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Sanoman........John, sorry that link to article is closed but you may want to bookmark Eurek for various articles (good link).
Article - "Secrets of Drug Resistance in Bacteria"
Dan Krotz @ lbl.gov (DOE/Lawrence Berkeley Nat'
Lab.
http://www.lbl.gov.
May 9, 2003 issue of Science
Basically the RNA changes protein(s) within the bacteria making them drug resistant. Alot of the reasons are still unknown at this time. It doesn't seem to be related to the antibiotics (but that could change and it could vary as to the species of bacteria - the major problem now is the "golden" Stayh. aureus species resistance even to the "big gun" antibiotic Vancomyacin - the antibiotic of last resort.)
I think science and medicine are running scare right now on what is transpiring - it's getting out-of-hand! I know I am.
Google will bring up some good articles - but suggest you read the watered down versions, as I do, from Science and Nature.
More to come I hope. But right now it's the protein within the bacteria changing and as mentioned by "BigB" (post #4033) its not considered a "real mutation" because it is not pasted on to future bacteria (?) - so its not evolution but it does work for the "bugs".
Rick
Sanoman........John, sorry that link to article is closed but you may want to bookmark Eurek for various articles (good link).
Article - "Secrets of Drug Resistance in Bacteria"
Dan Krotz @ lbl.gov (DOE/Lawrence Berkeley Nat'
Lab.
http://www.lbl.gov.
May 9, 2003 issue of Science
Basically the RNA changes protein(s) within the bacteria making them drug resistant. Alot of the reasons are still unknown at this time. It doesn't seem to be related to the antibiotics (but that could change and it could vary as to the species of bacteria - the major problem now is the "golden" Stayh. aureus species resistance even to the "big gun" antibiotic Vancomyacin - the antibiotic of last resort.)
I think science and medicine are running scare right now on what is transpiring - it's getting out-of-hand! I know I am.
Google will bring up some good articles - but suggest you read the watered down versions, as I do, from Science and Nature.
More to come I hope. But right now it's the protein within the bacteria changing and as mentioned by "BigB" (post #4033) its not considered a "real mutation" because it is not pasted on to future bacteria (?) - so its not evolution but it does work for the "bugs".
Rick
Sanoman......John, Check out this version of a Nature article on Drug Resistance in Bacteria when you get a chance and I'm sure Thalio (et.al.) will have more on this.
http://www.eurekalert.org/pub_releases/2003-05/dbnl-sod050903-php
Rick
OT...Thalio...Thats exactly what happen to me. I mispell
something on Google and it starts thinking for me which is great if Google is right. Also, right again on people writing these things. It's no better than what they put in.
Noticed that we're changing genus names on some species of bacteria related to genetic which is fine but I do have to keep up on these events.
Thanks for all the microbiology data today.
Looking forward to Dr. Chen's Biochemistry Journal "Spesis' article.
I haven't gotten it via email yet but there was a report it's out.
Guess we will get feedback on this article for months.
Hope we can get it down to the news media for everyone.
Rick
P.S. I was Gooling a research book on the Muhlenberg (Bog) Turtle (smallest USA Turtle) - one hit on Google showed a photo of a Bog Turtle ---- It was a very large Snapping Turtle.
Thalio......I noticed the same thing on Google and thought I was seeing a new species mutate right in front of me.
Sometimes (?) Google will take your inquiry and correct your input with the correct name at the top but it's unusual.
Having kept a Stayh. aureus gram positive very close company for four years of osteomyelitis (1992-1996) - we were on a first name basis. We had a small reunion last November 2003 until he got kicked out again.
Anyway you look at it, these "bugs" have got to go!
Percy......noticed that. Only thing I know that is coming up is Dr. Chen's article on SPESIS in Biochemistry Journal (maybe 18th or 19th of Dec?). Now weather that will start a buy on CYGX - who knows.
Of course with CYGX, anything coming up is possible!!!
Rick
Random thoughts on SPESIS............Tatonkano post #4141
is worth a second look.
Statement has been made that an average medical case of spesis costs $50k and that the ecomonic burden in USA is $17 billion a year (figures for 2002 because it goes up 25 to 50% each year). I wonder if these figures included the litigation that can become a part of a spesis case? Of course not! And these figure's are grossly conversative.
What is very scary is the figure of an incidence in 1979 of 164k cases of spesis (deaths were relatively lower in 79) while in 2002 there were 215K deaths from spesis. So there are more deaths now than there were cases 23 years ago. This has happened because - not so much, dirty OR's in hospitals but dued mainly to drug resistance in rather ordinary bacteria - namely Stahy. aureus. And sometimes because of this growing resistance in bacteria - doctor's have a reluctance of using antibiotic routinely in surgery. (i.e. any bone surgery should be covered by IV antibiotics - my opinion is not shared by all).
Back to figures (which canbe misleading). 1979 cases of spesis were 164k - now in 2002, we had 750K cases. Are they talking about drug resistant bacteria spesis or a spesis case which is responsive to antibiotics. Probably (I hope) the latter. In anycase it incrediably high and growing each year.
If everything continues in this fashion, surgery will become extremely dangerous and elective surgery will be something to think about strongely. And antibiotic's will become useless in the future. I guess we all knew that was coming but not this fast.
So bottom line - we got a major problem in spesis in medicine and you cannot make new antibiotics overnight or even in years and even if you could it wouldn't matter because the bacteria will become resistant to them.
Seems like the work CYGX is doing is rather impt.
You will notice alot of news stories on this subject for the next few months - one because of the usual "piggy-backing" in jounalism and two it's deadly impt.!
Some years ago, doctors recieved numerous bulletins from CDC regarding various diseases, especially infectious diseases. Money cuts stopped these bulletins - they were very impt and kept one alittle ahead of the curve. Maybe we should have not stopped the bulletins - maybe we would have been smarter about these things.
Best - Rick
Holycow....I would like to "second" your great words regarding Skooby and his unique posts - in time we will look back on his posts with great admiration.
The series of "Skooby posts" yesterday are worth a second read.
Best - Rick
Thalio......thanks for your posts today (and always). You out did yourself. I think I sense heavy excitment on your part today. You talent and knowledge have no limits !
Neo43....good information (I take its from CYGX). Your right Isis was among others which had run into all sorts of unfavorable environments within the blood stream towards naked oligos and it has been discouraging for antisense in general but as you point out, CYGX will be that much more advanced having those shortcomings to learn from and benfit by. And that is why I say (and Thalio says, you and others) that there will be alot of time taking repetition, etc in the spesis treatments / experiments. It will take time but it will well worth it and there will be news as we progress.
Meanwhile there will be numerous events to strengthen PPS and CYGX in general.
Again, talk now of joint-ventures / licenses for funding possible. Thats great! You get one - others will follow. Stronge backers here some with deep-pockets that are open.
And meanwhile we are in the middle of Herpes simplex animal studies soon (approx. April 2004) to be FDA P1&2 studies possibly conbimed(should be fast-tracked considering the impt of such). Human studies to be started in a large Asian country which will provide great data and a great future. This will strengthened PPS and CYGX statue. Incredible markets hard too measure in $. Great GOOD.
On top of this, when PPS gets to a certain point, institutional involvement will happen. Studies will come out by analsyt will peak the markets interest.
One downside - it won't be a $.50 stock anymore. We will wish fondly about those days ! You know what to do now !
Now I have left out alot - the neoplasia studies which will be giving peroidic news. Anit-inflammatory Rx's coming to light. 10's billion of dollars in that market and alot of good.
Human alopecia Rx's - various skin disease Rx's and new areas we haven't even talked about because there are those 800 oilgos out there that are identified but you don't heard about them working too well. Perhaps CYGX canbe of assistance to some of them and they are in every clinche of human and animal pathology that is conceiveable !
Now I have said this before and many others have said this far better than me many times over. I am rehashing this just so we can review it for the downsides which I'm sure will pop up from time to time. I'm excited about this !
We have alot to look forward too. It's not a done deal by anymeans but it has a better than great shoot at it. Better than most ! And its got a GREAT BOARD here.
We're not a one or two product BioTech - we're a medical rainbow just waiting to happen.
Best - Rick
CYGX........it's just hard to believe what is possible here.
I think thats what others, who have not studied this patent, our thinking - it's impossible. But the fact of the matter is, it isn't - the jury is out right now, but it is possible and in a major way unknown in medicine.
We all have to understand, we see this in an entirely different fashion because we have studied what is possible.
It is going to be a trip to sit on the sidelines watching the world become aware of this new science !
Regarding delivery of Rx for spesis.....Antibiotics (the old method?) are given orally, as in taking a pill or liquid solution which must be absorped in the gastrointestinal system (some are absorped better than others - this is an impt) - others are given intra-invenous (veins) - this methods get into the vascular system faster and builds a blood level faster and faster vs oral adminstration - intramuscular or subcutaneously routes are common, again the blood levels and time to develope blood levels vary in time and in the level developed, occasionally there are indications to give medication into a body cavity such as the abdomen and / or chest cavaity (use less) There are advantages at times to this such as in a peritonitis (infection of the adbominal cavity).
I wouldn't be surprised if these experiments use several methods of introduction to see which work better - maybe this has been determined already. In anycase to get something into the blood stream these are the the various methods of introducing a drug into the organism. Measurements of blood levels will be determined with each method. The amount given be measures vs blood levels reached in the organism.
One other point - with bacteria you have both gram positive and gram negative organisns. It's great that the method of death will get to all gram positive - the most common and the ones that are giving the most trouble mutating right now. But gram negative bacteria are quite deadly and I'm sure CYGX has plans for those nasty little bugs (i.e. pusedomonas bacteria). There are an array of other infectious organism - it's somewhat endless and I'm sure that CYGX "ssDNA" gene silencing canbe be adapted to many if not all of these pathogens. Which is truly great!
Consider the Spirochete in Lymes Disease for just one.
All of this is truly fantastic and "earth shaking news" as Hogger says. Just think about the news media when the first studies are released but remember these studies must be repeated - refined - verified - and reapeated. You've got to get it perfect to be accepted.
Best - Rick
OT.....Saddam Hussein captured w/o event. Let's pray this can lead all to reconstruction and peace in our troubled world.
T........passing the CYGX site is a good idea. Sooner or later you will hit someone who is going to look into it and take interest. I had a few friends in NYC that were free lance science writers back in late 80's. They were all quite bright. It always was a time thing with them or lack of it.
OT......Mick Jagger gets Knighted !!! eom
Neo43.......Thanks for the reply about RB.
The article on financing - it is good and it's great for our future - you may want, if you're willing, to email it to Lawerence (CEO) at CYGX. It's a fast read and you never know when these things "click" for some reason.
Best - Rick
elsieCat......thats a hell of good idea on your part!!!
I will attempt to do it but, please, other posters feel free to try to contact her also. Can't hurt at all.
I will also send it to CNN Breaking news with a short cover letter but it would have to be a slow news day for them to notice it. It can happen because it's not just a good story but very impt. these days.
Great idea "elsieCat" - Thanks alot!
Best - Rick
neo43.......Rick here, is that you over at RB (posting under
neo____43)? Just checking. I had a problem with RB not recognizing my email address so I can't post under my handle. TIA
Orygun......Beaufort, S.C. here - it is cold this am - but about EDIG.
EDIG......surprise webcast for EDIG on Thrusday - December 18th, 2003 at 1:30pm PST to address business developements (mentioned large Asian OEM) Could very interesting. Check EDIG here at IHUB.
EDIG just had a SHM so this is abit of a surprise. Stock presently in mid $.40's.
cygxup......very impressed by your knowledge very quickly and your question which I will let Thalio answer in his usual "brillant' and commonsense way.
But heres a short shot.
The CP4 (ICP4 - infected cell polypetide #4) protein is an essential protein to HSV - the virus cannot replicate without it. The in vitro study (test-tube study) announced in June 2003 showed a 100 fold elimination of the virus load.
HSV CP47 (ICP47) permits the virus to evade or hide from the immune system - By elimnating CP47 protein the immune can recognizes the virus and destroys it. This will require a targeted vector - the newer preparation. This essentially is a cure to Herpes simpex Disease.
Where CYGX is with this newer preparation is an open question right now but I have a intuitive feeling, we will be pleasantly surprised.
Best - Rick
Babycake......YEA!
Sanoman.......John, I know the medical community is very upset with the "golden Stahy.aureus" also known as Drug (Vancomyacin - the antibiotic of last resort) Resistant S. A. - I read both the news articles posted here by CD_98 written by Amy Ellis Nutt of the New Jersey Star-Ledger and it is frightening !
More reasons to be looking forward to Dr Chen's article on Spesis in the Biochemistry Journal this month.
CYGX maybe coming just in time to help the human race
with this problem which the medical community feels totally helpless against.
I hope the Biocemistry Journal article is picked up / noticed by assorted journalist so the event gets out to the general public.
There's the "domino effect" with news stories like this, where if just one journalist digs up the story and publishes it, then many more "piggy-back" the same story.
I printed out those Star-Ledger stories and will mail them to CYGX - just so they have background information on the subject. CYGX is more aware of the problem and may have the very solution to save us.
Best to you John - Rick
Hogger.......Jerry, thanks very much for your time and insight with CYGX's CEO and CFO as well as Dr Chen and Harilyn.
Great to have someone right at the "new" scene to not only report to us but to have your the background and experience (5yrs+) with CYGX.
I can see where they are not going to disclose funding other than than in a future public NA and again, they are not worried about it, so there must be a means of funding in place, which we will all know about in time.
The increase in authorized shares sounds logical - they are there if needed and I believe something was mentioned at the end of the summer of a possible company acquistion (a delivery sytem BioTech) but nothing was definite - it's always a method of raising funds and will remain a "pioson pill" device in place. Nothing negative about any of those points. As more and more science comes to light, we will be gald to have these options in place.
Again thank you Jerry for your meeting and sharing with us - you have been a valuable asset to the CYGX board for many years now and we appreciate and enjoy your presence here.
Best - Rick
Tatonkano.......good article going into much more detail than was mentioned by one article you posted before in this area.
Towards the end of the article, it states "certain antibiotics increase the likelyhood of errors by RNA".
I would be very interested in knowing the actual types of antibiotics and to what degree the errors can occur.
It may shed light on the mutations of bacteria taking place so much in the past decades. Although it is not saying that directly. If you or anyone comes across information like that - please post. TIA.
OT Chadman......after reading that article, I think I'll stay home tonight and polish up my "silver bullets".
It is thought provoking !
Isn't great CYGX is something extremely international and very useful.
Best - Rick
OT.........."naked shorting petition"
http://www.investigatethe sec.com
I usually don't do things like this but in this case I make the exception. Please do what you are comfortable with. In anycase something has to be done about this practice.
Take care - Rick
chipperca......thanks for that insight on EDIG - what you are saying makes sense - can you give any, even vague, time frames on this.
Perhaps TA will give some insight?
Sounds like there could a buy opportunity after a sell off which could significant and then with NA's a profit to be made.
TIA - Rick
Tatonkano......once again, thanks for some terrific research - I do remember you putting this together sometime ago. This is quite impt and as you say should give us all confidence in the area of funding questions with substantial proof to back it up which makes sense and also, a rather good endorsement of what CYGX is doing for the future.
This move of doing Herpes clinical studies abroad as well FDA clinical studies domestically will prove interesting and beneficial for CYGX and get the clock moving in the right direction and somewhat sooner in what is normally a slow process.
Best to you and again thanks for the continuous research you give us - we appreciate it alot!
Rick
Chadman & CYGX Longs......I agree with your reactions of the PPS. It should be better but until we get on the Amex or NYSE we will be at the mercy of these swings created by MM's with relation to the value of CYGX. And there will be more.
As Elsiecat has noticed on her Level 2 there are strange things happening to the bid and ask. Before we get too discouraged about that, it can sometimes work against the MM's (its rare but it happens).
Lets keep in mind that a very important paper by Dr Yin Chen of the control of bacteria using "ssDNA Expression Vector" system in Spesis in the Biochemistry Journal. This is the paper that Thalio spoke of presented at the San Diego Genetics conference, where Dr. Chen was invited, which recieved incredible attention from his fellow sciencists. It should come just before Xmas. Now for it's reception ? Can't you just see a MM reading it. Even if they had it, (which they won't) they could not make anything out of it. We will, no doubt, see some buying coming in and thats what the MM's will react to with their usual games.
Think about CYGX's intellectual property value at the present $.50 value - ridiculous! - compare it to other BB corps. making something totally useless and carrying high PPS.
I brought yesterday because of the possibilities in the future (1 to 3 years from now).
Frankly, it's the only way, at present, I can participant in the new era of RNA medicine and a new revolutionary means of delivery to make it work.
Elsiecat also pointed out, that filing a patent, in this case worldwide, protects CYGX's product. This is very impt ! Time periods for patent approval ??? Good question to email to CYGX - CEO for a range of same.
Best to all - Rick
elsiecat......"adjusting DNA " - guess using the word "simply" is bad. CYGX's ssDNA Expression Vector would be traveling into the cell (bacteria) and targeting an area of DNA that would destroy the organism.
Mutation is actually a change in the DNA (evolution).
The new DNA sequence would have to be identified and thats the "adjustment" which would be made - to target the new (mutated) DNA sequence to destroy the resistant bacteria.
So instead of having to develope a complete new or further / newer generation of an existing antibiotic which takes a great deal of time and alot of money (if it canbe done - presently Vancomyacin is presently are last line of defense and some bacteria are getting resistant to that - now which is horrible !)
- hopefully adjustments in the DNA sequence target with CYGX ssDNA vector would insure success on destroying a mutated bacteria.
The impt two things are - there will be a means of death to these killer bacteria and the patented "ssDNA Expression Vector" of CYGX looks like the only means presently of this working.
The article coming in a week or so in Biochemistry Journal on this subject by Dr Yin Chen is going to be very impt. ! Really, this will be the next very large news from CYGX. This is what Thalio was talking about at the San Diego Conference that Dr. Chen was invited too. Apparently, what he stated at that meeting impressed the 100 or so sciencist attending.
If this method of bacterial control is successful, it will start an entirely era in medcine and fortunately just in time.
Best - Rick (10-4 on that DVM)
elsiecat.......if the bacteria mutate, the DNA is simply adjusted. Hopefully attacking the bacteria at a DNA level there will not be any mutation but I believe the jury is out on that one.
CD98.......would please consider emailing the newspaper article on bacterial resistance to both Dr. Yin Chen and CEO Malcolm. I know they are fully aware of these conditions but the content of the artcle may stimulate ideas for the future for presentations to the public of the research work CYGX pursues. Perhaps a short cover letter stating this would be in order.
Hope their internet hook-up is in order.
TIA - Rick
howardjoel......interested in what you thought about those post / links regarding "shorting" stocks in general.
If just a fraction of what was stated is true, we do need investigations and reform into this area.
I have watched certain stocks trade and always wondered what really was going on.
I will be very happy when CYGX events come together and finally the stock trades on a fair market. I know it is a major
propriety for them. It will happen soon (maybe Spring 2004).
Best - Rick
howardjoel......I don't know too much about this but apparently they can short these BB stocks two ways - one up in Canada and two in the Virgin Islands. If they can do this they are playing a dangerous game made for very brave fools and I believe it is illegal but it is difficult to control. Then, there is that element that we don't even know about - someway of shorting, not generally known.
It really doesn't matter other than if it is happening it's making everyone uncomfortable. Wish I could do something about it for everyone.
My position would have been at double what it is now. But I figure I've got enough of a position to live well on if things fall into place.
I do have confidence in the science and as it been said before - to not have forms of future funding just wouldn't make sense.
Don't you think, things uncovered about "Phanuel Pursuits" and its related business groups go far to explain why the group works so quietly and what they are about.
To me it looks like an extremely deep-pockets group of people very involved in "future" type groups in science that will have a positive impact on the world.
Also. I am intrigued about the business plan that will start human clinical trials abroad long before our own country.
There could be a remarkable feed back to quicken progress with the Herpes cream here and worldwide.
If this is the case, it truely is clever by CYGX. And this is only one area which our company is in.
I wish I had some words to lessen the anxiety right now on the site but nothing has changed in the science. There is no bad news I know of. We all have known about the funding problems and I don't think this sell off is about an increase in "shelf stock".
We may well be dealing, as stated before, with end of year selling (tax loss / or profit taking) & "tree-shaking by MM's and a few investors just giving up. Keep in mind that there were a number of investors in CYGX as low as $.03 a share, so $.40 to $.50 looks like a great profit.
We will be alright in time - this is where the guts kick in and we will survive this.
Best to everyone - Rick
Any feedback from others on the means of shorting would be appreciated.
Confession to all......I averaged down some more at this AM.
Remember, I'm in it since 1999.
As Thalio states - Nothing has changed and in fact the science has advanced quite abit just in the last 6 months.
As "Balance Builder" has logically stated considering the nature of the members of the BOD - Science Advisory Board - and now it appears the very nature of the "quiet group" Phanuel Pursuits - they would not be members of a company going under for funding. I think the funding is there. It will be nice when they announce it.
Did I notice a 100 k block pop this early AM with the PPS drop? Anyone following on level 2?
As Hogger suggests, this could shorting (naked or otherwise) or a combination of the gaint tree shake with shorting. Who's knows? I'm in it for the longrun.
I'm long on the science and will add if I can.
Sorry we (you) all have to endue this right now but reward is still there.
Rick
noe43......the NIH report is beyond distrubing.
Looks like it came out in LA Newspaper Sunday Dec 7th.
But the sad thing about this story is, it doesn't surprise me that much - just very upsetting and goes a long way to explain how it all works.
I think we will be seeing much more on this - I hope so.
Rick
Old NA from July 2003 (please note the sentence that Phanuel Pursuits / David Lane have taken an equity position in CYGX.
http://www.cytogenix.com/en_us/Company/Pr_china.html
This link is coming up "not found" (?). It canbe found via "Google" under Phanuel Pursuits (top of page) if you would like to verify the sentence half-way through the post / NA of
"the equity postion taken by Phanuel Pursuits"
Rick.
Thanks Sentinel and John (jtdii) eom
Tatonkano.......After last weeks events regarding Phanuel Pursuits and what the name means (The Face of God),
I definitely remember Tatonkano doing his excellent research back when Phanuel / David Lane were first announced and "T's" reference to the meaning of "Phanuel" as well as insights into David Lane's background.
So in reality, Tatonkano got us all this information the week the licensing was announced.
This brings up a good point. I wish there was some way a continuous listing could be made of the most impt posts as they are given out, so we could use them as a reference to the past information researched.
There's alot of material. Some of it I print out for this reason. Soon, when CYGX is followed by Institutional buyers, they will have to review all of the past history of CYGX
and put it all together for one and all. This will be more than helpful.
Thanks Tatonkano for your continuous research and insight into CYGX. We really appreciate it !
Rick