All the people known by our miniscule group of people do not equal even just one fund having decided to dump COR shares because it no longer meets their criteria.

Maybe, but if a large holder decided to sell, wouldn't they be evaluating their decision in real time, thus making a calculated decision (as opposed to an automated, mindless pull of the trigger). If people/funds got burned, they would have been gone a while ago(unless they believe and hope, like us). The criteria would have changed at 3.3 ps, or 2.5 per share. Now would not seem like the time to pull the trigger. And investors, particularly large ones, would/should be wise to the renewed hope expressed in the CC. IMO

Curtis

1) I posted recently about our living in an Ampa-centric world--that does not reflect the view of the bigger investment community. We hang on every word said on a CC which was given 48 hrs notice, and no PR stating the important components. Most people in the biotech world heard nothing of this, and few would give a damn if they had, because they have filed Cortex in their 'dead end' file and it will take something much more public to have them recategorize this story.

Neuro, I find that somewhat hard to believe. Making money is at the forefront of most investors' minds. The feeling of getting in on the ground floor is also satisfying. Many investors, brokers, and various other groups or individuals, prowl the various resources available to potentially find the next best thing. It's exciting. To some it's a rush, and others, just business. Hell, even Trump gave some hoe, I mean good-looking party chic, a second chance. Sure some have been soured, but then again, in this day and age, memories are getting shorter (so let us expedite this CX 717 to market). Really though, people don't care, that is, if they can make up for it again, say with a low price entry and a double, triple or even larger size gain, I'll bet those old, sour memories can even be erased. Not that they should be erased, because it is all part of the story. It all should be embraced, preferably, with a happy ending:=)
Kind of makes me think of ADHD drugs, where we have gotten to the point that we'd rather our children "tame" their personalities (emotionlessly with ssri's and such), rather then embrace and learn from the "ups" and "downs" of ones trait given, and environmentally evolved, neurological imbalances. Sorry, I went on a rant. I'm sure some kids really do need them ADHD drugs.
When it comes to tremendous potential, both financially and neurologically, I think people do give a damn. But you are probably right, people want to see the news. That way, they can chase a running stock and satiate their own adrenaline induced imbalances. I'm guilty. I sold part of Cor at 5.75, but bought much more back at 5. I got suckered, and felt victimized, but hey, my own damn fault. Unfortunately, I've been digging my nails in ever since, and I got to tell you, I really am perplexed by the lack of speculating by the market on a speculative investment with wonderful news. Stoll knows people, R&R know people, you know people, and so on and so forth......This is what concerns me a little about my investment.

Curtis

Does anyone have a good theory on why Cortex didn't release a PR following the CC? As someone mentioned earlier, it could have helped the share price. While I am not overly worried about current price fluctuations (the fda decision should create a lasting, directional move), I am concerned that there has not been more exposure regarding the "positive" news.

The optimistic side of me says they wanted to fly under the radar of the fda-by not appear too cocky about the findings(knowing where the fate of CX 717 ultimately lies).

The pessimistic side seems to have many more questions:
Why aren't the institutions/funds more actively buying? They were either at the meeting (R&R), or privy to the info. What about the investment arms of BP's? Wouldn't they see a good opp. here? Large investors? ect.

Regarding this lack of buyer interest, what are the reasons?
Are their still safety/histo questions (although some on this board don't seem to think so)? Do we still need to find out why cellular change (supposedly)only happens post death, or based on that determination, is it a non-issue?

I guess there are more questions to be answered in this "story" (aka "mystery")of a stock. What a crazy "game" (aka "puzzle) investing is! Particularly in biotechland.

Good day

Curtis

Curtis

We certainly received a handful of info today, much more than I was anticipating. It does "sound" good, and I want to believe the artifact theory. But we are missing one crucial element to this "good" news, and that, obviously, is a positive market reaction (by way of price appreciation). Hopefully this will come, but what concerns me is that the usually astute market players did not react to the seemingly fantastic news. What about after hours?

I am excited and relieved, but I gotta tell ya', I'm not convinced we are out of the woods with the histo findings yet. Apparently I'm not the only one. The SP, to me, is proof that the saga continues.

fearfrost-thanks for the cc news
gfp-thanks for playing devil's advocate
blade-try not to dwell on the in-licensing so much.

Curtis

I see two ampakines listed in the following link
http://www.organon.com/innovations/pipeline/index.asp

Speaking of ampakines, gfp, do you think that Organon has information gathered on their Org-24448 study? If it is highly likely, that could be a big negative for Cortex/ampakine. Because they are out of favor with the asenapine news, any positive would help. Hell, any positive would help anyway. It would make sense, anyway, for Akzo to "dress-up" the IPO/sale of Organon.

On the other hand, for obvious reasons, no news would be described as "bad news." It probably is not material to Organon (ampakine drug findings), so they would not be required to release info.

Just speculating. Your thoughts?
Curtis

I have been waiting for BLSI for 8 years. It had some big jumps, but would always fall back down. In the last few years, it would spike and bottom quickly, with very little time to react. This move today, however, was fairly tame. For that reason, and the fact that I relinquished the remains of my position in the past month, it has a chance of steady appreciation, seemingly to inflict pain on me.
My father has MS, so naturally I invested in neuro biotech, and hoped they could develop something promising. It was like a decade of 9th grade History lectures waiting for them to follow through with their lead products/candidates. They rarely seemed obligated to release much info to the shareholders, almost as if they were hardly working. Maybe they were at a weekday neuroscience picnic and decided they had to release "something" before their stock plummeted to the pennies and they would have to declare another reverse split. That's when they ran into an officer of the Canadian company, and came up with this "masterpiece."

Honestly, I hope they ultimately can regenerate severed/dead/unresponsive nerves. It will just be too bad I'm not on board. But Cor on the other hand.........

Chiming in on your discussion... I feel there are glaring signs of why one would purchase more Cortex at this time (but not on margin, never again, and not that you could at this price anyway).

1)The price is ridiculously cheap, and the market cap is discounting their compounds' potential value.

2)Play it as a value stock(ha-ha), buy it low (here), and sell it with a nice double (quite possible)

3)It seems Cortex is at it's closest point to developing something, albeit with a caveat at this juncture. AD could be huge, considering the aging baby boomers and their dependence on pills.

4)One could dramatically improve their cost basis at this level, with many having bought higher. Percentage increases would also be huge with any good news.

5)Yes, the attachment (falling in love), I'm actually surprised that someone like yourself, Gfp, who did not get attached to individual stocks, found himself here and did not leave (actually, I guess you did). It's particulary interesting that you are here, and do not own Cortex. But then, we are all fascinated by different things.

Personally, I think your contribution to this board is fantastic. I'd hate to see you go, and I'm sure most agree (that is, if they are not too bitter about their botched investment, I mean gamble, on a hit or miss get rich dream).

I agree with daviddal, the risk is part of the ride. What if Cortex was the next Cephalon, is it far-fetched? I think not. (By the way, wasn't Ceph's blockbuster drug in-licensed?)

For my two young childrens' sake, I sure hope Cortex matures. My wife knows what I'm doing, and she is not happy. Yes we reap what we sow, but we do it for love. Cortex could prove to be worth the emotional strain that goes into parting with our money, and not knowing if we will get it back.

I have not, and will not gamble all their ugma money away in Cortex (at least not now, maybe if the share price cuts in half again).

If it pans out my grand strategy will be to reduce their risk by dealing with more stable companies or investment vehicles. A small percentage will continue to be used for spec. But as they get closer to adulthood, the spec percentage will be minimal. Let's just hope Cortex rules

If if doesn't pan out (quite possible), it will be like BLSI for me. I thought they were going to cure paralysis, but the stock remains paralyzed. I may not forget it, but the pain goes away (even though the disgust will always stay).

To better days

Curtis

I'd like to say we are "truckin'," but "sputtering" is more the reality.
At the expense of being cliche, I'd like to wish the longs a pleasant new year, and a new beginning for cortex pps.

Curtis

I know one approach to investing is "buy when nobody else wants it", but this is getting ridiculous! Then again, is this "investing" or is it financial suicide?

No need to reply

Curtis

Open question:
Assuming CX-717 is dead for ADHD (and hoping it is still alive for AD), what are some realistic possibilities going forward?

What I'm getting at is:
Could they determine what caused the histo finding, modify the chemical make-up, and "re-start" the program with the new version? Is this reasonable? Plausible? Pointless? Expensive?
After all, wasn't CX-717 "tweaked" from CX-701?

Any response would be appreciated?

Curtis

gfp-according to my calculations (assuming where you are, the double cheeseburger is a dollar menu item), every three double cheeseburgers equal 2 shares of Cortex at a (hopefully) bargain price (excluding commissions of course). I know you think it's risky, but as you pointed out, so are too many fast food burgers. I guess you're spreading your risks out.

BTW-regarding current adhd, anti-depressant, etc. drugs on the market, are they all cns stimulants? And if so, what are their affects at heroic doses (cellular changes?). Also, would someone "feel" a change in their thought processes or behaviors with cx717 (hypothetically or otherwise), like cns stimulants ? I know your discussions are mostly technical, but it is hard for me to get a "visual" of the operation of the drug.

Thanks

To all

First time poster, long time lurker(since cor went from 3's to 2's, and Gfp bid farewell ((originally)) to yahoo message board). I almost pulled the trigger myself, not knowing much about the company, and not having been exposed to the cor posters.

Then, out of nowhere, the stock took off. Obviously, I became more and more interested, and got more and more involved in the posts.

Fast forward to the present. I now have 5 x's the original position, and it has been a wildly emotional ride. Sure I am overweighted in this company, and tempted at times to dump everything I have into it, but fortunately, more rational decision making has prevailed. We shouldn't blame the company, their CC's, their PR's etc. for our losses . We are emotional because we believe in their potential. We made the choice to invest, or over-invest etc.

I, like many, have lost quite a bit of optimism. But, be it out of stubbornness, stupidity, or hope (partially due to the intelligent discussions I read on this board), I am going to stick through doom and gloom.

A final note,
Basically since I've been following this stock, It has moved contrary to the psychological consensus on this board. The mood was stagnant before adhd, excited anticipation before darpa, optimism during hold, relief after hold lifted, and misery after fda letter. The moral is, expect the unexpected.

Good luck