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Actually, the granting of the EU bio-terror patent is a Big step forward. This is a valuable and forward-looking patent, especially in our times.
A lot can be done with this article to make it go worldwide.
In response to questions: In my view, the AS system is the only one around that could work in a space station, for microbe-free maintenance, or for emergency decontamination. A recently fully documented phenomenon is that microbes wildly proliferate on astronauts' skin flakes that fly everywhere. The normal skin contains all manner of Staph, Strep and many anaerobes as well, all capable of turning highly pathogenic, thus potentially dooming a mission.
O3 and H2O2 degrade to oxygen and water, leaving no residue, as contrasted with other systems. Of course, sections of the craft would have to be walled off in succession. As for the safety of electronics and other equipment, my contacts tell me that all materials on spacecraft are highly ozone-resistant.
It is now well known that space stations are perfect breeding grounds for all manner of bacterial invasions. In addition, many microbes proliferate faster in zero gravity. Authorities know that this could easily spell doom for a mission:
http://theconversation.com/bacteria-in-space-why-the-international-space-station-is-riddled-with-germs-49827
Hopefully MZEI management has contacted NASA about testing and possible applications of AS for this huge problem, which Must be addressed before any mission to Mars.
Knowing how ORs work, I agree with you.
The one viable path I am certain would work in "Plan A' is the disinfection of hospital patient rooms. Patients are not satisfied with mops and Clorox and such. They want to know that any traces of the last occupants were blasted away and that they will have a better chance of walking out of there without a HAI.
Poll: Where's the problem?
Modern medical equipment is designed to be highly resistant to oxidizing gases, ozone included.
If one does the math, it seems clear (to me) that sterilization of patients' rooms would be not only more profitable on a sheer numbers and turnover basis, but also time-saving (patient rooms have fewer openings to be taped), and more efficient in terms of stemming infection propagation.
Operating theaters are now ever larger to accommodate bigger equipment and have many more openings to plug. Being larger, will they need more treatment time?
So why the hold up? Medizone has one or more lawyer-experts on EPA matters. Contacts are made daily or weekly, so why no updates?
Thanks Gelati. I agree that ORs need periodic sterilizations. Those would have to done at night and then only a certain percentage are available for cleaning, it all depends on patient traffic. As for patient rooms, most modern hospitals are two or 4 to a room, so it's hard to time it that rooms will be totally vacant for cleaning. The high-end hotel or cruise ship cabin whose new occupants want a norovirus-free room and vacation, that could work.
People are ever more uptight about entering a hospital and especially staying in one for any period of time. They show you a room and you say, "who was there before me and what did he/she have?" "Is is really clean? Can I get infected with one of those weird bugs?"
Because more and more people hear about HAIs and the damage they can do, hey, you can croak if they come around your wounds and tubes!
A hospital room guaranteed to be microbe-free is, in my opinion, the way to go. Doubtful that hospital administrators will OK AS filling an operating theater with O3/H2O2 with $millions worth of top-of-the-line medical equipment. Plus, you'll use a lot of tape and time sealing it each go around, not efficient.
That said, the draw of a fresh pristine hospital room is hugely attractive and the demand can be enormous (and profitable).
Thanks Joe_NY. The "service" is just a phone answering service. Many of the queries received get most of their info on iHub. It seemed more efficient for now to post my answer rather than to respond individually.
In response to the messages received on my service, my advice is to Hold.
Any denial by the EPA at this time would be very heavy on (its) responsibility. Here we are at a time when the factors that make for emergent epidemics are all on the upswing: world population, rapid travel, massive animal farming, global warming, etc., all contributors to "perfect epidemic storms." MERS, SARS, Ebola, Avian flu, HAIs, and now Zika and many others, these pathogens are hardly standing still! So here we now have a technology that contributes significantly to inhibiting the progress of current and future epidemics by clearing health care facilities of epidemics' nurseries.
Delays in approval can hardly be excused!
A and B plans can be concurrent, actually synergistic. And also, for "Plan B," patents help a bit but are not all that necessary.
Actually, a plan B centered on wound healing with topical O2/O3 would be relatively straight forward to launch. Medizone, under the umbrella of its patent, could build a medical ozone generator dedicated to the assisted healing of such conditions as diabetic and vascular skin ulcers, burns, decubitus ulcers (found in nursing homes and the chronically bed-ridden), and complex trauma such as war wounds where wound infection is a problem (ozone inactivates All microbes growing on wounds). The machines would be accompanied by tutorials and protocols geared to each of these clinical situations. Medizone could host training seminars (already some people are currently doing this in the US). These dedicated machines could then be shipped the world over, where there is ever increasing acceptance and demand (there are currently no machines available that are compact, sturdy, reliable, and reasonably priced). Revenues to the company would not only come from their sale, but importantly, from the sale of peripherals needed in these therapies. Also, there is a massive human need!
Many states have OK'ed externally applied oxygen-ozone gas mixtures for more rapid wound healing, and the number is growing. You figure that this mixture inactivates all manner of bacteria, fungi and protozoans growing on wounds, And, their toxins, which inhibit wound closures.
The study in question was definitive: The addition of O2/O3 gas mixture to conventional measures speeds healing…which also means lower numbers of amputations (about 100,000 diabetes related amputations a year in the US alone)!
Not sure about EPA approval, I doubt it would be needed.
Re bugs and ozone. Insects like bedbugs, roaches and ticks among others have long been known to be extremely resistant to all manner of noxious agents. Many can simply stop breathing and reduce their metabolism. And try killing a bedbug when it is well hidden deep in a mattress. The company spent time and money needlessly on the ozone inactivation of bedbugs.
On Plan B… Medizone still holds an USPTO-issued patent, " Apparatus for the application of ozone/oxygen mixtures for the treatment of external pathogenic conditions" USPTO No. 6,073,627. It has about 5 years to go. Al that would have to be done is to revive this patent and announce a clinical study on the healing of diabetic skin ulcers in a Tier One country (One has already been done and the results are quite successful). The stock would soon climb to dollars. The promise for the healing of diabetic skin ulcers and the reduction of limb amputations is huge. We have 25 million diabetics in the US and 15% develop skin lesions. Wound healing was a 20 billion market in 2015.
In response to several people: self-destructive behaviors do exist.
Although ZIKA is spread through mosquitoes, it still causes a viremia, which is a phase of virus replication where billions of viral particles flood the blood. As such, body fluids are infected. There are reports of bodily fluid transmission, including sex.
It seems to me, if this epidemic is to be mastered, that any infected patient having a surgical procedure, or a birth delivery in hospital or clinic, etc., should have the facilities thoroughly disinfected after the event.
Brazil is frantic to get the Zika virus epidemic under control before the Olympics. This is yet another opportunity for Medizone to be center stage.
There is a large active Brazilian Ozone Association , and from experience, well connected to health authorities there.
New CRE Family of bugs:
https://www.washingtonpost.com/news/to-your-health/wp/2015/12/03/superbug-known-as-phantom-menace-on-the-rise-in-u-s/
There are parallels between the scenarios of climate change and microbial evolution, now rapid.
WHO influence has been vastly underestimated.
In dealing with Saudi health professionals and health authorities, the valor of the product is only rivaled by diplomacy itself.
If the News is as strong as it seems to be, hopefully there will be successful contacts made with serious media such as the New York Times (business section), the Boston Globe, the Wall Street Journal, etc.
If the News is commensurate with the expectations, there will be jubilation. If not, what will be the shareholder reaction?
I guess they thought the wound healing patent had no value and decided to stop sending the USPTO the patent maintenance fees.
The following is a serious and definitive study entitled “Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers,” that demonstrates the benefits of topical oxygen/ozone in healing diabetic skin wounds. 61 patients is an ample sample size. Results showed that topical oxygen/ozone treatment, in addition to conventional treatment, was significantly superior to conventional treatment used alone. In the U.S., of 25 million diabetics, up to 15% develop skin wounds and infections.
Medizone currently has a patent on this process!
http://www.ncbi.nlm.nih.gov/pubmed/21751891
There are dozens of publications worldwide that would love to broadcast the Medizone story.
Thank you for the depth analysis. Foresight, forethought, ability to grasp complexities, capacity to apprehend possible future obstacles, all at a premium.
Just the news of a Medizone sponsored clinical study on ozone-assisted healing would pique the world wound healing community's interest (and spur the stock).
I agree with you on your points, 5 years is a short time. However, Medizone has the only patent in the US on wound healing with external oxygen/ozone gas mixtures, proven to accelerate wound resolution via its amazing capacity to inactivate all pathogens.
On a typical diabetic ulcer wound, for example, studies have shown that there may be upward of 20 different families of colonizing bacteria and fungi. Ozone inactivates them all. With some 80,000 amputations annually in the US due to diabetes alone, this represents a huge human need. Medizone could have developed small portable specialized ozone units for wound care for nursing homes, etc. Also, it could have done landmark conjoint clinical studies on wound healing with universities (maybe in Canada).
Medizone still has in its possession a USPTO-granted patent on ozone-assisted wound healing: “ Apparatus for the application of ozone/oxygen for the treatment of external pathogenic conditions,” USPTO # 6,073,627. It has 5 more years of life to go. Wound healing now commands a 20 billion annual market worldwide. Medizone could still become a genuine medical ozone company, in addition to a sterilization company.
The Middle East Ozone Association (ME-O3A) is very influential in Saudi Arabia and it would be to Medizone's advantage to contact them.
Ebola viability on surfaces is surprisingly high:
http://www.livescience.com/50758-ebola-virus-survival-surfaces.html
Hunch EPA will come through soon, too many things going on worldwide not to.
While the EPA has mounds of data on ozone and on hydrogen peroxide, few papers are published on Trioxidane. I have been thinking all along that this was the reason for the approval delay.
The administration initiative is good news for Medizone. A request for fast-tracking EPA approval is likely to receive added attention. I trust they have done so already.
Talking to a good number of investors on a regular basis, the pulse of opinion is that a vote to increase the number of shares, at this point, would be a hard sell. Try as I might to recommend holding on, the tide of gripes is strong, the main one being the lack of updates.