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MackG... agree in part...
Here Today...spot on again!
(and post/er to which you responded is once again...incorrect)
Rdunn...YOUR RECENT ERRONIOUS POSTS: (corrected)
YOUR POST #1.
williamssc...you are absolutely correct... (Rdunn, incorrect)
If wanted...likely they can produce 100 Million doses (less complicated to formulate) at a fraction of the cost of, and likely infinitely more effective than Remdesivir
Upon first positive CT POC indications, under the Defense Procurement Act: "The federal government can, ...use it to jump ahead of other clients or issue loans so a company can buy all of the supplies it needs to complete the government’s order by a specific date. A rarely used authority of the law also allows the administration to control the distribution of a company’s products and determine where such materials go."
BINGO! J&J and PFE are drug production monsters in U.S. and can be ordered to produce Brilacidin before anything else..."...the Defense Production Act has been used to place hundreds of thousands of orders by President Trump and his administration to ensure the procurement of vital equipment..."
Where will "Overseas" Trials be conducted?
Look at the dynamics and who is likely engaged in IPIX's decision where CT should occur...
Regarding prior CT of Brilacidin, before IPIX's technology purchase, Dr DeGrado (now Scientific Advisor to IPIX), who is a member of the National Academy of Science, the National Academy of Inventors, the American Academy of Arts and Sciences, and a fellow of the American Association for the Advancement of Science, ... a past President of the Protein Society and was the scientific founder of PolyMedix, which discovered brilacidin...also served as President, Chief Executive Officer and Director of PolyMedix, Inc.
Where did PolyMedix conduct Brilacidin Clinical Trials for "successful" ABSSSI indication? RUSSIA Federation...11 sites in Russia and 5 sites in Ukraine
Brilacidin ... ABSSSI Human Clinical Trials...
Sponsors and Collaborators
PolyMedix, Inc. (IP developer from whom IPIX acquired Brilacidin).
Locations
Canada, Ontario
Hamilton, Ontario, Canada, L8N 4A6
Canada, Quebec
Chicoutimi, Quebec, Canada, G7H 5H6
Greenfield Park, Quebec, Canada, J4V 2H1
Sherbrooke, Quebec, Canada, J1H 5N4
Trois-Rivieres, Quebec, Canada, G8Z 3R9
Canada
Quebec, Canada, G1V 4X7
Russian Federation
11 Sites
Multiple, Russian Federation
Ukraine
5 Sites
Multiple, Ukraine
Sponsors and Collaborators
PolyMedix, Inc. ...
With the highly charged partisan politics of in FDA of not wanting to give Trump any positive news...IMO conducting Brilacidin CT in Russia would be a brilliant decision by Leo and DeGrado...less bureaucratic, with "warp speed" like turnaround possible...
IMO we should be looking for CT to start in Russia by first week in Dec...(if not before)...informal indications within 7 days thereafter...definitive results reported by Certifying 3rd parties (Outside Russia and in U.S. or E.U.) within 30 days thereafter...
.
Familyman stated: "...mind-blowingly crucial data because it became available one week too late?!?! Unbelievable!!!"
Welcome to "The Bureaucracy"...contrary to KFCyahoo's response implying Leo controlled the RBL reporting results to IPIX (which he did and does not) and the deadline for the rolling grant review passed. But fret NOT...the grant application roles over to the next period and deadline...so my understanding is that the data information (and more) is in the next grant period for review.
Blaming Leo for RBL delays in assembling and releasing data which IPIX has/had no control over is a non-starter...pure BS. Of course, you won't hear from the same critic(s) throwing accolades in Leo's direction for submitting applications for Brilacidin's regulatory approval in two jurisdictions (U.S. and "Overseas").
Regarding IND...PR clearly states IPIX was complying with minor comments made by FDA re: IND application ...so IMO the answer is clearly YES: "...IPIX has been packaged the trial format the way FDA wants it."...and now we wait the 30 days. ... meanwhile IPIX has application in "overseas" jurisdiction for Human Clinical Trials for drug approval in that jurisdiction, which CT results will also be used in the U.S.
In the end..with Leo's strategy...IF INTENTIONAL DELAY...by FDA...after stellar results in Trials in U.S. and Russia and Russia's approval...FDA will have serious egg on its face and support a huge FOX New and FOX Business News campaign.
Meanwhile on the vaccine front PFE and Moderna are locked in "ONE UP ON YOU" trying to push the envelope on representations of efficacy....but SAFETY is far from settled.
IMO...discussion about AlfaSigma is a non-starter...because they are a non-starter with Brilacidin and likely default in its licensing agreement and return it back all of its rights under their limited licensed B-UP...good for IPIX.
With successful "overseas" trials and emergency approval...even without U.S. regulatory movement...YES, Kingofsting...IPIX can hit $5.00 by March.
Expecting IPIX to commence launch of Clinical Human Trials in Eastern Europe ...by end of November or first week in December with feedback on preliminary results very quickly...
wsbc cites Russia as the "Overseas" country and with IPIX (predecessor - B- Absssi trials)having past trials there, I would strongly concur...
If Russia, I would not be surprised we get "approval" shortly after 90(+) (-) patient trial is completed. The $ to be made is not the important factor...It prompts regulatory agencies from other countries to review and look seriously at Brilacidin for regulatory review and approval (including FDA).
Russia likely chosen for being both more responsive (if Putin wants it Putin gets it) and a quicker regulatory review /approval process and much less expensive than U.S. trials. (if the Hospitals charge at all...since they are in such a crises)
As per PR...balance of Clinical trials will be in U.S for seeking FDA approval
Rdunn88 you stated this AM:
LOL...
you state:
sunspotter is wrong...Operation Warp Speed also lessoned FDA time period for vaccine review and development
Sent to Rudy Giuliani and John McLaughlin
tiab...LAUGHABLE!
You state:
YOU QUESTION: "How is the (longs) TRUST LEVEL SO HIGH...?"
EASY ANSWER: SUCCESS and POSITIVE FACTS DO NOT LIE.!!!
Below...ALL FACTS!
October 2, 2020
INNOVATION PHARMACEUTICALS ANNOUNCES PRE-IND MEETING REQUEST GRANTED BY FDA FOR THE STUDY OF BRILACIDIN FOR THE TREATMENT OF COVID-19
September 15, 2020
LABORATORY TESTING OF BRILACIDIN FOR COVID-19 IN COMBINATION WITH REMDESIVIR REDUCES VIRAL LOAD BY NEARLY 100 PERCENT
August 26, 2020DR.
WILLIAM F. DEGRADO, A DISCOVERER OF BRILACIDIN, JOINS INNOVATION PHARMACEUTICALS AS SCIENTIFIC ADVISOR
August 24, 2020
COVID-19 DRUG CANDIDATE BRILACIDIN ACHIEVES A SELECTIVITY INDEX AMONG THE HIGHEST REPORTED, EXHIBITING POTENT ANTI-SARS-COV-2 ACTIVITY AT LOW CONCENTRATIONS; CLINICAL TRIAL FORTHCOMING
August 4, 2020
INNOVATION PHARMACEUTICALS AND U.S. REGIONAL BIOCONTAINMENT LABORATORY NEARING COMPLETION OF BRILACIDIN ANTI-SARS-COV-2 (COVID-19) IN VITRO TESTING
July 20, 2020
INNOVATION PHARMACEUTICALS’ BRILACIDIN INHIBITS NOVEL CORONAVIRUS (COVID-19) BY ALMOST 90% AT THE LOWEST CONCENTRATION TESTED TO DATE IN A HUMAN LUNG CELL LINE
July 13, 2020
INNOVATION PHARMACEUTICALS – CLINICAL TRIAL TESTING OF BRILACIDIN AGAINST SARS-COV-2 (COVID-19) TARGETED TO COMMENCE Q4 2020
July 7, 2020
IN VITRO TESTING OF INNOVATION PHARMACEUTICALS’ BRILACIDIN FOR COVID-19 SHOWS CONSISTENT ANTI-SARS-COV-2 EFFICACY; MANUFACTURING PREPARATION UNDERWAY FOR COVID-19 CLINICAL TRIAL
June 17, 2020
INNOVATION PHARMACEUTICALS’ BRILACIDIN INHIBITS SARS-COV-2 (COVID-19) BY 97 PERCENT IN A HUMAN LUNG CELL LINE
June 11, 2020
INNOVATION PHARMACEUTICALS COLLABORATING WITH REGIONAL BIOCONTAINMENT LAB ON GRANT APPLICATION TO RESEARCH BRILACIDIN AS A PAN-CORONAVIRUS THERAPEUTIC
May 26, 2020
INNOVATION PHARMACEUTICALS RECEIVES DATA FROM PUBLIC HEALTH RESEARCH INSTITUTE SHOWING BRILACIDIN INHIBITS SARS-COV-2 (COVID-19) IN A HUMAN CELL LINE
May 19, 2020
INNOVATION PHARMACEUTICALS’ BRILACIDIN REDUCES VIRAL TITER OF SARS-COV-2 (COVID-19) BY 75 PERCENT AFTER ONLY 1 HOUR OF PREINCUBATION IN IN VITRO STUDY AT BSL-3 FACILITY
May 5, 2020
INHIBITORY EFFECT OF INNOVATION PHARMACEUTICALS’ BRILACIDIN ON SARS-COV-2 (COVID-19) IN PRIMARY HUMAN IMMUNE CELLS TO BE STUDIED AT LEADING PUBLIC HEALTH RESEARCH INSTITUTE
April 27, 2020
INNOVATION PHARMACEUTICALS INFORMED NEXT PHASE OF BRILACIDIN CORONAVIRUS (COVID-19) TESTING TO BEGIN WEEK OF MAY 4
April 6, 2020
INNOVATION PHARMACEUTICALS IN DISCUSSIONS TO ADVANCE BRILACIDIN INTO HUMAN TRIALS AGAINST COVID-19
April 1, 2020
INNOVATION PHARMACEUTICALS RECEIVES DATA SUPPORTING BRILACIDIN’S DIRECT INHIBITION OF SARS-COV-2, THE NOVEL CORONAVIRUS RESPONSIBLE FOR COVID-19
March 17, 2020
INNOVATION PHARMACEUTICALS BRILACIDIN TO BE RESEARCHED AS POSSIBLE NOVEL CORONAVIRUS (COVID-19) VACCINE; BRILACIDIN NOW BEING TESTED AS DRUG AND VACCINE AT DIFFERENT INSTITUTIONS
Finally, how long once we get IND approval will it take to get the human trial going? Hospitals and protocol imo set up...but protocol would be changed if IND requires tweaking...a matter of days to modify protocol.
"DeGrado doesn't win the Nobel Prize"... I emailed Wm DeG the same...said I expect him on stage in Stockholm...in 2021. His email response came with a blush.
Coincidently the 2020 winners were for the discovery of Hep C Virus...wouldn't it be appropriate if Brilacidin could kill the Hep C Virus!!!
https://www.nobelprize.org/prizes/medicine/2020/advanced-information/
The 2020 Nobel Prize in Physiology or Medicine is awarded to Harvey J. Alter, Michael Houghton and Charles M. Rice for the discovery of Hepatitis C virus. Hepatitis, from the Greek names for liver and inflammation, is a disease characterized by poor appetite, vomiting , fatigue and jaundice - yellow discoloration of the skin and eyes .
LOL...worried that "Glowing" data and results of tests which will be in the Pre-Print of Peer Review Article from GMU scientists will turn heads?
IMO...you should be. Its time for Pre-Print...and IMO within the week we a "glowing" Pre-Print will be out.... Also for the public/public it will further supplement to and support for IND application submitted, though not necessary, since data would have been in the IND.
It is also good insurance that the "political" FDA cannot and will not bury Brilacidin and its results.
As noted, TRUMP card in Pre-Print Peer Review will be any discussion about tests involving Brilacidin with Remdesivir...IMO it can't and won't be ignored.
Political ... imo "save face" for Fauci's manipulation. Brilacidin will blow it away...as IMO will be demonstrated in the GMU Pre-Print Peer Review article.
imo...the pre-print from GMU is likley finished and submitted to company for review...I would expect, if I am correct, release sometime this week... real wildcard is what has been discussed in article about combo Remdesivir/Brilacidin and data demonstrating the workhorse is Brilacidin.
STRAWMAN/KNOCKDOWN ALERT!
IN RESPONSE TO POST REGARDING IND application etc...
The post sets up Strawmen and Knockdowns by asking the following questions (and makes assertion):
IN RESPONSE TO POST cited below, it is important to discern the difference between "fact" and drawing "false conclusion" based upon "false premises" or "false assumptions"
Every investor must be discerning about Posts using an event or non-event as "facts" and setting up "strawman" to "knockdown" thereby creating false conclusions and/or doubt, attributable to that "fact" used knockdown and create appearances of IPIX failure.
What are the the real facts here?
Loanranger... you repeat and state:
IND approval first required...likely Nov. 4th...no coincidence
Dr. Debones...you stated:
While no doubt...every age category could likely experience cases reaching mortality...
This link provided the most startling statistic that 42% of covid-19 deaths occurred in Nursing Homes and Assist. Living Facilities. (and that number did not reflect those transferred and died in hospitals). But it did reflect the mishandling of the crises by State Governors...who took their direction by listening to King Fauci and Co issuing guidelines (which changed almost every day in an ambiguous and contradicting way).
https://freopp.org/the-covid-19-nursing-home-crisis-by-the-numbers-3a47433c3f70
Some, like Cuomo, followed their own misguided paths...to exacerbate the problem with "non"-caring for the elderly living in these restricted facilities by mandating (executive order)them to take covid-19 elderly even though they could not safely do so...
https://khn.org/news/is-cuomo-directive-to-blame-for-nursing-home-covid-deaths-as-us-official-claims/
The interesting thing about the current spike in states that previously had very low covid-19 infection is that now they are exploding...and people are surprised...
Didn't it dawn on the experts that eventually, with a highly infectious disease...and highly mobile country, that everyone...with the exception of those "imprisoned" in their carefully restricted Nursing/Assisted living Facilities are likely going to be exposed?
It only takes one mobile infected person in this country to become a super-spreader...physical prophylactic's (masks and hand washing)...will never be 100% bullet proof.
IMHO...The only way to end the scenario/cycle is to develop and dispense a highly effective therapeutic to kill the virus upon contraction.
...has anyone here ever heard of Brilacidin?
(that's my one post for the day...and I can't respond if you comment on it)
Peter...also Regeneron-EI Lily antibody cocktail would likely be ineffective if the virus mutates to any meaningful degree. Remdesivir (without Brilacidin) is marginally effective.
Meanwhile Dr. Brian Garibaldi of Director, Johns Hopkins Biocontainment Unit, Associate Professor of Medicine and who is DJT's personal pulmonologist, and who treated and is treating him during this contraction of Covid-19...is being introduced to Brilacidin today. and IMO...he will get it immediately!
What he does with his new knowledge is anyone's guess...but when one reads "Remdesivir + Brilacidin" = 100% Covid-19 viral load reduction...it begs the next very serious investigative step.
Mutations will not reduce Brilacidin's effectiveness...since laboratory evidence has demonstrated it "pops and destroys" ANY "envelope shelled" virus...which is the structure of what Covid-19 and most other viruses are.
https://www.hopkinsmedicine.org/profiles/results/directory/profile/0018509/brian-garibaldi
https://www.msn.com/en-us/news/politics/johns-hopkins-doctor-among-those-assisting-with-covid-19-treatment-plan-for-president-trump/ar-BB19FT6P
ps...Peter...please look at your PM
KarinCA...you got it almost right...as I misspelled in the original post...the restaurant which hosted Minority Leader Kevin McCarthy for the Andrew Garbarino Congressional Fundraiser, on Sunday evening ... it was Verace at 599 Main St. Islip, NY 631-277-3800
As several have noted, when calling the restaurant you can only leave a message on the answering machine...and they will call back callers, assuming its restaurant related (and not Posters bothering them).
An easier way to possibly verify Congressman Kevin McCarthy's attendance and transmission of information referenced in the prior email...by emailing the staff member who accompanied the Minority Leader...which I will send you under PM. (he doesn't need to be harrassed by posters)
ps. KarinCA...food was delicious.
You do realize...if "ASPIRE ate the rally"...IPIX has a bit more money in its coffer!
Good news today...once IND Designation approved...Emergency Use Authorization is available...
Maybe W.H. would be interested in pushing IND through Immediately for DJT's EUA????
...can always speculate!
PS. Wrong on $10M for trials...hint in PR...
"Numerous hospitals and provider networks domestically and abroad have expressed a strong interest in participating in the Brilacidin for COVID-19 clinical trial."
Trial sites abroad ... could be 25% of the cost domestically!
IMO...Leo has the $ banked for the full 120 patient trial!!!
You questions:
Lemoncat...interesting comments:
Consistent!...TOTALLY INCORRECT STATEMENT:
VERY GOOD REASON WHY BRILACIDIN was not mentioned in NEW YORKER Article...
Article in these publications are summitted for Editorial Review at least 6 weeks before publication so they can be vetted for accuracy and verification of those quoted.
The New Yorker Article was PUBLISHED 09.18.2020
The article IMO was most likely submitted for Editorial Review on or before August 3rd.
IPIX appointed Dr. DeGrado as Scieintific Advisor on or about August 26th, 2020. (23 days before Publication of the New Yorker Article)
With Dr. DeGrado having conversation with IPIX before his appointment but not formalizing the relationship until on or about August 26th (Date of Announcement by IPIX)...the discussion of Brilacidin by Dr. DeGrado citing it in an Article to be published BEFORE the appointment would make the Citing of Brilacidin suspect (i.e. doing it to promote his financial interest?) and therefore inappropriate.
Therefore ... DeGrado did not cite it intentionally or if he did, the author/Editor chose not to report it.
REGARDING LEO'S EMAIL TO SHAREHOLDERS...The article not only validates the methodology of Dr. DeGrado's formulating Brilacidin to address bacterial and viral infections via De Nova designed drugs to mimic human proteins that serve as the front line of defense for the immune system...
IMO...we will shortly hear upon commencement of Human Trials (and superb success) that Brilacidin will be considered the first commercially available drug seeking FDA approval which was produced through this methodology...and it was done by DeGrado.
Re: New Yorker Article (Sept 20,2020) on De Novo Protein Design...to combat Covid-19
"Today, biochemists engineer proteins to fight infections..." " But “de novo” protein design—design from scratch—has been “the holy grail of protein science for many decades,” Sarel Fleishman, a biochemist at the Weizmann Institute of Science, in Israel, told me. Designer proteins could help us cure diseases;
In the nineteen-seventies, the pioneers of protein design worked by building physical models of their amino-acid chains. William DeGrado, a biochemist at the University of California, San Francisco, coined the term “de novo” protein design in the nineteen-eighties; he recalled, “I was told it was going to be impossible quite a bit.”
"Protein design is a two-way street: you must figure out how to... (do) does something useful, such as binding, antibody-like, to a virus. (as in Brilacidin?) A protein designer might start by taking natural proteins and tweaking them. ..."
"...Thanks to improved computational tools, including Rosetta, and faster methods for making and testing proteins, de-novo design has begun to show real promise."
“It’s amazing how much progress has been made, and how it’s just accelerating so rapidly,” DeGrado said. Baker agreed that progress was speeding up. “The fact that we’re spinning out a couple of companies a year is kind of remarkable,” he said. His lab’s work on covid-19 has convinced him that the grail is almost within reach. “The hope is that the next time there’s an outbreak, within two days, we’ll have models of candidates,” he told me.
IMO...DEGRADO DISCOVERED THE "HOLY GRAIL" DECADES AGO...and as it applies to COVID-19 (and other viruses) ... it's called BRILACIDIN!
BooDog...smart!
Time to accumulate is not after significant news...but before. I'm with you all the way...quietly accumulating each day at dips appear...
4th Q is 7 days away...looking for significant news before...but...
IMO..IPIX will deliver (even more) then promised in 4th Q and will blow "the mind" of the collective market, by demonstrating in Human Trials how extremely very effective therapeutic for Covid-19 B is ...plus open the door to even more revelations concerning the brilliance of Brilacidin design for therapeutic applications for other indications...via Dr DeGrado.
...on my way to to 3M shares
DaubersUP
...you are absolutely correct! LEO has done everything "by the book" and through Third Party Due Diligence (outside the company)...I have been informed that a recently departed Scientific Advisor to the VP Task force (who remains close to the Task Force) has reviewed Brilacidin ,filings. RBL results and background of Brilacidin...and he noted to a MD/former researcher, who requested the review, that "IPIX has done everything the RIGHT WAY" (methodically and no hype or bs)...and, going forward, is very bullish on the mechanisms of Brilacidin against Covid-19.
... all the disparaging and misleading and at times flagerlantly false commentary posted on this board about LEO and Brilacidin is obvious to those who know Brilacidin and what they own.
How close are we to hearing Brilacidin on major cable channels?... you be the judge! IMO...Brilacidin is in the countdown period for lift-off.
Ignore the flippers...
Smith... you state ( on a day of monumentally good news) the following:
"getting" ..."moving in the direction of"...many PRs cite doing so for Human Trials.