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Having someone with Garnick's reputation and clout at the ASM meeting or any conference call, etc just gives more credibility to our already suspect BOD. His experience and expertise in the drug approval process is in my opinion second to none. I can't speak for anyone else, but he is one of the main reasons I have heavily invested in this company. I have often explained and promoted his credentials and experience to clients of mine to invest as well. If Robert Garnick can be involved in it, put his reputation on it, then it is good enough for me. For him to continue to show up and still be involved is further confirmation.
Interesting,
Have you looked at the peregrine website, under management team
Robert L. Garnick, Ph.D.
Head of Regulatory Affairs
Dr. Garnick has over 30 years of experience in drug and biologic pharmaceutical development. He was formerly the Senior Vice President of Regulatory, Quality and Compliance at Genentech, Inc. Dr. Garnick spent 24 years at Genentech helping to found the biotechnology industry. While at Genentech Dr. Garnick was responsible for the approval of over 17 drugs, biologics and medical devices. He has extensive experience in analytical methodology, process validation, the regulatory review process both in the US and Europe and in Risk assessments. He has authored numerous scientific papers and has given numerous keynote presentations to the pharmaceutical Industry.
I don't know about you, but I would want my head of regulatory affairs there!!
Wow we think a like, was just going to respond to Dia in regards to how much Garnick likes it. I was going to say I hope he likes it enough to attend the ASM. Consultant or not, his attendance at the ASM would be very telling imho.
Stone,
Couldn't agree more, its amazing how people continue to defend this management team. To see the share price at these levels and no defense of it is ludicrous.
Curious about anyone's thoughts of where we stand if we have to wait until the end of 2016 until the completion of the Lung Cancer Phase III trial:
1) Would that mean the first two look ins were not significant enough to stop the trial? What would the comfort level be at that time knowing the first two look ins didn't accomplish what we are all hoping happens in the first look in?
2) Would 2 more years of waiting allow other big pharmas to further push their current developments in the immunotherapy arena?
Have always figured not a question of if, but when, and assumed the when would be no later than June of 2015, but starting to rethink based upon this company's lack of information and defense of the share price. With dozens of collaborations, 141 sites opened, patients being dosed, partnerships trying to be negotiated, you would think that this share price would be climbing and climbing fast if things were looking good, since nothing is airtight.
Maybe I'm freaking a bit, but dam roller coaster ride kills me.
Science's Top 10 Breakthroughs of 2013:
Every year, the editors of Science huddle together and pick an outstanding scientific achievement as the Breakthrough of the Year. This year’s winner is CANCER IMMUNOTHERAPY: harnessing the immune system to battle tumors. Scientists have thought for decades that such an approach to cancer therapy should be possible, but it has been incredibly difficult to make it work. Now, many oncologists say we have turned a corner, because two different techniques are helping a subset of patients. One involves antibodies that release a brake on T cells, giving them the power to tackle tumors. Another involves genetically modifying an individual’s T cells outside the body so that they are better able to target cancer, and then reinfusing them so they can do just that.
What a complete embarrassment that Bavi( currently in a Phase III no less) and all our supposedly lock tight patents to the hottest cancer topic is valued at less than 100 million.
Cash and Avid are the other half.
Something still not adding up IMHO.
Increased my position to over 8 million with some buys at 0.0085 this morning, but a little concerned about the big orders attempting to sell on level 2 almost 4,000,000 at 0.009 and another million at 0.01.
Would like to see the capsules or vape pens up soon, and of course the announcement of the national marketing wouldn't hurt either. Major concern is will they ever get enough of the product?
Either out of mind or balls of steel, lol
GLTA
None of the references mention specifically Peregrine and links to the references do not mention anything as well. Is there something you can point us to that shows direct correlation to our technology. Much appreciated in advance for most of us non technical medical jargon investors.
Having trouble finding this, but prior to the Sep 12 sabotage, there was a consortium of Biotech companies, I think formed. Does anyone have a link or info about that and where are they today.
It's amazing how much medical science, breakthroughs in PD-1 and PS, immunology, etc has happened just in the past few years.
(Reuters) - Pfizer Inc's Xalkori, which treats lung cancer patients with a specific gene mutation, proved effective in shrinking tumors in those with an even rarer form of the disease, according to data presented at a medical meeting on Saturday.
In the study of 50 non-small cell lung cancer patients with a rearrangement of the ROS1 gene, Xalkori treatment led to significant tumor shrinkage in 36 of them, or 72 percent, and halted tumor growth in an additional 9 patients, researchers reported.
Xalkori, known chemically as crizotinib, was approved to treat patients with a mutation of the ALK gene, along with a companion diagnostic test to identify those with the mutation, which accounts for about 4 percent of non-small cell lung cancers (NSCLC). About 1 to 2 percent of NSCLC patients are believed to be ROS1 positive - the result of a fusion of two genes that are usually separate.
"This is the first definitive study to establish crizotinib's activity in a large group of patients with ROS1-positive lung cancer and confirms that ROS1 is a bona fide therapeutic target in those patients," Dr. Alice Shaw, the study's lead investigator from the Massachusetts General Hospital Cancer Center in Boston, said in a statement.
The average duration of response to the oral drug taken twice daily was 17 months, and half of the patients were still receiving treatment with no evidence of tumor progression, researchers said.
"The remissions induced by crizotinib in ROS1-positive patients are quite prolonged, and (treatment) resistance appears to emerge much later, on average, than what we have seen with other targeted therapies for lung cancer and melanoma," Shaw said.
The study was presented at the European Society for Medical Oncology (ESMO) meeting in Madrid and published in the New England Journal of Medicine.
Advances in diagnostic tools and the understanding of human genetics have enabled doctors to identify patients with the ROS1 mutation.
"This is a great example of success in personalized medicine," said Dr. John Iafrate, medical director of Massachusetts General's Center for Integrated Diagnostics and one of the study's leaders. He called the results "incredibly important for ROS patients."
While ROS1-positive NSCLC patients are rare, Iafrate said, "if you devote the diagnostic laboratory resources to find that 1 to 2 percent of patients, you will make a real difference."
Excellent and thank you
Just read bio's post and I was almost thinking the exact same thing. If we really have the stronghold on PS technology and everyone hs
As to come through us eventually through the patents, then why are we never mentioned and why is the stock price continuing to drop even as the technology and discovery of PS is becoming more known and quoted more often. I mean immunotherapy is the hottest thing in cancer.
Maybe it's me, but doesn't seem like rocket science, you would think the investment pros who research this stuff, would know PS roads lead to PPHM ( supposedly) and this would reflect in the sp.
Something still not adding up?
Ok now I am confused , didn't CP run some numbers estimating an enrollment of 1 patient every 2 months, and based upon that didn't think we would be fully enrolled till June 2015, and yours is figuring 1 every 6 months. Any comments by you or CP appreciated.
Actually reviewing that again, 1 every 6 months looks like it would take a little longer to fully enroll, think you may need to regraph this again
Jbain,
Thanks for the chart, I didn't realize that before this was based on only 1 patient enrolling in each center every 6 months, that is definitely doable, and agree this seems very conservative.
In relation to that can anyone give us a time frame of how many centers were opened, number of patients and time it took to enroll everyone in the Phase II lung cancer trial?
Not my expertise, but didn't this recruitment start in sept 2013, can't imagine with a big pharma involved it would take that long. One of those unsolved mysteries of PPHM. Anyone else?
This year brought even more encouragement. Bristol-Myers Squibb reported this fall that of 1800 melanoma patients treated with ipilimumab, 22% were alive 3 years later. In June, researchers reported that combining ipilimumab and anti–PD-1 led to "deep and rapid tumor regression" in almost a third of melanoma patients. Drugs blocking the PD-1 pathway have not yet been proven to extend life, although survival rates so far have doctors optimistic that they do.
Agreed sparky, if institutions really want these shares only way is to take it up. You hit the nail on the head in regards to anyone still here after Black Monday, which the majority I think are.
We still believe we have the golden goose!
Wasn't this just looking for only 16 patients. I guess they are still recruiting?
Bio,
I like the way you have been hammering the PS links. Interesting to me is what stranglehold do we actually have on PS technology and the patents that go with it? If it is as strong as we think, then the value of this company is astronomical based upon that alone.
How about connecting some dots with the significance of those patents and how they will effect big pharma. Speaking of big pharma and patents and the expiration of patents and the effect of the percentages of revenue lost, jobs lost and strategies of big pharmas now, was reading this article this morning. Maybe it has been posted before, but if not it is a great read in lay mans terms. 90 pages with charts and graphs . A real eye opener that everyone should read.
http://www.bioassociate.com/wp-content/uploads/2012/05/Bioassociate-The-significance-and-apparent-reprecussions-of-the-2009-2015-pharmaceutical-patent-cliff.pdf
Agreed Bio, and I think the core of PPHM shareholders have a different mentality as well. I would think the core holders here, which I believe have a very large position, have been here so long and are so fully entrenched would rather take this down to zero than sell.
For the 50 or so that responded to me, that has averaged around 200k each. So I would agree that is a very low number.
Nice, I hesitated and had to grab 500,000 at .097 still waiting to fill a few more. Said it before, can't imagine if the Capsules come in stock ,and a small PR that this doesn't increase 50%
Well look on the bright side, PPHM close as of 09/19/2013 was 1.38, so we haven't lost a penny. I guess we would be really peeved if the stock market was at all time highs(oops).
Wow away from my computer for a couple hours I guess I missed a lot of fun
Ok, lets go back to the phase II "sabotage". After going through hundreds many thousands of vials, and numerous conversations with the FDA, FBI, team PPHM saves the day.
Fast forward to the start of the Phase III, Stevie gathers every single employee in the company together and says you all know what we have gone through here, it almost killed us, I want to thank each and everyone one of you for your hard work. You also know there may be outside forces here that will stop at nothing to keep us from the ultimate goal of drug approval. It is of ultimate importance for our survival, for your jibs, for the sake of mankind and in memory of Philip Thorpe that we watch every minute detail, check and recheck everything 4 times, listen and watch for anything out of the ordinary that could ruin this trial or cause any doubt.
Here we are today with a message board finding mistake after mistake, and that is only based on web site searches. Let's pray there no mistakes being made where it really counts.
Lets be clear we are here for the science , the science that will someday get the late Mr. Thorpe the nobel piece prize for the discovery of PS ( assuming they have really locked those patents up). I would also state that I am here because Robert Garnick joined this team and most likely it was his trial design and repoir with the FDA that ultimately saved the Phase II trial.
The continued mistakes continues to raise doubt in my mind about the ability of this management team to take us to the promised land, and in a timely fashion.
Lastly are we to believe that there were no mistakes or sloppiness in the Phase ii trial on PPHM's part?
Management, please please please there are lives at stake here, take an honest look at what you are trying to accomplish and if you think it is too much or overwhelming than bring in people who have done it before and are experts in those areas.
In defense, you may be exhausted from working all those extra hours after your regular day jobs handling all the calls you cant get to during the day!!
Forgot to add by email address to this today in case anyone else needs to or wants to add to it bktaxman@gmail.com or PM me.
53 and 10.6 million shares
Cheynew,
Have to agree with you with the majority of bashers are disgruntled longs, with a few exceptions. I think we have all been extremely patient, but would also think that this next 6-12 months would be the max tolerance for patience with this current BOD. AT that point in time if it is the same old, just another upcoming potential list for newbies, and long toothers, then I think most of us will blow our top.
Obviously, the way the BOD is set up, there is practically no way to remove them, maybe a complete breach of fiduciary duty is the only way. I do believe there are ways to add one though and the question is when does the masses or those who have a say cause that to happen. Does even that ability or voice cause the BOD to think or tremble at the thought, lol, who knows their thought process.
For now, I think that most of us have the same thought process of giving this team another 6-9 months, not that we don't think it should be happening now, but after 6-9 months a number of catlysts need to be delivered on, something to move the share price along.
Just so people are aware, I have updated the list of shareholders that have privately emailed me or PM me share counts. I have a list of 49 people totaling about 10.2 million shares. And before anyone goes off saying that this can be used to find out where shares are, will be used to influence you, etc. I say bull----.
It is just a list to know really what we have, and it's a list that if we needed to band together for a voice in what is going on here, then we can stand together if those on the list choose to do so.
I think 20 million would be better, obviously since that is more than 10% of the company, and that would be about 50% of the votes casted last year. Quite frankly I don't know if they will ever be needed, wouldn't know what to do with them, although I do think adding a Board member would be nice. Maybe we can vote for CP.
If anyone else wants to add their name privately email or PM me and I will add your name to the list.
Hope this all a waste of my breath, but I can't imagine going into next year's proxy vote or ASM with the same share price without any substantial changes.
Market and shareholder confidence at an all time high!!
Interesting, maybe Dart and 10 or 20 million from the rest of us combined.
Not sure if Dart would be good or not though.
Like I said, all of this talk is a non issue if things happen lke we are being led will happem.
Procedures for adding or at least nominating can be found in the Nominating Committee Charter: Of course the three BOD's are on that committee and make the final decision if the person presented should be but on for the actual vote by shareholders, lol, can you read between the lines.
EXHIBIT A
Procedures for Stockholders Submitting Nominating Recommendations
1. Security Holders Entitled to Make Submissions. The Nominating Committee of the
Company's Board of Directors will accept for consideration submissions from stockholders of
recommendations for the nomination of directors. Acceptance of a recommendation for
consideration does not imply that the Committee will nominate the recommended candidate.
2. Manner and Address for Submission. All stockholder nominating recommendations must be in
writing, addressed to the Nominating Committee care of the Company's corporate secretary at
the Company's principal headquarters, 14272 Franklin Avenue, Suite 100, Tustin, California
92780. Submissions must be made by mail, courier or personal delivery. E-mailed submissions
will not be considered.
3. Information Concerning the Recommending Stockholders. A nominating recommendation
must be accompanied by the following information concerning each recommending stockholder:
• The name and address, including telephone number, of the recommending stockholder;
• The number and class of the Company's shares owned by the recommending stockholder
and the time period for which such shares have been held;
• If the recommending stockholder is not a stockholder of record, a statement from the
record holder of the shares (usually a broker or bank) verifying the holdings of the
stockholder and a statement from the recommending stockholder of the length of time
that the shares have been held. (Alternatively, the stockholder may furnish a current
Schedule 13D, Schedule 13G, Form 3, Form 4 or Form 5 filed with the Securities and
Exchange Commission reflecting the holdings of the stockholder, together with a
statement of the length of time that the shares have been held); and
• A statement from the stockholder as to whether the stockholder has a good faith intention
to continue to hold the reported shares through the date of the Company's next annual
meeting of stockholders.
Dia,
I'll keep that Florida land in mind, I'm hoping the share price will take me to the promised land. St Augustine or Sanibel ISland my first two choices.
I would be buying as well, but have enough already, diversifying into the Marijuana Field with some GRCU. Could be the next "Microsoft of Hemp", lol
GLTY, thanks for all your efforts
Jake,
Are these the companies to whom PPHM compares us to on their Peer list in the annual proxy materials?
Cheynew,
Have to agree with you with the majority of bashers are disgruntled longs, with a few exceptions. I think we have all been extremely patient, but would also think that this next 6-12 months would be the max tolerance for patience with this current BOD. AT that point in time if it is the same old, just another upcoming potential list for newbies, and long toothers, then I think most of us will blow our top.
Obviously, the way the BOD is set up, there is practically no way to remove them, maybe a complete breach of fiduciary duty is the only way. I do believe there are ways to add one though and the question is when does the masses or those who have a say cause that to happen. Does even that ability or voice cause the BOD to think or tremble at the thought, lol, who knows their thought process.
For now, I think that most of us have the same thought process of giving this team another 6-9 months, not that we don't think it should be happening now, but after 6-9 months a number of catlysts need to be delivered on, something to move the share price along.
Just so people are aware, I have updated the list of shareholders that have privately emailed me or PM me share counts. I have a list of 49 people totaling about 10.2 million shares. And before anyone goes off saying that this can be used to find out where shares are, will be used to influence you, etc. I say bull----.
It is just a list to know really what we have, and it's a list that if we needed to band together for a voice in what is going on here, then we can stand together if those on the list choose to do so.
I think 20 million would be better, obviously since that is more than 10% of the company, and that would be about 50% of the votes casted last year. Quite frankly I don't know if they will ever be needed, wouldn't know what to do with them, although I do think adding a Board member would be nice. Maybe we can vote for CP.
If anyone else wants to add their name privately email or PM me and I will add your name to the list.
Hope this all a waste of my breath, but I can't imagine going into next year's proxy vote or ASM with the same share price without any substantial changes.
Boy you have that right, less than 3 million shares is only about 30,000 dollars, and I was almost a third of that .
Would like to see a minimum of 30,000,000 shares traded.
Also agree, no need to let the hounds out unless we have the stock STOCKED to the hilt
Really,
I'll buy, just give me all the .015, and I will take them, all 800K.
SO just imagine this, where do you think this stock goes when the CBD capsules become available and the next PR comes out about the national campaign. Easy money from here.
Trying to make it an even 6 mil, moohahhah!!, should have bought it at 0.0097, but took too long to sell out of NTEK
Now that's funny, obviously you are high, lol!!
Cheynew,
I had noticed that a while back when researching to if I could find other companies Garnick may have been consulting for. I didn't find any others, but let me give you my take on what I think.
SO PPHM and Garnick talk and agree that Garnick should work for PPHM in some capacity, they agree on some type of compensation, so at that point Garnick has two options.
1) Be paid as an employee or 2) Be paid as a subcontractor/consultant.
I am an accountant and get a lot of phone calls from clients regarding what would be better. I think Garnick chose to get paid as a consultant, sets up a corp. (formed in Nevada in Sept 2008) and therefore can deduct most of his expenses, car, telephone, internet, meals, health, etc. Puts his wife on the books as an employee, so he can write off her expenses as well, since she is an employee of the corp too, well you get the picture.
The alternative is to get paid as an employee, but most of the expenses incurred may be able to be deducted, but are limited to 2% of AGI, but really can't be deducted anyways since the dreaded AMT normally kicks in.
Obviously, PPHM could set up a reimbursement policy to cover him for everything, but he may lose other valuable tax deductions.
Just my thoughts, but I am pretty sure he is locked tight into PPHM alone.
The wife thing was the clincher for me, lol.
Long and strong, but agree completely, it is what it is, but truly I think it would have been better to have kept their mouths shut about website launch date until everything was fully functional and working 100%. At least it gives them time to work out the kinks, but until the caps are up and running, nothing to get crazy about, selling less than what we sold when we started.
If they continue to add products weekly though, it will move along fine. I think not having the link for what is cbd? Would be something they would have written about in the first stages, I mean really isn't that what the company is revolving around.
I'm sure a bunch of you have the same feeling I am feeling. Something blow away coming shortly!!!
Let's get to 0.02 first, will put me above a breakeven with my boatload, but the fun should start there. I like that .10 or even $1 price target with multimillion share count here!!