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NKGN
Keep an eye on this news today
CEO will release data about cancer tumor trial
Dr. Song’s presentation will cover a variety of important topics, including industry challenges in manufacturing autologous NK cells at scale, which has been successfully overcome by NKGen’s next-gen CMC manufacturing process in its production of its autologous NK cell therapy product, SNK01. In addition, Dr. Song will discuss the results from SNK01 treatment in combination with either immune checkpoint inhibitors in patients with advanced solid tumors, or, in combination with Erbitux in tyrosine kinase inhibitor-resistant non-small cell lung cance
SANTA ANA, Calif., May 16, 2024 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) (“NKGen” or the “Company”), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous, allogeneic and CAR-NK natural killer (“NK”) cell therapeutics, today announced that Paul Y. Song, MD, Chairman and Chief Executive Officer of NKGen, will present highlights of the Company’s cryopreserved, autologous, non-genetically modified NK cell therapy product, SNK01, which has demonstrated enhanced cytotoxicity and activating receptor expression for the treatment of neurodegenerative diseases and solid tumors, at the 5th International Cell & Gene Therapy China Summit & Exhibition (CGCS) to be held in Nanjing, China, from May 22–24, 2024.
CGCS will showcase exclusive new data in the several areas, including solid tumor treatment, off-the-shelf therapy, innovative cell therapy, AAV gene therapy, affordability of CGT, global cooperation, RNA therapeutics, and CGT commercialization. CGCS 2024 anticipates over 6,000 global attendees, more than 200 exhibitors, greater than 200 world-class speakers from large pharma, innovative biotech, and academia.
NKGen Presentation Details:
Title: Autologous NK Cell Therapy
Session: A: Cell Therapy Focus
Section: A2: Original Innovation in Cell Therapy – Universal and Solid Tumor Treatment
Date and Time: May 23, 2024, at 4:30 PM CST (China Standard Time) UTC/GMT +8
Dr. Song’s presentation will cover a variety of important topics, including industry challenges in manufacturing autologous NK cells at scale, which has been successfully overcome by NKGen’s next-gen CMC manufacturing process in its production of its autologous NK cell therapy product, SNK01. In addition, Dr. Song will discuss the results from SNK01 treatment in combination with either immune checkpoint inhibitors in patients with advanced solid tumors, or, in combination with Erbitux in tyrosine kinase inhibitor-resistant non-small cell lung cancer.
The presentation will also include the scientific rationale and supporting data behind the use of SNK01 in neurodegenerative disease specifically emphasizing the ability of SNK01 to improve levels of amyloid beta, tau, and alpha-synuclein proteins as well as GFAP, NfL, and YKL-40, which are elevated in numerous neurodegenerative diseases including Alzheimer’s, Parkinson’s, Lewy Body Dementia, Frontotemporal Dementia, Multisystem Atrophy, and Progressive Supranuclear Palsy alluding to the potential use of SNK01 to treat these diseases or as a possible prevention in high risk asymptomatic patients with elevated biomarkers.
NKGN
Huge news just out this morning
100% pop coming
NKGen Biotech Announces Upcoming Publication at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
Mentioned: NKGN
GlobeNewswireApril 24, 2024
SANTA ANA, Calif., April 24, 2024 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) ("NKGen" or the "Company"), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous, allogeneic and CAR-NK natural killer ("NK") cell therapeutics, today announced an online publication at the upcoming 2024 American Society of Clinical Oncology (ASCO) Annual Meeting to be held virtually and at the McCormick Place Convention Center in Chicago, Illinois from May 31-June 4, 2024.
ePublication Details:
Title: Interim analysis of a phase I study using cryopreserved non-genetically modified allogeneic natural killer cells with enhanced cytotoxicity (SNK02) in patients with advanced solid tumors without lymphodepletion
Authors: Victoria Chua, Sant Chawla, Erlinda Gordon, William Feske, Lucia Hui, Hank Lee, Yoonmi Kang, Juan Mata, Katia Betito, Paul Chang, Paul Song
NKGN
rebounding nice
Huge P1 interim result for Cancer tumor due this month and P2 interim data for moderate Alzheimer due next month
$10 price target until June
Be patient here
Huge P1 interim data for cancer tumor due this month and humongous P2 interim for moderate Alzheimer due next month
1000% explosion coming
NKGN
Exploding on huge news
$3 price target today
NKGen Biotech Announces FDA Clearance of Investigational New Drug (IND) Application for SNK01 NK Cell Therapy in Parkinson's Disease
Mentioned: NKGN
GlobeNewswireApril 29, 2024
NKGen advances its neurodegenerative disease program with FDA IND clearance for its Phase 1/2a SNK01 Clinical Trial in patients with Parkinson's disease.
The Company expects to initiate a Phase 1 clinical trial in PD in 2H 2024.
SANTA ANA, Calif., April 29, 2024 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) ("NKGen" or the "Company"), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous, allogeneic and CAR-NK natural killer ("NK") cell therapeutics, today announced that the U.S. Food and Drug Administration ("FDA") has cleared the Company's Investigational New Drug ("IND") application for SNK01 NK cell therapy for the treatment of Parkinson's disease ("PD"). SNK01 is an autologous, nongenetically modified NK cell product that has enhanced cytotoxicity and activating receptor expression, potentially addressing a novel approach to tackling Parkinson's disease.
The FDA IND clearance enables NKGen to initiate a Phase 1/2a clinical trial evaluating the safety, tolerability, and exploratory efficacy of SNK01 in patients with PD. The trial is designed to enroll up to 30 patients (20 receiving SNK01 and 10 receiving placebo). NKGen expects to begin the trial, with the first patient dosed, in the second half of 2024.
"The IND clearance marks a significant milestone as we advance our pipeline of NK cell therapy in neurodegenerative diseases," said Paul Y. Song, MD, Chairman and Chief Executive Officer of NKGen. "This is our second IND approval for SNK01 within the past several months and underscores our focused dedication towards developing safe and effective treatments that target both protein deposition and neuroinflammation for patients with neurodegenerative diseases such as Alzheimer's and Parkinson's. We are excited to start our first clinical trial in PD as there currently is a high unmet medical need in this indication."
Dr. Song further commented, "Given the encouraging outcomes regarding the reduction in neuroinflammation observed in our Phase 1 Alzheimer's trials, we are optimistic about the potential benefits that may emerge in our Parkinson's trial. Although these two neurodegenerative diseases differ, both share a neuroinflammatory component, which has led to our hypothesis that SNK01 may be beneficial in both indications. While directly inhibiting neuroinflammation, whether as an independent approach or in conjunction with other interventions, may not address the etiology, it can potentially decrease the production of factors that contribute to neurotoxicity, thereby hopefully leading to clinical improvements."
NKGN
Huge news just out
NKGen Biotech Presents Updated NK Cell Therapy Data for Neurodegenerative Disease at the 12th Annual Alzheimer's & Parkinson's Drug Development Summit
Mentioned: NKGN
GlobeNewswireApril 25, 2024
In vitro studies with SNK01 have shown a direct ability to phagocytose and digest amyloid and alpha-synuclein proteins while also secreting immunoregulatory cytokines and identifying and eliminating autoreactive T cells that contribute to neuroinflammation.
SNK01 autologous NK cell therapy demonstrated a positive effect on improving cerebral spinal fluid ("CSF") and plasma levels of Tau, amyloid, and alpha-synuclein proteins in Alzheimer's patients suggesting a potential larger application in the treatment of other neurodegenerative diseases associated with these proteins.
90% of patients enrolled in the proof-of-concept Phase 1 Alzheimer's trial had improved or stable cognitive function at week 11 using the composite ADCOMS score.
SNK01 was also found to reduce neuroinflammation, showing improved levels of Glial Fibrillary Acid Protein (GFAP) in most patients, Neurofilament-light (NfL), Growth/Differentiation Factor-15 (GDF15), and Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2), suggesting a potential preventative clinical application for SNK01.
NKGen submitted an IND for SNK01 in Parkinson's disease ("PD") in Q1 2024 and anticipates to begin enrollment for its Phase 2 trial in advanced Alzheimer's disease ("AD") in Q2 2024.
SANTA ANA, Calif., April 25, 2024 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) ("NKGen" or the "Company"), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous, allogeneic and CAR-NK natural killer ("NK") cell therapeutics, today announced the details disclosed in today's presentation by Paul Y. Song, MD, Chairman and Chief Executive Officer of NKGen, entitled "Evaluating Adoptive Cellular Immunotherapy for Neurodegeneration with Autologous SNK01", in which the Company shared additional information on the scientific rationale, preclinical and clinical data to date on the use of SNK01 enhanced NK cell therapy in patients with advanced AD and PD.
The presentation highlighted preclinical data showing the ability of SNK01 to phagocytose and digest both amyloid and alpha-synuclein proteins, the ability to secrete cytokines, which are able to inactivate inflammatory cells, as well as the ability to reduce autoreactive T cells, which have been implicated as a significant contributor to neuroinflammation and damage. In addition, compassionate use case studies of patients with advanced Alzheimer's disease and Parkinson's disease treated with SNK01 were presented as well as an update from the Company's Phase 1 Alzheimer's trial.
In the Phase 1 AD trial, SNK01 was administered intravenously ("IV") every three weeks for a total of four treatments using a 3+3 dose escalation design (1, 2, and 4 x 109 cells) in patients with either mild, moderate, or severe AD (Median MMSE of 14). Cognitive assessments and extensive CSF/plasma biomarker analyses were performed at baseline and at 1 and 12 weeks after the final dose. The primary endpoint was safety and secondary endpoints included changes in cognitive assessments and biomarker levels.
SNK01 was found to reduce and/or improve levels of pTau, amyloid AB42/40, and alpha-synuclein protein biomarkers suggesting that it could have utility far beyond Alzheimer's. 90% of patients enrolled in the proof-of-concept Phase 1 had improved or stable cognitive function at week 11 using the composite ADCOMS score.
In the presentation, Dr. Song commented, "While elevated amyloid AB42/40 is primarily implicated in Alzheimer's, alpha-synuclein protein levels have been noted in several other neurodegenerative diseases as well, including Parkinson's, Lewy Body Dementia, Multiple System Atrophy, and Pure Autonomic Failure. In addition, elevated Tau levels have been associated with Frontotemporal Dementia, Progressive Supranuclear Palsy, and Corticobasal Degeneration. We believe the ability of SNK01 to have a positive impact on all three proteins suggests that it could have clinical utility for numerous neurodegenerative diseases well beyond just Alzheimer's and Parkinson's. In addition, based on the recent publication by Guo, et al.1, which examined over 50,000 adults from the UK Biobank and found that GFAP, NfL, GDF15 and LTBP2 were consistently associated most with "incident all-cause dementia", biobank specimens from the Phase 1 trial were reassessed to explore the effect of SNK01 on each of these biomarkers."
Dr. Song further added, "In our dose escalation trial where the majority of the patients received suboptimal dosing and only four total treatments, we saw SNK01 was still able to reduce levels of all four biomarkers in at least 30% of all patients, suggesting that this could one day be potentially used as a safe preventative treatment for high-risk asymptomatic patients with elevated biomarkers especially with a higher dose. We are very impressed with the safety of SNK01 and ease of administration and its ability to cross the blood brain barrier. As more biomarker and clinical data emerge, we believe the potential applications of SNK01 will only increase."
Presentation Highlights:
SNK01 was shown to phagocytose and ingest amyloid and alpha-synuclein levels in vitro.
SNK01 was found to produce immunoregulatory cytokines in vitro.
SNK01 was found to reduce autoreactive T cells in vitro.
SNK01, given via a simple IV administration, appears to cross the blood brain barrier to improve AB42/40, Tau, and alpha-synuclein protein levels in CSF.
Despite a median MMSE score of 14, and 70% of patients treated at relatively low doses of SNK01, at one-week post-treatment (week 11):
50-70% of all enrolled patients in the trial had either stable or improved CDR-SB, ADAS-Cog and/or MMSE scores including one patient whose MMSE score improved from 14 to 23.
90% had either stable or improved ADCOMS scores.
60% of patients had improvements in GFAP and 30% of patients had improvements in NfL, GDF15, and LTBP2 after only four doses.
SNK01 appears safe and well tolerated, with no treatment-related adverse events observed; and the data suggest SNK01 may have potential clinical activity in AD. A larger Phase 2 placebo-controlled AD trial with a higher dosing and longer duration will begin to enroll in Q2 2024.
Rationale for use of SNK01 in Parkinson's was discussed along with the clinical trial plan to initiate a Phase 1 PD trial in 2H 2024.
A copy of the presentation is available on the Scientific Publications page of the Company's website at https://nkgenbiotech.com/.
1Guo Y et al. Plasma proteomic profiles predict future dementia in healthy adults. Nature Aging. 2024;4:247-260. https://doi.org/10.1038/s43587-023-00565-0.
NKGN
SNK01 was found to reduce and/or improve levels of pTau, amyloid AB42/40, and alpha-synuclein protein biomarkers suggesting that it could have utility far beyond Alzheimer's. 90% of patients enrolled in the proof-of-concept Phase 1 had improved or stable cognitive function at week 11 using the composite ADCOMS score.
NKGN
big data presentation for Alzheimer’s and Pakinson today and interim P1 result in May
This is $300 mil mktcap stock trading at $40 mil mktcap
Monster running higher
Trial result for Alzheimer and Pakinson and cancer tumor coming out
This is billion dollar stock
NKGN
just broke $2 resistance
Keep going up higher
NKGN
exploding over $2 now
This is worth $200 mil mktcap at least
$10 price target
Exploding huge over $3
NKGN
exploding again
Huge news for another P1 interim data for cancer tumor presentation
Many catalysts on the way
This is billion dollar stock indeed
Great result for many trials keep on coming
CEO has planned systematic trial readout in a row
Another huge P2 interim result for Alzheimer is due in June as well
Pps will keep on going up to fair market valuation soon
NKGN
Keep an eye on this explosive ticker
another huge catalyst for P1 interim result due in May as per the news AH
Another catalyst in May
Huge interim result of P1 trial for cancer tumor
Huge news just out
NKGen Biotech Announces Upcoming Publication at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
Mentioned: NKGN
GlobeNewswireApril 24, 2024
SANTA ANA, Calif., April 24, 2024 (GLOBE NEWSWIRE) -- NKGen Biotech, Inc. (Nasdaq: NKGN) ("NKGen" or the "Company"), a clinical-stage biotechnology company focused on the development and commercialization of innovative autologous, allogeneic and CAR-NK natural killer ("NK") cell therapeutics, today announced an online publication at the upcoming 2024 American Society of Clinical Oncology (ASCO) Annual Meeting to be held virtually and at the McCormick Place Convention Center in Chicago, Illinois from May 31-June 4, 2024.
ePublication Details:
Title: Interim analysis of a phase I study using cryopreserved non-genetically modified allogeneic natural killer cells with enhanced cytotoxicity (SNK02) in patients with advanced solid tumors without lymphodepletion
Authors: Victoria Chua, Sant Chawla, Erlinda Gordon, William Feske, Lucia Hui, Hank Lee, Yoonmi Kang, Juan Mata, Katia Betito, Paul Chang, Paul Song
Abstract Number: e14515
Session Type: Publication Only
Session Title: Developmental Therapeutics - Immunotherapy
A copy of the ePublication will be available on the Scientific Publications page of the Company's website at https://nkgenbiotech.com/.
NKGN
Another huge news out
NKGN
moving up again
Huge Alzheimer and Pakinson presentation tmrw
Still under $40 mil mktcap for P2 Alzheimer and Pakinson stock
Long way to go until $1 billion mktcap just like SAVA
NKGN
What a monster
Humongous data presentation tmrw
$6 price target this week
Still $120 mil mktcap for Alzheimer’s stock
No shares available for shorts
Looks like $3 is on the way tmrw
NKGN
exploding now
Almost $2
NKGN
pps keep going up in anticipation of huge presentation
$2 break out imminent
Going for $2 today and $3 tmrw and $5 on Thursday
So much undervalued
Do not forget this was trading $3-$4 a month ago
Thus presentation is biggest annual meeting for Alzheimer and Pakinson
NKGN
SAVA. Alzheimer stock trading at $880 mil mktcap now
What will happen here upon astounding data presentation of Alzheimer and Pakinson on Thursday
This Pps is a gift
1000% explosion coming this week
SAVA. Alzheimer stock trading at $880 mil mktcap now
What will happen here upon astounding data presentation of Alzheimer and Pakinson on Thursday
This Pps is a gift
1000% explosion coming this week
NKGN
grab all you can now
Big boys buying up cheap shares before astounding data result of Alzheimer and Pakinson worth $60 billion world wide
Still $50 mktcap and going for $200 mil mktcap at min
Good luck all
This is what happens when the float is locked up by big boys
This bio co is worth more than $200 mil with promising P1 result of Alzheimer
150 big pharmaceutical international companies will line up to make a deal after astounding data presentation this Thursday
The low float was locked up now
Going for $3 today
Still low mktcap based on astounding p1 result of Alzheimer
NKGN
Keep going up
Huge data presentation for Alzheimer’s and Pakinson on Thursday
This is going for $200 mil mktcap which is Pps $8-$10
Good luck
NKGN
keep an eye on this monster
8 mil float is locked up now
Humongous data for Alzheimer’s and Pakinson on 12 th annual summit among 150 big pharmaceutical companies
Insiders holds majority shares here
8 mil float was locked up now
Shares Outstanding 5 22.81M
Implied Shares Outstanding 6 22.39M
Float 8.05M
% Held by Insiders 1 57.71%
% Held by Institutions 1 17.11%
AH or Tmrw for sure
Big boys are accumulating now