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we know there was no PR at 5:00 EST
Prusty does a lot of charity work for Kids with Cancer in Ontario Canada for the past several years. He raised $272,000 for a single golf outing. A Class Act -
I can speculate Wook, maybe he knows a kid in a Bavi Trial???????
-E
Merry Christmas to the entire board from me as well.
As a side note - and off topic, of course, but with political correctness mind, I think it is odd that we do not allow bibles in public schools, but encourage them in our public prisons.
KEEP CHRIST IN CHRISTMAS IS WHAT I SAY!
Since God works in mysterious ways, I wonder if there has ever been a more mysterious way than PPHM bringing Bavi to market?
I believe in the science of Bavi. I have done my own DD. I understand the composition of the BOD and how/why (IMO) they are there. I understand there a lot of very frequent posters on this board who are upset about the status quo at this moment in time. I understand that I need to simply sort through their propaganda. I understand that when certain posters (who's opinions I evaluate and thus learned to value) post I give more credit to those opinions. I understand that I must skip over the posts I give less credit to. I understand that is frustrating. I understand this and put my money where my DD sees fit, and I understand that is why I am heavily invested in PPHM.
May God bless us all!
-E
Honestabe13 - Congratulations on having post number 200,000 - wish that matched my number of shares
I Just noticed we have no moderators . . . What happened?
CJ is NOT on the board of Cryoport, and has not been for some time.
Corp - cherry picking Cryoport as additional information is not warranted since their share price is reflective of current pricing. Our esteemed COB is not longer on the board at Cryoport and has not been for a while. Feel free to verify!
Also, when our COB left Crypoport there was no immediate increase in share price. If he was the all encompassing reason for the poor share price, I think the price would have increased upon his departure, but alas - the share price did not increase with departure.
go PPHM - tx Lemmy
I consider the 3,000 soldiers as the healthcare workers, Not all "soldiers" carry guns.
This statement is the most profound, accurate, and reassuring post on this board in a while. But, of course, that is my opinion.
ENTDOC, I believe the interesting thing here to consider about Bavi and Ebola is that there are hundreds if not thousands of healthcare workers that are going to be put into harms way with deployment to fend off this hideous outbreak. Since Bavi needs time to "heat up the immune system" it could be taken in time to support and "bring forth" a more robust immune system just prior to even being on scene using the universal precaution protocol.
What are your thoughts about this??
-E
WAIT FOR IT > > > 8:00 am has come and gone and there still no news . . . yada yada yada.
But NO!
Jim - Keep your eye on the prize - despair not! Keep the faith . . .
Garnick is still highly involved!
See my post #192364
Garnick is still highly involved! You can either choose to believe me or not. No link, no source I and willing to divulge, and nothing but my word to prove it. By the way, not everyone's motive is sinister either. That is all.
-E
CJ is no longer on the board of Cryoport.
What time does the happy hour start on Friday's with the free PM's? I believed it was at 5:00, but does not seem to work. Can anyone help?
Thank you CP for you thoughts on this very important topic.
You gotta love the elevator music on the con call - I find it soothing . . .
Thank You for the response Eyebuy. I value your opinion on this message board, along with a few other people on this board, even though there is a bit of Jousting at times between them
.
EYEBUY-Will you provide your thoughts on the Proxy?
My thoughts on deals with the "big three" shippers of the world:
It does not matter as these shippers do not necessarily worry about "what" they carry as long as it is "safe", "lawful", and documented fully. The price of shipping with the "big three" will be based on the frequency of the shipping itself. The more they carry for Cryoport the lower the price goes.
Now the fact that they are willing to "carry" Cryoport's Shipper validates the integrity of the vessel itself (which is nice), but it is still up to Cryoport to get various customers to use their shippers. That will move the needle.
Agreed - how do you copy a link? When I do so it will not allow the link to paste for me - I must be a idiot (as I have a new computer with windows 8) and struggling with learning with new software - that bloody dashboard. -E
(EDIT) figured it out - hopefully -
http://www.chicagotribune.com/news/local/breaking/chi-cardinal-george-new-cancer-drug-20140822-story.html
Probably not Sunrise
(EDIT) Adding Link to source
http://www.chicagotribune.com/news/local/breaking/chi-cardinal-george-new-cancer-drug-20140822-story.html
August 22, 2014, 5:43 PM
Cardinal Francis George, facing his third bout with cancer, is participating in a clinical trial of a new drug being conducted at the University of Chicago, the archdiocese announced Friday..
"The trial is testing a new drug, which may work by activating cells of the immune system enabling them to attack cancer cells," the archdiocese said in a statement. "This approach differs from that of traditional chemotherapy, which uses drugs designed to be toxic to cancer cells."
The archdiocese said the new drug has shown promising results for patients with the same type of cancer as George, and the study is including a larger number of people.
George began taking part in the trial Wednesday, said Colleen Dolan, a spokeswoman for the archdiocese. Although the trial is relatively new, its outcome uncertain, the cardinal is optimistic, Dolan said."He's very hopeful, in his own words," she said.
The trial falls within the category of immunotherapy, or treatments aimed at bolstering the body’s natural defenses against cancer, said Dr. Thomas Gajewski, leader of the immunology and cancer program at U. of C.'s Comprehensive Cancer Center.
Those natural defenses can be weakened in cancer patients when “negative feedback cycles” shut off cells that would otherwise be attacking the cancer, said Gajewski, a professor of medicine and pathology. Experimental drugs seek to interrupt the feedback cycles, freeing the body’s immune system to fight the cancer.
In a similar study unveiled in Chicago in June, about three in ten patients with advanced bladder cancer experienced tumor shrinkage when treated with an experimental drug, he said. While much work remains, the results were encouraging for a drug so early in clinical trials, he said. “We’re very excited about the chance of these drugs to really help a large fraction of patients,” he said. George was initially diagnosed with bladder cancer in 2006. In August of 2012, he learned that the disease has returned to his kidney and liver, according to the archdiocese.
George is very lucky he is receiving his care at U of C. They do wonderful research, in depth and honest trials.
The cancer had been in remission for more than a year when George revealed in March that the disease "is beginning to show signs of new activity" and he was facing a "more aggressive" round of chemotherapy."
"This is a difficult form of the disease," the cardinal wrote at the time. "And it will most probably eventually be the cause of my death."
The form of cancer that struck George in 2006, called carcinoma in situ, was relatively unusual, accounting for about 10 percent of bladder cancer cases. The tumor was considered superficial — a flat growth limited to the wall of the bladder. But the cancer cells were of an aggressive type that could have spread rapidly to other parts of the body.
At the time, doctors did not believe the cancer had spread. But patients who have had bladder cancer are at increased risk for developing that cancer in their kidney or liver, outside doctors have told the Tribune.
Channeling your inner Dokken?Go PPHM!It is only a matter of time-EOM
Jim - maybe you better get working on the "plantibodies" web site domain name . . .
There is that "Monoclonal Antibodies" thing again. And a CEO getting out in the press saying . . . well something - anything. "Mapp CEO Kevin Whaley said in an interview at company headquarters in San Diego. "We would love to play a bigger role."
Hope that patent is "strong"!
Tobacco-derived 'plantibodies' enter the fight against Ebola
Aug 6th 2014 11:50AM
By Sharon Begley
(Reuters) - Drugmakers' use of the tobacco plant as a fast and cheap way to produce novel biotechnology treatments is gaining global attention because of its role in an experimental Ebola therapy.
The treatment, which had been tested only in lab animals before being given to two American medical workers in Liberia, consists of proteins called monoclonal antibodies that bind to and inactivate the Ebola virus.
For decades biotech companies have produced such antibodies by growing genetically engineered mouse cells in enormous metal bioreactors. But in the case of the new Ebola treatment ZMapp, developed by Mapp Pharmaceuticals, the antibodies were produced in tobacco plants at Kentucky Bioprocessing, a unit of tobacco giant Reynolds American.
The tobacco-plant-produced monoclonals have been dubbed "plantibodies."
"Tobacco makes for a good vehicle to express the antibodies because it is inexpensive and it can produce a lot," said Erica Ollmann Saphire, a professor at The Scripps Research Institute and a prominent researcher in viral hemorrhagic fever diseases like Ebola. "It is grown in a greenhouse and you can manufacture kilograms of the materials. It is much less expensive than cell culture."
In the standard method of genetic engineering, DNA is slipped into bacteria, and the microbes produce a protein that can be used to combat a disease.
A competing approach called molecular "pharming" uses a plant instead of bacteria. In the case of the Ebola treatment, Mapp uses the common tobacco plant, Nicotiana benthanmianas.
The process is very similar. A gene is inserted into a virus that is then used to infect the tobacco plant. The virus acts like a micro-Trojan Horse, ferrying the engineered DNA into the plant.
Cells infected with the virus and the gene it is carrying produce the target protein. The tobacco leaves are then harvested and processed to extract the protein, which is purified.
ZMapp's protein is a monoclonal antibody, which resembles ordinary disease-fighting antibodies but has a highly specific affinity for particular cells, including viruses such as Ebola. It attaches itself to the virus cells and inactivates them.
APPROVAL PROCESS
The drug so far has only been produced in very small quantities, but interest in it is stoking debate over whether it should be made more widely available to the hundreds of people stricken with Ebola in Africa while it remains untested.
"We want to have a huge impact on the Ebola outbreak," Mapp CEO Kevin Whaley said in an interview at company headquarters in San Diego. "We would love to play a bigger role."
Whaley said he was not aware of any significant safety issues with the serum. He would not discuss whether the company has been contacted about providing the drug overseas.
But he did note the novel manufacturing process carries its own risk, and would have to be cleared by the U.S. Food and Drug Administration as part of the approval process.
The FDA would, for example, have to be satisfied that the plant extraction process had not led to contamination of the resulting drug.
The tobacco plant grows quickly, said Reynolds spokesman David Howard, and "it takes only about a week (after the genes are introduced) before you can begin extracting the protein."
He declined to say how much medication each plant can yield or whether Kentucky Bioprocessing is in a position to produce ZMapp in significant quantities.
Scripps' Saphire said it can still take anywhere from one to three months to produce the ZMapp serum for wider use given the complexities of the process.
PENTAGON FUNDING
In 2007, Kentucky Bioprocessing entered into an agreement with Mapp Biopharmaceutical and the Biodesign Institute of Arizona State University to refine the tobacco-plant approach. The approach attracted funding support from the Pentagon's Defense Advanced Research Projects Agency (DARPA).
For all the hope, however, the plant technique has delivered few commercial products. In 2012 the FDA okayed a drug for the rare genetic disorder Gaucher disease from Israel's Protalix BioTherapeutics and Pfizer. Called Elelyso, it is made in carrot cells, and is the only such drug to reach the market.
Other companies have fallen far short, though it is not clear if the technique was to blame. Calgary-based SemBioSys Genetics Inc, which used safflowers to produce an experimental diabetes drug, folded in 2012 before it finished clinical trials.
Even Kentucky Bioprocessing, which at one point was developing monoclonal antibodies against HIV (the virus that causes AIDS), C. difficile bacterial infection, and the human papillomavirus, has dropped the last two projects, Howard said.
Last year Mitsubishi Tanabe Pharma Corp acquired a majority share of Quebec City-based Medicago, which is developing influenza and other vaccines using the tobacco-plant technology. The other 40 percent is owned by tobacco giant Philip Morris International.
They will probably announce tomorrow as I sold 2K shares today to cover an unexpected expense.
That would be my luck.
-E
Amen, Amen, Amen, Can I get a halleluja?
go PPHM!
REAL TIME QUOTE as of this writing - Patience people - the world is not imploding . . . .
$2.2699* 0.0001 0%
Conclusion Section of the Poster reads:
1. In the K1735 tumor model, animals injected with PS-targeting antibody (ch1N11) in combination with a-CTLA-4 or a-PD-1 demonstrated greater delayed growth, tumor growth suppression, and survival than a-CTLA-4 and a-PD1 antibodies alone.
2. In the CT26 tumor model, animals injected with PS-targeting antibody (ch1N11) in combination with a-PD-1 demonstrated greater delayed growth and survival than a-PD1 antibodies alone.
3. Animals that survive the initial tumor challenge develop tumor-specific protective immunity and are resistant to re-challenge of the initial tumor.
4. Tumors from animals treated with PS-targeting in combination with a-CTLA-4 antibodies show strong T-cell and macrophage infiltration by immunohistochemical staining.
NO MORE STEPPING AWAY FOR DAVE THEN!!!
MACD - what does that stand for?
HIV related article - woner what would have happened if bavi could be added to the cocktail. . . .
Baby Born in Long Beach Cured of HIV The baby girl is now 9 months old and shows no sign of the virus. Her mother, who has advanced AIDS and is mentally ill, arrived at the Long Beach hospital in labor.
Posted by Penny Arévalo (Editor) , March 06, 2014 at 09:14 AM
Comment01More
RepostPrintEmailFlag as inappropriate A baby born nine months ago in Long Beach with HIV and treated aggressively now shows no signs of the virus. Patch file photo.
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A baby born with HIV at Miller Children's Hospital in Long Beach nine months ago immediately received highly aggressive treatment with three drugs and now shows no sign of the virus that causes AIDS, it was reported today.
The revelation was made at an AIDS conference in Boston Wednesday, The New York Times reported. It follows last year's announcement that a baby born with HIV in Mississippi apparently was cured through aggressive drug treatment starting just 30 hours after birth.
Last year's announcement triggered skepticism, but news of the Long Beach baby leaves little doubt that the treatment works, the Times reported.
The first infant to make an apparent recovery from HIV infection, now famous as the "Mississippi baby," was described last March at the Conference on Retroviruses and Opportunistic Infections, the same annual meeting where the new case was reported.
Now over 3 years old, the Mississippi child remains virus-free, Dr. Deborah Persaud, a virologist who has run ultrasensitive tests on both children in her lab at the Johns Hopkins Children's Center in Baltimore, told the Times.
The baby born in Long Beach is now 9 months old and also apparently free of the virus that causes AIDS. Her mother, who has advanced AIDS and is mentally ill, arrived in labor; she had been prescribed drugs to protect her baby but had not taken them, according to the Times.
Four hours after the birth, a pediatrician, Dr. Audra Deveikis, drew blood for an HIV test and immediately started the baby on three drugs -- AZT, 3TC and nevirapine -- at the high doses usually used for treatment of the virus, the newspaper reported.
The normal preventive regimen for newborns would be lower doses of two drugs; doctors usually do not use the more aggressive treatment until they are sure the baby is infected, and then sometimes not in the first weeks.
"Of course I had worries," Deveikis told the Times. "But the mother's disease was not under control, and I had to weigh the risk of transmission against the toxicity of the meds. ... I knew that if you want to prevent infection, early treatment is critical."
The Long Beach baby is now in foster care, she told the Times. The mother is alive as well.
It is incorrect to describe her as "cured" or even as "in remission" because she is still on the drugs, Persaud told The Times. But because the most sensitive blood tests can find no virus capable of replicating, she describes the baby as "having sero-reverted to HIV-negative."
--City News Service
Good Morning WOOK - where is your good morning this morning - I miss that
My "broker friends" will not leave me alone today. I replied to them with a simple "I told you so".
What a great problem to have for us to have.
Poker night will be fun!
-e
34th Annual Cowen Health Care Conference
Date: Tuesday, March 4, 2014
Time: 11:20 AM Eastern Time
Location: The Boston Marriott Copley Place, Boston, Massachusetts
This event will not be webcast.
Anyone have a fly on the wall as to how this went. Too bad it was not webcast . . .
quote:
Like you, I am impressed by how much good will the people on this board can show when it is needed.
___________________________________________________________
agreed -
Let us keep this in mind as we are all in this together, and although we remain "anonymous", there are real people behind these posts, and what matters the most is fighting the scourge that is cancer. The time to beat cancer is now!
Let's sum it up this way . . .
CANCER SUCKS!
Bring on Bavi
My condolences to you and your family
Question for the board: How possible that the ATM has been used to acquire funds to pay for the CA settlement? Anyone?
Jim-maybe BOTH the Camaro & GTX