A friend told me that 86% of people will get infected.
And that 15% of those will die.
The current population of China is 1,436,965,010 as of Monday, January 27, 2020

Isn't Chan Chinese?
hint..hint

Okay, valeer15
Google: Wuhan virus cytokine storm

https://www.google.com/search?q=Wuhan+virus+cytokine+storm&rlz=1C1CAFB_enUS681US681&oq=Wuhan+virus+cytokine+storm&aqs=chrome..69i57j69i61.11501j0j8&sourceid=chrome&ie=UTF-8
*************************************
This Is How Long Cold and Flu Germs Can Live on Surfaces Like Doorknobs and Subway Poles

*Breaks out the hand sanitizer.*

“Flu viruses can survive on hard surfaces (like bus poles) and infect another person for 24 to 48 hours,” she says. “Cold viruses don’t survive as long—usually a few hours.

https://www.health.com/condition/cold-flu-sinus/flu-virus-live-on-surfaces

Google: How long can virus live on a surface?

https://search.earthlink.net/search?q=How+long+can+virus+live+on+a+surface%3F&channel=webmail&area=earthlink-ws

The correct N 95 mask/respirator is getting hard to find.
Medical supply stores are out, but flooded with calls.
Some on ebay, check Amazon.

Portable device helps doctors diagnose sepsis faster

"..could be used by ambulances and hospitals to improve the triage process and save lives.

"..tests currently used in hospitals can take up to 72 hours to provide a diagnosis.

https://www.sciencedaily.com/releases/2020/01/200123095857.htm
********************
Uncovering the mechanism behind heart failure, mortality in sepsis

https://www.sciencedaily.com/releases/2017/09/170907093650.htm

****************************
“Skeleton Key” T-Cell Receptor Works across Multiple Cancer Types

“Previously nobody believed this was possible.”

An unconventional T cell, the mucosal-associated invariant T (MAIT) cell, may enable pan-cancer immunotherapies. Unlike conventional T cells, which recognize cancer cells via the human leukocyte antigen system, MAIT cells possess a T-cell receptor (TCR) that works through the evolutionarily conserved monomorphic MHC class I-related protein, or MR1. T cells equipped with the new TCR were shown, in the lab, to kill lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney, and cervical cancer cells, while ignoring healthy cells.

"T cells equipped with the new TCR were shown, in the lab, to kill lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney, and cervical cancer cells, while ignoring healthy cells."

"The most widely used version of this therapy, the CAR T-cell therapy, is personalized to each patient. It targets only a few types of cancers, and it has not been successful for solid tumors, which make up the vast majority of cancers.

https://www.genengnews.com/news/skeleton-key-t-cell-receptor-works-across-multiple-cancer-types/?utm_medium=newsletter&utm_source=GEN+Daily+News+Highlights&utm_content=01&utm_campaign=GEN+Daily+News+Highlights_20200124&oly_enc_id=4013J5551289H0I

JANUARY 17, 2020

Yo, where's Carl da'man?

"One of the first patients treated by CAR-T pioneer Dr. Carl June of the University of Pennsylvania nearly died of cytokine release syndrome; doctors told his wife he “will not see sunrise.”

"Cytokine storms are more likely and severe the more extensive a patient’s cancer and the more CAR-T cells they receive. Overall, 37% to 93% of patients with lymphoma and 77% to 93% of those with leukemia suffer CRS

https://www.statnews.com/2020/01/17/tweaking-how-car-t-therapy-kills-tumors-could-stop-dangerous-side-effect/

Year Revs

2013 $2.4M


2014 4.1


2015 4.8
*
*100%
*
2016 9.5 * *
* *
*59% *
* *
2017 15.1 * * 137% *
* * *
*51% * *
* * *
2018 22.5 * * * 64%
* *
*11% *
* *
2019 24.9 * *
*
*
*
2020 ??.?

Any thing on horizon for 2020?

antithrombotics
endocarditis
refresh
car-t
hemodefend
vetresq
SOC anywhere?
other?

ctso
"After a traumatic brain injury, the body launches an inflammatory reaction that triggers a cascade of immune responses that result in brain swelling.

"After a traumatic brain injury, the most harmful damage is caused by secondary swelling of the brain compressed inside the skull. There is no treatment for this.

"Traumatic brain injuries affect approximately 2.5 million people in in U.S. each year, according to a 2010 Centers for Disease Control report.

https://medicalxpress.com/news/2020-01-dangerous-traumatic-brain-injury.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

Jan. 21, 2020
Roche, Inotrem extend collaboration on blood test for septic shock

https://www.fiercebiotech.com/medtech/roche-inotrem-extend-collaboration-blood-test-for-septic-shock

Couldn't this work in the veterinary industries?
Forward based military hospitals?
what other applications besides skin?
Very interesting company.
Congrats to longs.
I think I missed the train.

Good Sport, would you explain this to me, please?
Thanks in advance.

"Central banks are calling on elected officials to employ taxes, spending and deficits
to combat recessions. "It's high time I think for fiscal policy to take charge" Mario Draghi
said, shortly before stepping down as ECB president.
*******************************************
I'll be sure to forward your reply to Trump.

22 February 2019
Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease(GVHD)

..particularly serious event that can result in significant morbidity and mortality. Proinflammatory cytokines play a critical role in the pathophysiology of intestinal GVHD

cytokines (e.g., IL-6, IL-23, and IL-21), and members of the IL-1 cytokine family, both of which have been shown to induce pathological damage within the GI tract during this disease

Damage to the gastrointestinal mucosa from the conditioning regimen results in the release of damage- and pathogen-associated molecular patterns (DAMPs and PAMPs) (16, 17)...... creating an inflammatory cascade

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00163/full

contact
https://seekingalpha.com/news/3531917-mesoblast-to-complete-u-s-application-for-remestemcel-l-this-month?utm_medium=email&utm_source=seeking_alpha#email_link

Jan. 13 in the journal Nature Biotechnology
Department of Visceral and Transplant Surgery at University Hospital of Zurich.
Switzerland
"a complex perfusion system that delivers blood to the injured livers -- can extend safe outside-the-body storage of livers to up to seven days and offers a wide range of possibilities
Until now, it was only possible to store livers safely outside the body for a few hours.
6 out of 10 poor-quality human livers that were refused for transplantation by all centers in Europe recovered to full function within one week of perfusion on the machine.

https://www.webmd.com/a-to-z-guides/news/20200114/machine-could-expand-pool-of-livers-for-donation?ecd=wnl_day_011420&ctr=wnl-day-011420_RSSFEED4&mb=USjZIq9djpydmPmKyexKGXg0WleHxvIqqEFum6k%40gHE%3d

"We incorporated an integrated dialysis unit for physiologic electrolyte balance and removal of metabolic waste products from the blood.
"In the perfusate, we monitored hepatocellular enzymes (alanine aminotransferase (ALT) and AST), signaling proteins (damage-associated molecular patterns (DAMPs)), uric acid, the proinflammatory cytokine interleukin-6 (IL-6)
"We found that six of the livers, which we numbered 1 to 6, demonstrated a decrease in injury and inflammation markers and DAMPS (ALT, AST, IL-6, IL-10 and uric acid) usually occurring after day 1 or 2 after perfusion, whereas the other four livers (numbered 7 to 10) failed to show any improvement in terms of injury and inflammation markers, as well as DAMPS
https://www.nature.com/articles/s41587-019-0374-x

Cytosorbents Corp (NASDAQ:CTSO) Expected to Announce Quarterly Sales of $6.90 Million(on Thursday, March 5th)

According to Zacks, analysts expect that Cytosorbents will report full year sales of $24.54 million for the current year, with estimates ranging from $23.62 million to $25.74 million.

For the next year(2020), analysts expect that the firm will report sales of $34.95 million(42%^), with estimates ranging from $29.50 million to $44.52 million.

A number of institutional investors have recently modified their holdings of CTSO.

-Cadence Capital Management LLC purchased a new position in Cytosorbents in the third quarter worth approximately $61,000.
-D. E. Shaw & Co. Inc. purchased a new position in Cytosorbents in the second quarter worth approximately $164,000. -Advisor Group Inc. grew its position in Cytosorbents by 15.8% in the second quarter. Advisor Group Inc. now owns 33,170 shares of the medical research company’s stock worth $219,000 after acquiring an additional 4,530 shares during the period.
-Susquehanna International Group LLP grew its position in Cytosorbents by 933.4% in the second quarter. Susquehanna International Group LLP now owns 38,447 shares of the medical research company’s stock worth $254,000 after acquiring an additional 43,060 shares during the period.
-Finally, Charles Schwab Investment Management Inc. grew its position in Cytosorbents by 31.4% in the second quarter. Charles Schwab Investment Management Inc. now owns 81,270 shares of the medical research company’s stock worth $538,000 after acquiring an additional 19,439 shares during the period. Institutional investors own 26.06% of the company’s stock.
https://newsfilter.io/articles/cytosorbents-corp-nasdaqctso-expected-to-announce-quarterly-sales-of-690-million-a217921168066e209161207ef9b3cfea

Misc./
Switzerland
"In all applications that do not focus on cytokine removal but, for example, the removal of bilirubin (liver failure) or myoglobin (rhabdomyoyse), CytoSorb therapy is correctly identified with the CHOP code 99.76.19 “Extracorporeal immunosorbing, other” encoded"

https://cytosorb-therapy.com/en/support/reimbursement-coding-of-cytosorb-therapy/
**********
Sepsis Committee
"FDA-cleared.. results directly from whole blood in 3 to 5 hours..species identification for some of the most common and deadly sepsis-causing pathogens – without having to wait 1 to 5 days or more for blood culture results

https://www.t2biosystems.com/clinicians/sepsis-committee/
******************
MeMed Sepsis™..test for distinguishing between sepsis and non-infective systemic inflammatory response syndrome (SIRS) and determine disease severity. The early diagnosis of sepsis is essential for clinical intervention before the disease rapidly progresses to the more severe stages.

"MeMed BV™ - a pioneering test for distinguishing between bacterial and viral infections that relies on the most accurate detection system.......to support physicians in making better informed antibiotic treatment decisions..
..central lab performance at the point-of-need. Key™ will run the MeMed BV™ test within minutes."

https://www.me-med.com/pipeline
******************
Does anyone else think CTSO's chickens will come home to roost in 2020???

Regarding post # 18494

"..most important driver of market growth will be the launch of four new first-in-class pipeline drugs, BMS-936559, recAP, Traumakine, and CYT107; and three improved therapeutic options, selepressin, thrombomodulin, and cefiderocol."

(1) BMS-936559 Checkpoint inhibitors… for septic shock? Impressive.
Immunotherapy effects on sepsis
https://healthmanagement.org/c/icu/news/immunotherapy-effects-on-sepsis
*****************************
However, like CAR-T, checkpoint inhibitors can cause problems which could require a Cytosorb filter:
https://www.google.com/search?q=checkpoint+inhibitors+managing+immune-mediated+side+effects&rlz=1C1CAFB_enUS681US681&oq=checkpoint+inhibitors+immune&aqs=chrome.5.69i57j0l7.33620j0j8&sourceid=chrome&ie=UTF-8
*****************************


(2) recAP (Recombinant Alkaline Phosphatase) for AKI/Renal Inflammation in Sepsis
https://www.frontiersin.org/articles/10.3389/fphar.2019.00919/full


(3) Traumakine - This is actually for ARDS, which can be caused by sepsis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823184/


(4) CYT107(Interleukin-7)
Researchers Find a New Way to Fight Sepsis
https://www.google.com/search?q=CYT107+sepsis+side+effects&rlz=1C1CAFB_enUS681US681&oq=CYT107+sepsis+side+effects&aqs=chrome..69i57.1945j0j8&sourceid=chrome&ie=UTF-8

(5) selepressin
2019/11/12 "Selepressin Doesn't Improve Outcomes in Septic Shock Patients"
https://www.jwatch.org/na50085/2019/11/12/selepressin-doesnt-improve-outcomes-septic-shock-patients


(6) thrombomodulin
May 20, 2019 "Sepsis Treatment Flops in Phase III Trial"
https://www.medpagetoday.com/meetingcoverage/ats/79929


(7) cefiderocol - primarily for UTIs, "Seizures and Other Central Nervous System (CNS) Adverse Reactions"
Nov 15, 2019 "Report side effects to the FDA at 1-800-FDA-1088"...(huhhh? :( )
Patients with nosocomial pneumonia, bloodstream infections, sepsis, or cUTI were included in the trial.
https://www.shionogi.com/fetroja-cefiderocol-approved-by-the-fda-for-treatment-of-complicated-urinary-tract-infections-cuti-in-adult-patients-with-limited-or-no-alternative-treatment-options/
***************************************

"Furthermore, two new first-in-class medical devices will be launched in the US over the next few years: Toraymyxin and CytoSorb."

-Toraymyxin (a filter) - extracorporeal hemoperfusion cartridge..sepsis or septic shock caused by suspected Gram-negative bacterial infection.
https://www.toraymyxin.toray/en/toraymyxin/

CYTOSORB-XL..." endotoxin removal..head-to-head comparison with the leading endotoxin(gram negative bacteria) adsorber, Toraymyxin™ (Toray, Japan), CytoSorb-XL matched the level of endotoxin reduction..eliminate(s) the need for stand-alone endotoxin specific filters by offering superior performance in the removal of not just endotoxin (but the) simultaneous removal of endotoxin, cytokines, exotoxins, and other inflammatory mediators, but a much broader array of inflammatory mediators.
https://cytosorbents.com/technology/cytosorb-is-easy-to-use-and-implement/

Science Daily
January 6, 2020

Finding a new way to fight late-stage sepsis

"The CDC estimates that 1.7 million adults in the United States develop sepsis each year, and one in three patients who die in a hospital have sepsis."

other sepsis articles, bottom left of link

https://www.sciencedaily.com/releases/2020/01/200106122000.htm

I was reviewing the link in #18493.
It's been my impression that the cytosorb filter is etiology-agnostic, in that it doesn't matter where the infection started/concentrated.
Such doesn't appear to be the case with the drugs listed in the link.

Wouldn't that be a big advantage for us?

3rd paragraph, last sentence

01 Sep 2017
Sepsis & septic shock market to be worth $5.9 billion by 2026

(In the mean time sepsis is costing us $23.7B/yr.,post#18490)

"Sepsis has a 78% share of annual drug revenues with approximately $2.2 billion in 2016 sales, and septic shock a 22% share with sales of $0.6 billion across the 7MM."

"..most important driver of market growth will be the launch of four new first-in-class pipeline drugs, BMS-936559, recAP, Traumakine, and CYT107; and three improved therapeutic options, selepressin, thrombomodulin, and cefiderocol."

"Furthermore, two new first-in-class medical devices will be launched in the US over the next few years: Toraymyxin and CytoSorb."

https://www.globaldata.com/sepsis-septic-shock-market-worth-5-9-billion-2026/
**********************
More respectable print (in BOLD LETTERS)

"The US market will witness the launch of two medical devices in the future, namely Toraymyxin and CytoSorb."

https://www.pharmaceutical-technology.com/research-reports/researchreportreport-sepsis-and-septic-shock-treatment-to-be-a-59bn-market-by-2026-5921758/
***********************************
Nov 04, 2019
Sepsis Treatment Market 2019: Emerging Technologies, Sales Revenue, Key Players Analysis, Development Status, Opportunity Assessment and Industry Expansion Strategies 2025

http://www.kake.com/story/41266671/sepsis-treatment-market-2019-emerging-technologies-sales-revenue-key-players-analysis-development-status-opportunity-assessment-and-industry

"7.1.3 Germany"???

same thing from Marketwatch

https://www.marketwatch.com/press-release/sepsis-treatment-market-2020-overview-cost-structure-analysis-growth-opportunities-and-forecast-to-2025-2019-12-04

What fluids do you give for sepsis?
Normal saline is one commonly given fluid.

"Antibiotic Recommendations for Sepsis and Septic Shock"

Depending on ETIOLOGY, welcome to Big Pharmo

Which antibiotics treat sepsis?
“This includes.."

ceftriaxone
azithromycin
ciprofloxacin
vancomycin
piperacillin-tazobactam
Tobramycin
Aztreonam
Cefepime
Levofloxacin
Ceftriaxone
Metronidazole
Clindamycin
Oxacillin/nafcillin
Gentamicin
Ertapenem

https://www.nebraskamed.com/sites/default/files/documents/for-providers/asp/sepsis-antibiotics-2019.pdf

First National Forum on Sepsis Sponsored by The Rory Staunton Foundation Announces Speakers & Registration Information
July 29, 2014

Speakers to date include (note next to last, University of Jena, Konrad Reinhart):

U.S. Senator Charles E. Schumer (D-NY)

Nirav R.Shah, M.D.,M.P.H.- – Vice President & Chief Operating Officer for Clinical Operations at Kaiser Permanente, Southern California. Former New York State Health Commissioner and co-author of Rory’s Regulations.

Thomas R. Frieden, M.D.,M.P.H. – Director, The Centers for Disease Control and Prevention (CDC).

Kevin J. Tracey, M.D. – D President and Chief Executive Officer of the Feinstein Institute for Medical Research.

Martin Doerfler, M.D. – Associate Chief Medical Office and Senior Vice President of Clinical Strategy and Development – North Shore-LIJ Health System.

Konrad Reinhart, M.D. – Director of Clinical Anesthesiology and Intensive Care Medicine a the University Hospital of the Fredrick-Schiller University Jena, Chairman, Global Sepsis Alliance, World Sepsis Day

Patrick Conway, M.D.– Deputy Administrator for Innovation & Quality, CMS Chief Medical Officer

https://rorystauntonfoundationforsepsis.org/category/press-releases/page/2/
*******************
misc.

"The Rory Staunton Foundation (www.rorystaunton.com) and Global Sepsis Alliance (www.globalsepsisalliance.org) today announced that they will unite to fight against sepsis

The Rory Staunton Foundation’s achievements under the direction of Orlaith and Ciaran Staunton came to the attention of the Global Sepsis Alliance (GSA), under the leadership of - Dr. Konrad Reinhart - and Dr. Ron Daniels, as a shining example of strategies to engage governments. The GSA has achieved world successes in engaging professional societies, healthcare providers and policy makers (www.world-sepsis-day.org).

National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2013

"Septicemia was the most expensive condition treated, accounting for $23.7 billion, or 6.2 percent of the aggregate costs for all hospitalizations.

"Number of hospital stays(2013), thousands...1,297"

napkin + pencil

https://www.hcup-us.ahrq.gov/reports/statbriefs/sb204-Most-Expensive-Hospital-Conditions.jsp

"Sepsis kills more than 258,000 Americans each year." - inexcusable

The Centers for Medicare & Medicaid Services (CMS)...will adjust hospital paymentsby quality of sepsis treatment....will require hospitals to publicly report compliance with National Quality Forum’s “Sepsis Management Bundle.” This includes a handful of proven practices such as heavy-duty antibiotics and intravenous fluids.

PA to Adopt Rory’s Regulations – Mandatory Sepsis Protocols to Be Enacted Statewide
Illinois Governor Signs Mandatory Sepsis Protocols into Law

**********************************
Ciaran Staunton -
Orlaith Staunton - 917­ 523 ­8467
New York Assembly by Assemblywoman Catherine Nolan of Queens -

Contacts
The Rory Staunton Foundation
Deirdre Hickey, 212.244.6294/718-482-0088

I could find no mention Cytosorb filter, though we're listed as a sponsor (at bottom of pages)

The Rory Staunton Foundation for Sepsis Prevention

https://rorystauntonfoundationforsepsis.org/

135 West 50th Street, Eurotech Suite, 5th Floor
New York, NY 10020

Email: info@rorystauntonfoundation.org
PHONE: 212.244.6294

******************************
December 6, 2017
Governor Cuomo Signs Law Introducing Sepsis Education Curriculum to all New York State Schools

"This Bill was introduced in the New York Assembly by Assemblywoman Catherine Nolan of Queens."

“Once again, New York State has led the way in providing pragmatic solutions for defeating sepsis, a condition that shatters families like our own on a daily basis.”

The Rory Staunton Foundation was established by Ciaran and Orlaith Staunton following the preventable death of their 12-year-old son, Rory, from sepsis in 2012. The Foundation is dedicated to improving the recognition and treatment of sepsis through public education and improved hospital protocols.

"Sepsis, a potentially fatal condition stemming from infection, claims more lives in the United States than AIDS, breast and prostate cancers, and stroke combined and costs the U.S. healthcare system $24 billion per year, according the American Medical Association.

Napkin + pencil

https://rorystauntonfoundationforsepsis.org/8790/governor-cuomo-signs-law-introducing-sepsis-education-curriculum-new-york-state-schools/

FDA releases list of devices exempted from 510(k) clearance

The FDA has released a list of Class I and Class II medical devices that will be exempted from the 510(k) premarket notification process. The list includes hematology and pathology devices, clinical chemistry test systems, clinical laboratory instruments, radiology devices and ophthalmic devices.

https://www.medicaldesignandoutsourcing.com/fda-publishes-final-list-of-510k-exempt-devices/

techxen,
1.The trial is being paid for by the Germans, right?
2.They gave their ok to continue with it after interim results, correct?

It sounds like that dog hunts.

10:50

What about the dogs? Available in US 2017

https://cytosorbents.com/products/VetResQ/

https://cytosorbents.com/cytosorbents-launches-vetresq-for-u-s-veterinary-market/

US proposes new rules to increase organ transplants

http://enews.earthlink.net/article/us?guid=20191217/1931eeca-488f-45d2-b017-974b0ea2ce1e


ctso
"..to perfuse, cleanse, recondition and preserve harvested kidneys and livers — including those that are usually discarded.

https://www.medicaldesignandoutsourcing.com/could-this-system-make-more-kidneys-livers-usable-for-transplant/

from here
https://www.google.com/search?sxsrf=ACYBGNQdWgzd0o8YytYA16Od5tTJRryPeg%3A1576629764823&source=hp&ei=BHb5Xe7XLpHm_Qbwv4KYAQ&q=Cytosorbents+organ+transplants&oq=Cytosorbents+organ+transplants&gs_l=psy-ab.3..33i299.3641.33001..39770...1.0..0.259.3320.23j7j2......0....1..gws-wiz.......0j0i131j35i39j0i67j0i10j0i22i30j33i160j33i10.vU5taInORtA&ved=0ahUKEwju6cjI-73mAhURc98KHfCfABMQ4dUDCAg&uact=5

Maybe it'll appear here later
Latest Show Clips
The latest from FOX Business Network
https://video.foxbusiness.com/playlist/on-air-latest-show-clips/

Here's yahoo. Surely he talked about more than politics
I would like a link.

"Chan was just on Fox Business News. This was posted on FB:
Dr. Phillip Chan, Chief Executive Officer of CytoSorbents Corporation (NASDAQ: CTSO) was recently invited to appear on Fox Business News’ FBN:AM program hosted by Cheryl Casone and Lauren Simonetti. During the interview, Dr. Chan discussed how its European Union approved CytoSorb blood filter is being used to control deadly inflammation to help save the lives of critically-ill patients around the world, generating nearly $22M in sales of this “Brita filter for your blood” over the past 12 months, and how the company is expecting strong growth in 2020. They also discussed results of a major study released at the American Heart Association meeting concluding that for those with stable angina, optimal medical management was as safe as intervention with stents or coronary bypass graft surgery for up to 5 years in terms of cardiac related outcomes, potentially saving more than $500 million in costs to the healthcare system each year. And finally they touched on “Medicare for All” where Dr. Chan expressed concern that the proposed budget of $20 trillion over 10 years was massive...”the equivalent to doubling our federal debt, or the magnitude of our entire gross domestic product”...the sum of all goods and services produced in the US each year, and that taxing companies and individuals for it could cripple the economy. He believes that we have a social responsibility to make sure that all Americans have healthcare coverage but also warned not to be too hasty. Dr. Chan stated, “This is not about a presidential legacy. It is about getting it right” and stated “If the Affordable Care Act has taught us anything...the healthcare system is so complex that even with smart people designing a new system with good intentions, we cannot predict how it will work.” Dr. Chan is an advocate of modeling this with artificial intelligence and irrespective of what healthcare system is ultimately chosen, that it be rolled out regionally and beta-tested before upending a healthcare system that today, although far from perfect, works for the majority of Americans, stating that “once you get rid of private insurance, there is no going back.”

Did Chan mention this on television??

'Obamacare' tax repeal added to $1.4T wrap-up spending bill

"A tax on medical devices and health insurance plans would also be repealed permanently.

I don't know which is better. The impeachment joke or the shorts' joke.

Hey hemo, berth,andy - a "Masterclass"!

International Fluid Academy is actually offering this class at their website - a little over halfway down.

https://www.fluidacademy.org/

********
https://www.fluidacademy.org/blog-ifad-2018/item/satellite-masterclass-symposium-on-cytokine-removal-copy.html
********
Petition to retire the surviving sepsis campaign guidelines
We need a paradigm shift in the way we develop guidance and treat our sepsis patients

"The 2018 SSC update is actually worse than prior guidelines"

https://www.fluidacademy.org/blog-ifad-mini/item/petition-to-retire-the-surviving-sepsis-campaign-guidelines.html
**************
They have a discussion group link (at the bottom right,of fluidacademy.org,"join Discussion group") that goes to linkedin...can talk to users of the filter?

https://www.linkedin.com/groups/4083056/

Twitter link too

and Facebook, a blog, newsletter....

Let know what you find out.

DECEMBER 6, 2019

Swiss approve insurance cover for Novartis, Gilead cell therapies

"The Swiss government approved on Friday health insurance coverage for CAR-T cell therapies from Novartis and Gilead Sciences, which can cost hundreds of thousands of dollars per patient.

https://www.reuters.com/article/us-swiss-medicine/swiss-approve-insurance-cover-for-novartis-gilead-cell-therapies-idUSKBN1YA1GY?feedType=RSS&feedName=healthNews

What % of CAR-T patients have the "side effects"?
costing the hospital how much $ per patient (aver.)?
(more filters, please)
**********
Try, Try Again: Can a 2nd Dose of CAR T Cells Succeed When the First Fails?

"..glimmers of success. One month after the second infusion, the cancers of eight patients had disappeared; in eight more, the cancers had shrunk.
(more filters, please)

https://www.fredhutch.org/en/news/center-news/2019/12/repeat-dose-car-t-cells.html
*****************
Too bad we're not approved in China YET. Is Chen/Chan from China? He have any connections there?

"CAR-T works by supercharging T-cells..process of engineering an individual’s cells in a laboratory and then replicating them has also meant that some patients with more aggressive cancers can die waiting for treatment.

"Instead of the two to three weeks taken by current treatments from American and European drug makers, the Shanghai-based company ( Gracell) is churning out cancer-killing immune cells overnight.
(more filters, please)

"..plans to price its CAR-T treatment for about 500,000 yuan ($71,000), well below the $475,000 price tag for Novartis’ Kymriah, the Swiss company’s CAR-T therapy used to treat the type of blood cancer that Zhang had. A similar treatment from Gilead, based in Foster City, California, costs $373,000.

"China likely to approve CAR-T for widespread use as early as next year.
(lots and lots of more filters, please)

https://www.bloomberg.com/news/features/2019-12-10/cancer-treatment-china-mulls-looser-experimental-therapy-rules?utm_source=newsletter&utm_medium=email&utm_campaign=newsletter_axiosvitals&stream=top#_ga=2.44199203.666170465.1576088682-198729073.1576088682

Deloitte's 2019 fast 500
68% Of Deloitte's 2019 Tech Fast 500 Are From Software

#276

https://www2.deloitte.com/content/dam/Deloitte/us/Documents/technology-media-telecommunications/us-tmt-fast-500-2019-winners-list.pdf

adjunct therapy?

"What we can do is give physicians a fighting chance to regulate the inflammatory response of TBI, rather than trying to treat it after it occurs."

https://medicalxpress.com/news/2019-12-brain-straight-vein-iv-treatment.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

Aliberto,

If "Intraoperative cytokine hemoadsorption (HA) mitigates the inflammatory response.",

and " (miRNAs) are emerging as a marker of myocardial injury.",

then how.. "MiRNA-133a plasma levels were increased postoperatively in both groups but were much higher in the HA group"

and "Intraoperative cytokine HA in cardiovascular operations increased the plasma levels of miRNA-133a, suggesting higher myocardial injury.

I don't understand. I'm ignorant/reading this wrong.
Seems like the 133a marker would decrease indicating less damage.
So the filter cannot protect the organ it's supposed to protect?

Is this Chan's (Chen?) fault?

related somewhat -

Septic Shock Secondary to Pyelonephritis (kidney)

Discussion:

This case highlights not only T2Bacteria’s ability of rapid identification but also the capability to detect the causative organism in the presence of antibiotics. The patient, in this case, received a dose of ceftriaxone and azithromycin before the blood cultures and T2Bacteria were drawn. Bloodstream infection was missed by blood culture but was identified with rapid detection provided by the T2Bacteria Panel. The use of T2Bacteria, in this case, allowed an early confirmation of effective antibiotic therapy.

Presentation:

A 55-year-old male presented to the hospital from an outside facility with sepsis secondary to pyelonephritis. Before transfer, the patient received one dose of ceftriaxone and azithromycin. He was subsequently admitted to ICU with septic shock and acute renal failure, which required initiation of continuous renal replacement therapy. Blood cultures, urine cultures, and T2Bacteria Panel were obtained.

OT
Need a tax deduction?
https://tunnel2towers.org/gold-star/?cid=1621816078&agid=60642303494&mt=b&dev=c&gclid=Cj0KCQiAoIPvBRDgARIsAHsCw095oF0o3CCzAzFkMBH6HJpnChUjs1V6dUFd_wdl9Vrrj9AldTyn2xMaArQTEALw_wcB

I emailed Bianca, the doctor, the literature.cytosorb link, with a note.

ctso's filter would cost less and work faster, and be in use years b4 this research is finished

Interesting though.....


Nanoparticles and Cancer Drug Combined to Target Inflammatory Neutrophils
November 7, 2019

https://www.genengnews.com/news/nanoparticles-and-cancer-drug-combined-to-target-inflammatory-neutrophils/?utm_medium=newsletter&utm_source=GEN+Daily+News+Highlights&utm_content=01&utm_campaign=GEN+Daily+News+Highlights_20191107&oly_enc_id=3781H8231356A1W