did the career thing long enough.
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some here think CP's estimate is low by quite a bit....
good grief
cp..
i don't have any conclusions to be wrong about, except that the bod has not yet made any sustainable market cap-improving deals in 20 years despite the supposed astronomical value of their discoveries.
i have said on numerous occasions that i remain hopeful, but i have now become one of 'them' since i have not accepted the bavi platform as a sure thing.....
the discussion point i harp on is simply that blind faith has no place here. i look forward to the day when some of you can say 'i told you so' over success rather than hearing it from the ones who have predicted failure gain.
several of you are ignoring how much PPHM invested in cotara trials, which came through dilution, before they said 'uhhh...nevermind...'.
thanks, north...
pphm is the poster child for all of those except 'insider buying', which there isn't any of here :)
i can't stand it!!!!!!!!!!!!!!!!
just because i point out that the share price remains in quicksand while mileposts/goals/targets/claims have NOT been met in a manner that permanently boosts the market cap, it does NOT mean i have lost faith in the science!
i am NOT happy with management. as of TODAY, they have NEVER CLOSED a big important deal for ANY of their drug development efforts, whether some form or degree of 'sabotage' is an issue or not! what is so hard about accepting that they are failures with a very, very lengthy track record in that regard until they DO?
for cryin' out loud... if SUNRISE shows a 10% OS improvement, i can name 20 posters here who would be certain it was a conspiracy against pphm.
i'm all for letting the facts speak, and i hope 100% improvement in MOS comes to pass, but IMO, too many posters here struggle with the definition of 'facts'.
Geo..that simply isn't the whole truth! they have told us repeatedly that they're trying to partner it to get the funding to proceed with p3, and there aren't any takers! now the science has probably passed them by...
i don't want to see that happen again!
that's not being narrow-minded, and that's a fact!
geo...with all due respect...
cotara was approved for p3. we couldn't fund it cuz we're broke, not because it didn't have efficacy. can't seem to partner it.
what is your idea of a fair price for a bavi partnership?
they had cotara, and the vascular targeting crap they gave to china/epstein outfit... both were supposed to take us to the moon, not the outhouse. if bavi is too late, it can join that club while we have betabodies for the next game-changer.
the rinse and repeat is not only since 2012.
but we'll have updates soon!
note that folks here have had that attitude for almost 20 years now.
i remain hopeful, but, jeez...
don't worry, investors. pphm is worth billions.
sheesh.
the share price confirms that there will be no great news any time soon, and pphm remains dead money.
very disappointing.
oh, cheynew! you're always looking at the glass as half-full! :)
wook..
if it was real sabotage, it worked for sure. the delay could be fatal in light of competing technologies if they can't get if moving fast (not soon)
thanks...couldn't remember when that window starts...
cheynew... no PM capability...
seems they really don't care that they sell so low... is it because they're just buying a little time, after which the current pps will be ancient history, or is it because they have no options?
the BOD says they can't influence the price.
a few million in insider buying might do the trick, but we'll never know.
there's no acceptable excuse for the share price to be where it is.
the BOD sure is making roth, piper, et al look incompetent.
so what negative comment would you have made about pphm? :)
how long till you expect to see the numbers?
regarding Opdivo, and the absence of data...
can you just imagine what AF and DD would be saying about pphm/bavi if data wasn't released after a trial was stopped for efficacy????
calling $1.40 'support' is hysterical.
weren't there other CA's that were dismissed? is somebody mixing them up?
they won't be using CSM, I'd venture to say...
CSM's gonna win.
at 1.40 per share (essentially free), how will my ass be handed to me on this stock at a cost basis of .85? and why are you sure? what is your sure-thing stock of choice? since you're so sure of what you know, how about sharing?
there's been talk of bavi being an upstream checkpoint inhibitor rather than a downstream agent, as those which are red-hot in the BP trials are referred to... it seems critics figured pphm was making that up as bavi's calling card, and they don't like it since it doesn't fit with their agendas.
did you all notice that Shan didn't make that claim today? he went right at the BASF description of its value, head on:
"These data are exciting as the immune responses seen in this translational lung cancer study mirror what we saw in translational data from a liver cancer clinical trial and is perfectly aligned with what has been seen preclinically to date. It was also encouraging to see how well these data further support our ongoing Phase III SUNRISE trial in that the combination of bavituximab and docetaxel induces immune activity," said Joseph Shan, MPH, vice president of clinical and regulatory affairs at Peregrine. "These data are playing a key role in advancing the clinical portion of an Immuno-Oncology Development Program which has been built upon a growing body of favorable data supporting the potential combination of bavituximab and checkpoint inhibitors. Specifically, these data show that activating the immune system in this negative PD-L1 patient population provides a strong rational for combining bavituximab with inhibitors of the PD-1/PD-L1 pathway.
north40000...
if the FDA ever approves bavi in combo therapy, i'm confident several posters here will comment with "LOL! they'll never sell a pill!"
i would like to hear the skeptics' critiques of Moffitt's/PPHM's poster info today, in clinical/scientific terms rather than subjective prose.
i understand that the comments of roth, piper, etc, don't carry any weight here unless they're writing about Roche, gilead, abbvie, etc., but i do not understand why so many folks are hung up on PRs from 5-10 years ago rather than the scientific disclosures over the past year or two regarding pphm's 'platform', which does appear to be stringing decent discoveries of immune system tricks together in ways that may, MAY, fit with other new agents.
is the earth flat?
george, joe, and charles do not seem to be being taken very seriously this morning :)
while we may get full enrollment before Opdivo is easily available, might patients in Sunrise leave for approved Opdivo, screwing up our trial completion?
concerns that bavi is taking too long are legit. rationalizing them away is not productive.
while management has clearly stated they won't give enrollment updates unless they are off schedule, the Opdivo news presents a golden opportunity for giving good news if they are ahead of the scheduled pace.
it also gives them an opportunity to justify why continuing enrollment should not be a problem. that should NOT be cp's job.
a carefully worded PR would certainly be welcome...
ok...now i'm ready to be told that would be stupid.
bio, cp..
you always have decent defenses...and they are appreciated
bio...are you suggesting that biotechs under $5 can't/don't often have massive institutional ownership well in advance of making big moves? that simply is not true.
as for blackrock, that's ONE known outfit. there are countless others who are absent.
i remain invested, i remain dissappointed and increasingly impatient for I/O to change.
I, for one, was not savaging the BOD.
I was criticizing non-stop blind pumping and some posters' refusal to include institutional participation/respect and share price in the equation of what bavi is worth after all this time, particularly in consideration of how close it is to make-or-break.
right now, other that Dart and The Family, the only people showing confidence in it are here.
as silly as 'hopium' was around here, it was easier to deal with that the certainty some posters seem to have over their view that all critics are idiots.
CP...
i am hanging on with my fingernails after what is now about 15 years.
promises, promises, from tustin. one catalyst after another fails to convince big money to come in while we MAY be as little as a few months from going to the moon if you and others are right.
the fact that the share price hasn't moved is a concern.
with as much notoriety as pphm has had over the years, it's no secret that we're close to either heaven or hell. i wish there was a financial indication that we're closer to heaven.
so tustin hired a lot of people for the investigation, and that project ending explains why headcount isn't up now? and just how many people do you think they'll need because they're adding a manufacturing facility that would fit in a ritz carlton lobby?
how many?
there have been tons of jobs posted. none of them said they were short term. how many people does tustin have to hire to work with collaborations on 1 pphm drug, when the collaborators should be bearing the expense if they're not paying pphm???????
you come up with endless excuses and justifications while the share price goes nowhere.
if the market cap explodes, i will be the first to congratulate you for the efforts you've put forth to convince everybody that bavi is destined for greatness, but i'll wait till then to, fair enough?
it is pointless to keep posting job openings.
there have been HUNDREDS of openings over the past 5 years and we have the SAME headcount we've had all this time.
there is a revolving door in tustin. people, other than the BOD and a few others DO NOT STAY.
what might that indicate?
yes, people are burnt out.
75 catalysts were supposed to make the stock go up, but after 75 catalysts, it's down.
some miracle drug we have here.
the gift that keeps on giving to daytraders.
wow.
all that huge March news leaves us down for the month.
what's the RR and PFS for paclitaxel by itself?
had a few daytraders cover...then nothing. pros not interested at these prices since we need to continue significant dilution as of now.