.
The problem, Bush said, the FDA usually approves a vaccine using results only from U.S. trials — not those conducted in other countries.
The renowned infectious disease specialist describes himself as apolitical but said "there is a group of people" in the high echelons of the federal government pushing to short-circuit U.S. vaccine trials on COVID-19.
"What is holding all this up is the political pressure," he said. "I think having a pandemic in an election year is a problem. Either way, people use that as a point that they are right and the other side is wrong."
He said that if President Donald Trump's FDA does approve emergency access utilization for the vaccine then the true effectiveness of it may never be known and a bad precedent will be set for vaccine trials going forward.
He said getting trial subjects for a vaccine already approved will prove especially difficult.
Bush noted, however, that emergency utilization access can be a good thing.
He agreed with the FDA's recent approval for the use of blood plasma from patients who have recovered from COVID-19 as a treatment for the ill even though a study found it ineffective.
The reason it was ineffective was patients with COVID-19 weren't getting it soon enough because of bureaucratic red tape, Bush said. The FDA's decision streamlined the process for physicians so patients can receive blood plasma faster.
Researchers in Palm Beach County had hoped to be able to enroll hundreds of test subjects by October with results rolling in by the next month.
"We can go any day at 24-hour green light notice," said Bush, adding that he hoped the FDA's question will create only a "slight pause" in the trial.
More: Vice President at RNC says COVID-19 vaccine will be available by end of the year
The vaccine was developed by AstraZeneca and scientists at England’s Oxford University. One among many vaccines currently in Phase 3 trials, the AstraZeneca vaccine seemed especially hopeful because it not only created antibodies to block the virus but it also created T cells that could destroy it.
CBS News reported this week that the pharmaceutical giant had the capacity to make 3 billion doses when the vaccine is ready and is on a "massive manufacturing drive" even before governmental approval.
The Post learned about a pause in the Palm Beach County study when a reader reached out to JEM Research Institute, conducting the study on the campus of JFK Medical Center, to see when she was scheduled to get the vaccine as a registered test subject. She was told no appointments were being made.
Dr. James Goldenberg, the founder of JEM Research Institute, referred all questions about the pause in the trial to AstraZeneca. The pharmaceutical company did not return a phone call seeking comment.
The pause in the vaccine trial comes after JEM Research Institute opened up its testing site to the media and to Palm Beach County Mayor Dave Kerner.
Bush has said that Palm Beach County was chosen because it was a hot spot for the novel coronavirus.
The AstraZeneca vaccine uses an engineered cold virus to attack COVID-19. Bush called the vaccine "new science."
Posted an updated on the petition.
PETITION UPDATE
First update!
EditDelete
Dohn John
United States
AUG 30, 2020 —
I am grateful for the global support and attention this has received so far and would like to thank everyone for sharing this!
We are all well aware that this drug still needs to be verified by placebo controlled studies and is still in clinical trial phases. Every day over 5,000 people are dying because of this terrible disease, over 1,100 alone in the United States, 1,000 in India, 800 in Brazil as of Friday’s numbers. Still globally there is a severe lack of expedient and efficient testing to correctly diagnose and treat these patients. We may not know the scope of the virus for many years to come.
With so few effective treatments available and wealthy nations buying up global supplies of all possible interventions it is imperative that all promising breakthroughs be investigated and funded accordingly. Compared to Remdesivir, which costs thousands of dollars to patients and takes months to synthesize. VIP (Vasoactive Intestinal Polypeptide) is relatively inexpensive and quick to produce.
While I know this petition probably will have minimal bearing on the approval process I had created it for 3 main reasons.
First, most people have never heard of this drug and are unaware of its existence. This is to help them know there is options in the pipeline! This with Leronlimab have shown early promise in the battle against COVID-19. Aviptadil is currently available under the SAMICARE compassionate use access trial program. More details, including patient consent and doctor authorization paperwork can be found here: https://clinicaltrials.gov/ct2/show/NCT04453839?term=Aviptadil&draw=2&rank=3 I would like to note though, that only a few hospitals have access to this drug currently.
Secondly, we must keep the conversation going! This drug is threatening many major players in the anti-inflammatory market. This drug has so much potential beyond COVID-19 and is set to disrupt many drug markets. It is hard to believe with millions of dollars of lobbyist money floating around Washington and other governments isn’t trying to keep this suppressed.
Third and finally, I still have faith that some politicians have the common persons interest in mind and will set politics aside to help get this to more hospitals within their borders. Families who have exhausted all other options should be allowed to have access of this on a right to try basis. So please, reach out to your local law makers and politicians with this petition and show your interest!
Thank you all again and keep up the good work!
Additional links:
Patient consent form for compassionate use. : https://clinicaltrials.gov/ProvidedDocs/39/NCT04453839/Prot_ICF_000.pdf
Preprint of one of the first patients treated : https://www.preprints.org/manuscript/202007.0178/v1/download
Latest Preprint of the first 21 compassionate care patients : https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3665228
Best thing to do is share it on social media to get more exposure.