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I will be there. What is your view of the science?
Meeting with Kitov this week. Three years to deal....realistic?
I meet with them tomorrow. What’s the story here? Invest?
Odd is better than the other nnvc relevant term....shady
stock was halted for 5 minutes....
“ProMIS is in a unique position to contribute to and benefit from this unprecedented momentum. Our diverse portfolio includes differentiated antibodies selectively targeting toxic forms of Aß and tau along with robust discovery efforts to target additional misfolded proteins involved in neuroinflammation and neuroprotection. At the precipice of what is poised to be a radical phase of progress in addressing this devastating disease, we are invigorated by the promise of our path and steadfast in our commitment to patients, our investors and the research community at large.”
Elliot is presenting Sunday at CNS. I think that is in Boston....not sure.
Big potential here...
Talicia sales potential is an open question. That is why this isn’t at 20. That said, rdhl is an attractive acquisition target at 15-20 even with the unknowns.
Hard to figure demand for Talicia. I’ve never seen good statistics on number of patients that are treated for h pylori. I’ve seen how many have the infection, but many go untreated.
Biotech is risky I guess. Lol
I am attending for the 6th year in a row and IPIX is not on any of the agendas. That does not mean that Leo or whoever won't be there...just that they are not presenting. Attendee lists are not available.
This conference (really a bunch of conferences) is a freakin' gold mine.
buying a few more around 5.80
rumors at this point, along with company releases hinting at a deal by mid-year.
more info to come in the next couple weeks.
ProMIS Neurosciences Completes Second Closing of Private Placement
By Promis Neuro Admin on Dec 31, 2019 02:09 pm
NOT FOR DISTRIBUTION TO US NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES
TORONTO, December 31, 2019 – ProMIS Neurosciences, Inc. (“ProMIS” or the “Company”) (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases is pleased to announce that further to its news releases dated November 13, 2019 and November 18, 2019, it completed, on December 31, 2019 the second closing of its private placement. In the second closing, the Company issued 3,724,998 units (each a “Unit”) for gross proceeds of approximately CDN$745,000. The total gross proceeds raised to date under the private placement are $2,800,333.
In connection with the two closings insiders of the Company have subscribed for a total of 633,332 Units under the private placement representing approximately $126,666 of the private placement.
Each Unit issued in the second closing consisted of one common share of the Company (each a “Share”) and one share purchase warrant of the Company (each a “Warrant”). Each Warrant entitles the holder thereof to purchase one Share (“a “Warrant Share”) at an exercise price of $0.35 per Warrant Share at any time for five years from the date of issuance.
All securities issued in the second closing will be subject to a four-month statutory hold period in accordance with applicable securities laws. Net proceeds from the second closing are intended to be used for working capital and general corporate purposes. Closing is subject to TSX approval.
This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful. The securities issued, or to be issued, under the Offering have not been, and will not be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.
About ProMIS Neurosciences Inc.
ProMIS Neurosciences, Inc. is a development stage biotechnology company focused on discovering and developing antibody therapeutics selectively targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The Company’s proprietary target discovery platform is based on the use of two complementary thermodynamic, computational discovery engines – ProMIS and Collective Coordinates – to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique precision approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN, and on the OTCQB Venture Market under the symbol ARFXF.
Company documents relating to the fiscal year 2018 annual report can be viewed on the System for Electronic Document Analysis and Retrieval (SEDAR) at the link below:
https://www.sedar.com/search/search_en.htm
The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release contains certain forward-looking information, including about the timing and completion of the Offering, the receipt of TSX approval and the expected use of proceeds from the Offering. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company’s current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
For further information:
Visit us at www.promisneurosciences.com or follow us on Twitter and LinkedIn
To learn more about the role of misfolded toxic oligomers in Alzheimer’s disease, Parkinson’s disease and ALS, tune into Saving Minds, at iTunes or Spotify.
For media inquiries, please contact:
Shanti Skiffington
shanti.skiffington@gmail.com
Tel. 617 921-0808
For Investor Relations, please contact:
Alpine Equity Advisors
Nicholas Rigopulos, President
nick@alpineequityadv.com
Tel. 617 901-0785
That is certainly an odd view of the situation
So....98% decline in price should not be questioned.
Yikes!!
If Diwan can pull off a pipe or some kind of significant raise with NNVC ‘s flimsy record I would have to rank him pretty high on the all time scam list.
Fun to watch.
What an incredible scam. Best one I have ever seen.
I see this matched the all-time low today.
Wow. Almost like theracour was negotiating with itself. ....Oh wait.... That’s right.....
Nnvc ever get the rights to herpicide?
The sad truth is that BetOnMace was a failure. Prospects are bleak. The planned raise by lowering the price of warrants to $1.33 Canadian no longer looks possible.
Too bad. BetOnMace was simply underpowered. Any savior that will fund the needed “bolt-on” will exact a heavy price, leaving shareholders in the dust. If no savior appears, it looks like the IP goes to the bond holders.
Tornado rotation at the drain....
The statement in this release was optimistic to say the least
This one’s down about 40% the last couple weeks. In my view, it is like the head lower
cognitive results pres.
http://118009.choruscall.com/resverlogix/resverlogix20191206.pdf
ambiguous but holy cow!!!
CALGARY, Alberta, Dec. 05, 2019 (GLOBE NEWSWIRE) -- Resverlogix Corp. (“Resverlogix” or the "Company") (TSX: RVX) reminds stakeholders that the Company will hold a conference call and webcast on December 6th at 8:30 am ET to supplement the presentation of prespecified BETonMACE cognition results to be disclosed at the Clinical Trials on Alzheimer's Disease (“CtAD”) Congress 2019.
Among other findings, the Company will highlight that Apabetalone treatment illustrated statistically significant improvements compared to top standard of care placebo in cardiovascular disease patients with moderate to severe cognitive decline
Aducanumab is good; next generation Alzheimer’s disease therapies will be better. New data for aducanumab strengthens potential for Alzheimer’s therapy in near term, fuels next-generation therapies with more selective binding for toxic species of amyloid beta
GLOBENEWSWIRE 11:50 AM ET 12/5/2019
TORONTO and CAMBRIDGE, Mass., Dec. 05, 2019 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc.(ARFXF) , a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, commends Biogen for its trailblazing efforts to advance aducanumab. Data released today at CTAD (Clinical Trials on Alzheimer’s Disease conference) strengthen aducanumab’s potential to become the first disease-modifying therapy for Alzheimer’s disease. The data clearly underscore the need for next-generation drug candidates that offer more precise binding to the misfolded beta amyloid oligomer (AßO), the toxic species of the amyloid beta protein and root cause of Alzheimer’s disease.
“Today’s presentation reflects yet another landmark step toward the approval of a disease-modifying therapy for Alzheimer’s disease, which, we must remember, is currently the only top-ten cause of death without treatment,” said ProMIS Neurosciences(ARFXF) Chief Medical Officer James Kupiec, MD. “The aducanumab data is indeed good news, but the compound has limitations. History frequently shows that first-generation therapies for the most challenging diseases often have major efficacy or safety limitations. In heart disease, cancer and HIV, first-generation efforts often paved the way for better, safer medicines, and the same will be true for Alzheimer’s disease by more precisely targeting only the toxic species of amyloid beta and thereby avoiding the dose-limiting side effects associated with unwanted off-target binding. We will get there. Biomarkers will help us get there faster, but aducanumab is a tremendous first step.”
New data for aducanumab affirm a statistically significant reduction in cognitive and functional decline for participants in the EMERGE trial. As clinical benefit depends on the amount of antibody that can reach the pathogenic species of amyloid beta, data continue to show that aducanumab demonstrates limited selectivity for AßOs: off-target binding to amyloid plaque was associated with adverse and dose-limiting ARIA-E (brain swelling) in 35% of trial participants despite attempts to minimize it by titrating drug dosing.
PMN310 is a next generation drug candidate that offers more precise selectivity for AßOs, which is expected to provide greater clinical benefit and safety based upon current preclinical data. Created using a novel drug discovery and development platform that can uniquely and precisely target the toxic forms of otherwise normal proteins, PMN310 demonstrates a high degree of binding to toxic oligomers without binding to non-toxic forms of amyloid beta. Data also demonstrate PMN310’s greater therapeutic potency versus other Aß-directed antibodies. For more information about PMN310, please visit www.promisneurosciences.com.
To learn more about the search for therapies for Alzheimer’s, Parkinson’s and other neurodegenerative diseases, listen to Saving Minds, at iTunes or Spotify.
About ProMIS Neurosciences(ARFXF)
ProMIS Neurosciences, Inc. (ARFXF) is a development stage biotechnology company focused on discovering and developing antibody therapeutics selectively targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The Company’s proprietary target discovery platform is based on the use of two complementary thermodynamic, computational discovery engines – ProMIS and Collective Coordinates – to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique precision approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN, and on the OTCQB Venture Market under the symbol ARFXF.
Visit us at www.promisneurosciences.com, follow us on Twitter and LinkedIn
For media inquiries, please contact:
Shanti Skiffington
shanti.skiffington@gmail.com
Tel. 617 921-0808
For Investor Relations please contact:
Alpine Equity Advisors
Nicholas Rigopulos, President
nick@alpineequityadv.com
Tel. 617 901-0785
$350 in trading so far today. Not much...
That is certainly true. I do hope that an additional trial gets funded somehow. I think B has at least as good a chance as Soligenix' product.
For me, an insignificant result is not proof of efficacy.
I got burned by that investing mistake a couple times in the past.
There were no statistically significant results in the p2 trial. This is why it has been difficult to generate funding for the p3, and why BTD was problematic.
It has not been firmly established that B-OM works. As frol has pointed out, the opportunity is clearly there...but...
The issue with B-OM is there is no conclusive evidence that it works. Doesn't matter if it costs less, or if the market size is larger, etc.
long ride to zero
shorted years ago of course...
Shop themselves to anyone with cash? If they can’t engineer a sale, they will have to raise funds for ckd and/or vascular dementia trials. Will know more after we get more results this week
Were short positions covered Wednesday ... and if so, why?
I’ve been adding some over the past few weeks. I expect volatility as well.
You have to like the fact that they have continued to do what they planned to do.