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And company success and uplisting to an NYSE exchange, and financials worthy of inclusion in the Russell 2000, all of which are the direct result of competent management obviously have no bearing, so the fruits of these milestones, like institutions having to buy large quantities of company stock mean nothing. It's just "dumb money".
And a $3.5M+ Institutional Investment is somehow "dumb money"!!!
And 5000+ animal administrations with NO TOXICITY INDICATIONS WHATSOEVER is somehow proof "the drug is secretly toxic".
Vanguard Group is an Institutional Holder of NNVC stock, currently holding 800k shares with a value of over 3 1/2 million dollars!!! They increased their NNVC holdings by 600% basis the previous reporting period!!!
This is one of almost four dozen institutional firms who are now holders of NanoViricides stock:
http://www.nasdaq.com/symbol/nnvc/institutional-holdings
Having institutional investors is a DIRECT RESULT of the successful reverse split and subsequent uplisting to an NYSE exchange that the company orchestrated last fall.
Best to all!
And, Diwan 2011 share sales funding new drug production lab in a way favorable to shareholders was "insider dumping"!!!
Really excellent close for the week!
We added around 14% to share price this week, closing just below the week's highs, and well above the 200-day MA at 4.31. Today's early price action dropped to get close to the 200-day, but in a show of strength never actually touched it before racing back up.
So, my earlier numbers of $4.77 and then the $5 area would seem still to be in play. Again, that six month descending resistance line crosses at around $5, and if we can get convincingly above that, it suggests the start of a new bull run for NNVC!
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=104396331
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Quoting forum members to refute the expert opinion of an actual physician. Nice! Bold!
Then you state that these laymen opinions "confirm" your own negative belief, and that their opinions somehow make your own beliefs "facts"!
Well, the fact is you're totally wrong. Wrong on the "spooky" nature of the BBB relative to NNVC drugs, and wrong on your prediction that the BBB will cause tox studies to take years, or whatever.
People are smarter than to be scared by misinformation.
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Yes, it's a good thing, and no, it won't add delay to the TOX. People know better than to be scared by misinformation.
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Again, completely untrue. People know better than to be scared by misinformation.
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None of this is true. If there were to be any of the ill-effects postulated, they would have shown up in the 5,000+ animals tested in pre-clinicals. The fact that NanoViricides drug particles are able to cross the BBB is a good thing.
The postulations all sound so scary and ominous. Fortunately none of them are true.
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Seriously. People should do their own DD regarding NNVC.
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Ridiculous. Oh, and still waiting for evidence to support your wild claims regarding toxicity.
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You delay a TOX study if you don't yet have all the materials you need in order to conduct that TOX study. And then you build the production facility which will enable you to create the required quantities of the TOX materials, which they have now done.
If there were "issues with the toxicity of the drug" (which there are not) as you charge, then where is your evidence for such a claim? You have none, because there is none.
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Ridiculous on every count. Of course they will.
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Seriously Bloom, why is the truth so hard for you to believe? It's true that through all the years of pre-clinical testing, there has been zero indication of toxicity at any therapeutic dosage administered. If you had any evidence to the contrary (which you don't, because there isn't any), then I'm certain you'd have already disclosed it or linked to it.
Given that, why is it so hard to believe that perhaps the NanoViricides drugs ARE so non-toxic, that large quantities will be required for Toxicology Studies in which actual harm to the animal as a result of the drug itself is supposed to be demonstrated?
Best to all.
Wow, that's really well expressed! Much better than what I wrote. I'll keep this handy for the next battle, thanks!
Best to all.
Yes, looks like the 4p close was 4.56, down one penny from yesterday's close!
A very nice recovery from being down a few percent intraday, on a VERY negative day on the street! Certainly suggests the uptrend is intact, with the two levels I mentioned previously still in play -- $4.77 and the $5 area.
Best to all.
It's not clear when NanoViricides came to realize that they will need substantially more of the FluCide drug in order to conduct the TOX studies (five time more than they initially expected). Regardless, their only course of action upon realizing this fact was to construct the new plant in order to create the volumes necessary.
And that's what they did. The plant was designed, commenced, finished, and Monday is to receive it's grand opening. It is in this plant the company will make the balance of the drugs needed for the TOX. The company pursued, successfully, the only course they could take to create the materials necessary for the TOX. And this second production facility will soon come on line producing FluCide for the TOX studies.
Hardly the sinister situation some would suggest. Bullshit certainly is flying, but it's not coming from NanoViricides.
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Of course FDA will be happening!
Perhaps they will elect to conduct initial human trials in a country other than the US, but of course FDA approval, first of FluCide and later of all the drugs in the NNVC pipeline remains the company's primary goal. Trials conducted in Europe would be applicable to FDA approval requirements.
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NanoViricides has been hammered mercilessly for in the past publishing overly optimistic predicted timelines as to the approval process regarding their stable of drugs. So now, they're being hammered mercilessly for NOT offering a firm prediction relative to the beginning of TOX studies. Seems like some people want it both ways.
The company has explained the reasons for the delay in the commencement of the TOX, and those reasons are long-term very positive for the company's prospects. TOX studies are the next step toward FDA approval and licensing of their drugs, and TOX studies will at some point begin, hopefully soon now that the new facility will be able to greatly increase the rate at which test materials can be produced.
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How does that follow logically? They obviously know how to make the material in their smaller lab, so why is it so hard to believe they have the expertise to scale the processes up to produce larger quantities in a larger lab?
Why immediately jump to an unsupported negative conclusion based on neutral information?
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Your logic doesn't make any sense. In order to show the FDA and CDC the drugs have extremely low toxicity, the company has to first conduct toxicity studies to prove that fact it to them. Your reasoning is circular here.
Sometimes one has to step back and think logically.
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Next test is 4.77, the intraday high from June 24th. If we get above that we start printing fresh six month intraday highs again!
Really important that yesterday we blew through and closed above the 200 day MA at 4.31. We're now handily above all important intermediate-term MAs, so the TA now focuses mainly on past highs and psychological levels like say $5. If we get above 4.77, then $5 beckons.
The only other TA feature I see is a declining resistance line drawn through the spike peaks of 7.59 from Sept 25th and 6.65 from Jan 17th. That declining line crosses now just above the $5 area, and in a matter of days will cross below $5. That's two reasons for prices to test the $5 area near term, so I think it's likely to happen here.
So, that declining line around $5 is the top of the long-term triangle, and will be a very important test upcoming. A confirmed move above that line, if we get it, signals the start of a fresh intermediate bull phase for NNVC stock! If we don't get above it, we fall back and regroup.
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Not in this country, at this stage of the FDA approval process, legally, no. In some third world countries, possibly... but I don't think it would be smart for NanoViricides to provide drugs for that purpose. It would distract from the FDA process, be frowned upon by the FDA, would take precious drug quantites away from the FDA trial process, etc. If successful it would make huge headlines, but there would be reputational costs, I think.
That said, I, personally, would be willing to be administered a NanoViricides drug today. I, personally, believe that much in the safety and the efficacy, basis the pre-clinical studies.
Best to all.
Others can probably answer this better, but my understanding is the previous studies were designed to show efficacy of the drug at various dosage levels, not to test the limits of toxicity of the drug at higher dosage levels. They need, as part of the FDA approval process, to discover the dosage (relative to body weight, probably) at which the drug itself becomes harmful. Only when that's known can human Clinial Trial drug protocols be designed and administered to test efficacy in humans. This is the purpose of Toxicology studies.
Some drugs, like cancer drugs, have a very narrow range between efficacy and toxicity -- the level at which therapeutic effects are demonstrated is not far from the level at which the drug itself becomes dangerous. But as I said, the problem NanoViricides has is that their drugs have demonstrated zero toxicity in all previous pre-clinical trials at all dosage levels where therapeutic efficacy has been shown, so that point at which a large dosage becomes dangerous might be such a very high amount as to be difficult to test for and discover. Again, a good problem to have long term, but something that is causing us delays here in the toxicology stage of the approval process.
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Institutions now hold $11M of NNVC stock!
That's the most recent reported number from the end of calendar Q1, so therefore it's PRE RUSSELL INCLUSION! Now that NanoViricides is a member of several Russell indices, including the important Russell 2000, what will the numbers be in the next reporting period? We're at 45 institutional holders now. What will the post-Russell numbers be after mandatory purchases by various tracking funds and other followers of the Russell???
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http://www.nasdaq.com/symbol/nnvc/institutional-holdings
The reason TOX studies have taken longer than expected to begin is that NanoViricides has needed to produce far greater quantities of the FluCide drug then they initially expected in order to attempt to demonstrate toxicity.
The reason behind this is a good thing. It's because the FluCide drug has demonstrated NO TOXICITY in any of the 5,000+ animals to which it has been administered through years of pre-clinical trials. That reason, perversely, is a complication now as we await the beginning of TOX studies. It will, however, in the long run, be a huge positive.
The drugs have proven so non-toxic in pre-clinical animal studies that they might need to make enough to just drown the animals in it for the TOX studies, because that might be the only way to show any harm.
It's such a strange problem to have, one that's causing delays here at this early stage, but a problem I'm happy to have. And we now have the new production facility completed and soon to begin drug production, greatly increasing the quantities that can be produced. We're nearing the end of the wait for TOX to begin.
Best to all.
Yes, exactly! Diwan's comment isn't the secret key to the grand conspiracy! Despite the fantastic imaginational powers on display, the Bilderberg group and Glen Beck have nothing whatsoever to do with NNVC. Honestly...
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So a rising share price is bad, and a falling share price is bad. That it?
SUSQUEHANNA INTERNATIONAL is an Institutional Holder of NNVC stock, currently holding 160k+ shares, over $700K worth!!!
This is one of almost four dozen institutional firms who are now holders of NanoViricides stock:
http://www.nasdaq.com/symbol/nnvc/institutional-holdings
Having institutional investors is a DIRECT RESULT of the successful reverse split and subsequent uplisting to an NYSE exchange that the company orchestrated last fall.
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Just printed 4.50, matching HOD yesterday! If we get above that... then we'll probably spurt higher.
The total number of shares Dr. Diwan sold months ago over the many month period in question is minuscule relative to average daily volume. Terms and phrases like "unload", and "let the stock recover" are not applicable given the actual situation. Dr. Diwan's sales were not significant relative to share price movement -- they were too small and too spread out.
Further, the sales were to facilitate financing of the new production facility, which overall was a very positive arrangement for shareholders.
Best to all.
There never was one in the first place.
It wasn't a complete pattern (no shoulders), and regardless, recent bullish price action has invalidated whatever imaginary setup some people professed to exist.
Looks like path of least resistance is now higher.
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There are 45 institutions on the list Weedie, soon to be many more after the compulsory adds due to the inclusion in the Russell indices!
Best!
Institutions now hold $11M of NNVC stock!
And those are PRE RUSSELL INCLUSION numbers! Being now a member of several Russell indices, including the important Russell 2000, will significantly add to that number in subsequent reporting periods.
I guess we should all praise Drs. Diwan and Seymour for their proficiency at "company orchestration"! Yah!!!! Let's hear it for "company orchestration"!!!
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http://www.nasdaq.com/symbol/nnvc/institutional-holdings
GOLDMAN SACHS is an Institutional Holder of NNVC stock, currently holding 200k+ shares, close to $1M worth!!!
This is one of almost four dozen institutional firms who are now holders of NanoViricides stock:
http://www.nasdaq.com/symbol/nnvc/institutional-holdings
Having institutional investors is a DIRECT RESULT of the successful reverse split and subsequent uplisting to an NYSE exchange that the company orchestrated last fall.
Best to all!
The reason results in humans trials will likely be similar to those found in pre-clinicals in thousands of animals across multiple species rests in the manner of operation of NanoViricides' drugs.
Highly unusual relative to other types drugs, Viricides act totally independently of the animal's immune system. The Cides operate directly on the virus in the medium of the bloodstream. They attach to the virus particle in the bloodstream and physically rip it apart, harmlessly spilling it's contents. NanoViricides' drugs are specific to viral particles, while being agnostic as to host. There is therefore no anticipated scientific reason for human efficacy to be different from that demonstrated so overwhelmingly in pre-clinical animal studies.
Further, another potential for harm is avoided basis the fact that the Viricide drugs do not enter cells. They remain in the bloodstream. So, no interactions with species-specific structures.
So, we have our two factors. One, the drug's mechanism is likely to function perfectly as well in humans as it does in other animals because there's nothing specific to humans that's required for efficacy. And two, zero toxicity has been demonstrated in any animal tested in pre-clinicals, and there's no anticipated mechanism relative to humans which might cause an issue.
True, it will only be after the completion of human clinical trials that these statements are proven. However, appropriately so, share price currently reflects the pre-clinical status of the company's research. Huge share price appreciation will come as we get further down the road.
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It's the most current information, but yes, it does pre-date Russell inclusion. It's current as of the end of March, so end of calendar Q1. It's the second report since uplisting, and is broken down into changes from the first report that was dated the end of last year.
So, I agree, I expect a large INCREASE in institutional holding basis the Russell! Thanks for bringing that up!
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Yes, NNVC now has 45 Institutional Investors, holding a total of over $11M worth of NanoViricides stock!
What's most interesting is to see the changes which took place this reporting period basis the previous period:
New: 17
Increased: 26
Decreased: 9
Sold Out: 3
So, 26 increased their holdings, while only 9 decreased. That's almost a 3:1 relationship.
Seems like a real vote of confidence!
Best to all.
http://www.nasdaq.com/symbol/nnvc/institutional-holdings
Vanguard Group is an Institutional Holder of NNVC stock, currently holding 800k shares!!! They increased their NNVC holdings by 600% basis the previous reporting period!!!
This is one of almost four dozen institutional firms who are now holders of NanoViricides stock:
http://www.nasdaq.com/symbol/nnvc/institutional-holdings
Having institutional investors is a DIRECT RESULT of the successful reverse split and subsequent uplisting to an NYSE exchange that the company orchestrated last fall.
Best to all!